Yuraldo, Billhaqqi (2023) Analisis Morfologi dan Performa Wound Healing Komposit Nanofiber PAN/Cu2O Quantum Dots dengan Metode Spray Coating. Other thesis, Institut Teknologi Sepuluh Nopember.
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Abstract
Luka kronis adalah luka yang memiliki waktu proses penyembuhannya lama dan tidak dapat diprediksi serta menyebabkan komplikasi lebih lanjut seperti infeksi dan gangguan penyembuhan. Faktor resiko terjadinya luka kronis adalah infeksi oleh bakteri. Pengobatan berbasis antibiotik belum mampu mengatasi Luka kronis secara akurat. Hal tersebut disebabkan oleh adanya fenomena antimicrobial resistance (AMR). Untuk mengatasi hal tersebut, komposit nanofiber PAN/Cu2O QDs menjadi salah satu solusi yang efektif karena dapat memproduksi reactive oxygen species (ROS) dengan konsetrasi rendah yang dapat menstimulasi angiogenesis dan meransang migrasi sel kulit dan polifrasi polifirasi sel. Komposit nanofiber PAN/Cu2O QDs memiliki sifat antibakteri pada bakteri gram positif dan negatif pada nanopartikel, dan memiliki kemiripan dengan lingkungan ECM. Oleh karena itu penelitian ini bertujuan untuk memahami pengaruh pelarut koloid Cu2O dan volume koloid Cu2O terhadap morfologi dan performa wound healing. Dalam penelitian ini, Cu2O quantum dots disintesis menggunakan metode wet chemical, nanofiber PAN disintesis menggunakan metode electrospinning, dan komposit nanofiber PAN/Cu2O QDs disintesis menggunakan metode spray coating. Sampel diuji dengan pengujian TEM, XRD, SEM-EDX, AFM, Uv-Vis, Hidrofobisitas, Zeta Potensial dan Wound Healing. Hasil sintesis Cu2O didapatkan ukuran sebesar 9,61 ± 1,727 nm. Hasil pengujian SEM didapatkan ukuran diameter nanofiber sebesar 420,51 – 454,45 nm. Nilai Average roughness dan Root Mean Square Roughness berturut turut sebesar 87,6 nm dan 117 nm serta 142 nm dan 177 nm. Nanofiber PAN/Cu2O memiliki sifat hidrofilik dengan kontak sudut air berkisar 43,622 – 48,489 derajat. Sampel dengan Cu2O terlarut dalam 1:1 Octadecene dan Heksana mengandung muatan positif sebesar 10,3 mV dan sampel dengan Cu2O terlarut dalam Octadecene mengandung muatan negatif sebesar -21,7 mV. Dari penelitian didapatkan bahwa morfologi mempengaruhi performa wound healing dimana ukuran nanofiber yang kecil, kekerasan permukaan yang tinggi, sifat hidrofilik serta muatan permukaan negatif mampu meningkatkan kemampuan wound healing.
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Chronic wounds are wounds that have a long and unpredictable healing process and cause further complications such as infection and impaired healing. The risk factor for chronic wounds is infection by bacteria. Antibiotic-based treatment has not been able to treat chronic wounds accurately. This is caused by the phenomenon of antimicrobial resistance (AMR). To overcome this, the PAN/Cu2O QDs nanofiber composite is an effective solution because it can produce low concentrations of reactive oxygen species (ROS) which can stimulate angiogenesis and stimulate skin cell migration and cell proliferation. The PAN/Cu2O QDs nanofiber composite has antibacterial properties on gram-positive and negative bacteria on nanoparticles, and has similarities with the ECM environment. Therefore this study aims to understand the effect of Cu2O colloid solvent and Cu2O colloid volume on the morphology and performance of wound healing. In this study, Cu2O quantum dots were synthesized using the wet chemical method, PAN nanofibers were synthesized using the electrospinning method, and PAN/Cu2O QDs composite nanofibers were synthesized using the spray coating method. The samples were tested by TEM, XRD, SEM-EDX, AFM, Uv-Vis, Hydrophobicity, Zeta Potential and Wound Healing tests. The results of the synthesis of Cu2O obtained a size of 9.61 ± 1.727 nm. SEM test results obtained nanofiber diameter size of 420.51 – 454.45 nm. Average roughness and Root Mean Square Roughness values were 87.6 nm and 117 nm and 142 nm and 177 nm respectively. PAN/Cu2O nanofiber has hydrophilic properties with a contact angle of water ranging from 43.622 – 48.489 degrees. Samples with Cu2O dissolved in 1:1 Octadecene and Hexane contain a positive charge of 10.3 mV and samples with Cu2O dissolved in Octadecene contain a negative charge of -21.7 mV. From the research it was found that morphology affects the performance of wound healing where the small nanofiber size, high surface hardness, hydrophilic properties and negative surface charge can increase the ability of wound healing.
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