Sari, Desi Permata (2024) Produksi Nanocrystalline Cellulose (NCC) dari Limbah Sayur Kubis (Soft Lignocellulosic Material) sebagai Drug Carrier Menggunakan Metode High-Speed Mixer Cutter (HSMC) dan Steam Explosion. Masters thesis, Institut Teknologi Sepuluh Nopember.
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Abstract
Limbah sayuran kubis merupakan salah satu bahan yang mempunyai potensi besar untuk dimanfaatkan sebagai bahan baku pembuatan Nanocrystalline Cellulose (NCC) yang dapat diaplikasikan di berbagai sektor, khususnya di bidang kesehatan dan pengobatan. Penelitian ini berfokus pada produksi NCC untuk aplikasi penghantaran obat dengan laju disolusi terkontrol, terutama untuk obat anti inflamasi (NSAID). Proses produksinya meliputi perlakuan mekanis menggunakan High-Speed Mixer Cutter (HSMC), dilanjutkan dengan delignifikasi tanpa menggunakan menggunakan NaOH dan menggunakan NaOH konsentrasi rendah serta bleaching dengan 1 % NaOCl. Steam explosion juga dilakukan untuk menghilangkan hemiselulosa secara fisika menggunakan suhu yang bervariasi. Sampel yang menjalani perlakuan mekanis menggunakan HSMC menunjukkan penurunan kandungan lignin dari 13,8% menjadi 1,23% dan peningkatan kandungan selulosa dari 29,53% menjadi 53,56%. Setelah dilakukan proses delignifikasi dan bleaching, kadar lignin mengalami penurunan menjadi 0,14%, sedangkan kadar selulosa meningkat menjadi 56,25%. Produksi NCC dicapai melalui ledakan uap sehingga menghasilkan kandungan selulosa tertinggi sebesar 70,11% pada suhu 180°C.
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Cabbage vegetable waste is a material with significant potential for use as a raw material in the production of Nanocrystalline Cellulose (NCC), particularly applicable in various sectors, especially in health and medicine. This research focuses on producing NCC for drug delivery applications with controlled dissolution rates, specifically targeting anti-inflammatory drugs (NSAIDs). The production process involves mechanical treatment using a High-Speed Mixer Cutter (HSMC), followed by delignification without NaOH and with low-concentration NaOH, and bleaching with 1% NaOCl. Steam explosion was also conducted to physically remove hemicellulose at varying temperatures. Samples subjected to mechanical treatment using HSMC exhibited a decrease in lignin content from 13.8% to 1.23% and an increase in cellulose content from 29.53% to 53.56%. Following delignification and bleaching, the lignin content decreased to 0.14%, while the cellulose content increased to 56.25%. NCC production was achieved through steam explosion, resulting in the highest cellulose content of 70.11% at a temperature of 180°C.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | RTK 620.115 DES p 2024 |
| Uncontrolled Keywords: | Cabbage Vegetable Waste, Nanocrystalline Cellulose, High-Speed Mixer Cutter, Drug Carrier. Limbah Kubis, Nanocrystalline Cellulose, High-Speed Mixer Cutter, Drug Carrier. |
| Subjects: | T Technology > TP Chemical technology > TP248 Nanogels. Nanoparticles. |
| Divisions: | Faculty of Industrial Technology > Chemical Engineering > 24101-(S2) Master Thesis |
| Depositing User: | Desi Permata Sari |
| Date Deposited: | 12 Feb 2024 00:24 |
| Last Modified: | 21 Nov 2024 08:10 |
| URI: | http://repository.its.ac.id/id/eprint/106901 |
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