Analisis Penambahan B-TCP dan PEG pada Hidrogel PVA terhadap Morfologi dan Sifat Mekanik Produk Injectable Biomaterial

Khoirunnisa, Syahrin Haifa (2024) Analisis Penambahan B-TCP dan PEG pada Hidrogel PVA terhadap Morfologi dan Sifat Mekanik Produk Injectable Biomaterial. Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Injectable biomaterial berbasis hidrogel, merupakan kandidat yang sesuai untuk prosedur minimally invasive surgery. PVA berbasis hidrogel memiliki biokompatibilitas yang baik, non-imunogenik, dan non-toksik. Penambahan β-TCP diperlukan untuk meningkatkan sifat mekanik, bioaktivitas, daya lekat di sekitar jaringan, dan meningkatkan adhesi serta proliferasi sel. PEG sebagai material termoresponsif juga ditambahkan, karena memiliki stabilitas mekanik yang dapat memperkuat keseluruhan struktur hidrogel, sehingga memungkinkan untuk mempertahankan bentuk hidrogel dan integritasnya selama injeksi. Tujuan penelitian ini adalah menganalisis pengaruh penambahan β-TCP dan poly(ethylen glycol) terhadap morfologi, sifat mekanik, gelation time, dan setting time injectable biomaterial komposit hidrogel PVA/β-TCP/PEG. Variasi komposisi PVA yang digunakan yaitu 15 dan 20% (w/v), dengan variasi penambahan β-TCP sebesar 15, 20, dan 25% (w/t), serta PEG divariasikan sebesar 75, 80, dan 85%wt. Pada penelitian ini dilakukan beberapa karakterisasi diantaranya pengamatan visual, gelation time dan setting time. Karakterisasi sifat mekanik menggunakan universal testing machine untuk mengetahui kekuatan tekan dan injectability. Pengujian XRD dan FTIR dilakukan untuk menganalisa struktur komposit hidrogel. SEM-EDX digunakan untuk menganalisa morfologi dan interface β-TCP dengan matriks. Hasil penelitian menunjukkan bahwa penambahan β-TCP dan PEG berpengaruh terhadap gelation time, dan setting time, sifat mekanik, dan morfologi injectable biomaterial untuk aplikasi cancellous bone. Komposit hidrogel PVA15/PEG85TCP15 yang memiliki ukuran porositas 262.33 μm, compressive strength 29.52 MPa, modulus tekan 33.35 MPa, tekanan injektabilitas 23.4 N, waktu gelasi 18 menit, dan setting time 4 jam 48 menit dimana nilai ini mendekati kriteria sebagai injectable scaffold untuk cancellous bone.
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Injectable biomaterials based on hydrogels are suitable candidates for minimally invasive surgery procedures. PVA-based hydrogels have good biocompatibility, are non-immunogenic and non-toxic. The addition of β-TCP is necessary to improve mechanical properties, bioactivity, adhesion around tissues, and enhance adhesion and cell proliferation. PEG as a thermoresponsive material was also added, because it has mechanical stability that can strengthen the overall structure of the hydrogel, making it possible to maintain the shape of the hydrogel and its integrity during injection. The purpose of this study was to analyze the effect of the addition of β-TCP and poly(ethylen glycol) on morphology, mechanical properties, gelation time, and setting time of injectable biomaterial composite hydrogel PVA/β-TCP/PEG. PVA composition variations used were 15 and 20% (w/v) , with β-TCP addition variations of 15, 20, and 25% (w/t), and PEG varied by 75, 80, and 85%wt. In this study, several characterizations were carried out including visual observation, gelation time and setting time. Characterization of mechanical properties using universal testing machine to determine compressive strength and injectability. XRD and FTIR tests were conducted to analyze the structure of the hydrogel composite. SEM-EDX was used to analyze the morphology and interface of β-TCP with the matrix. The results showed that the addition of β-TCP and PEG affected the gelation time, setting time, mechanical properties, and morphology of injectable biomaterials for cancellous bone applications. The PVA15/PEG85TCP15 hydrogel composite has a porosity size of 262.33 μm, compressive strength of 29.52 MPa, compressive modulus of 33.35 MPa, injectability pressure of 23.4 N, gelation time of 18 minutes, and setting time of 4 hours 48 minutes which is close to the criteria as an injectable scaffold for cancellous bone.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	β-TCP, Hidrogel, Injectable Biomaterial, Poly(ethylene glycol), Poly(vinyl alcohol), Hydrogel
Subjects:	Q Science > QC Physics > QC173.4.C63 Composite materials Q Science > QD Chemistry > QD481 Chemical structure. T Technology > T Technology (General) > TA404 Materials--Biodegradation T Technology > TP Chemical technology > TP1140 Polymers
Divisions:	Faculty of Industrial Technology and Systems Engineering (INDSYS) > Material & Metallurgical Engineering > 28201-(S1) Undergraduate Thesis
Depositing User:	Syahrin Haifa Khoirunnisa
Date Deposited:	05 Feb 2024 15:49
Last Modified:	05 Feb 2024 15:49
URI:	http://repository.its.ac.id/id/eprint/106119

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