Pengaruh Perbedaan Konduktivitas Cairan Dialisat Terhadap Hematologi Hewan Uji Tikus Putih (Rattus norvegicus)

Fadhila, Rizqi (2024) Pengaruh Perbedaan Konduktivitas Cairan Dialisat Terhadap Hematologi Hewan Uji Tikus Putih (Rattus norvegicus). Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Chronic Kidney Disease (CKD) atau Penyakit Ginjal Kronik (PGK) merupakan penyakit kelainan ginjal, fungsi ginjal, dan penurunan progresif dalam laju filtrasi glomerulus atau Glomerulus Filtration Rate (GFR) dengan penanganan yang dapat diberikan yaitu Hemodialisis. Konduktivitas merupakan besaran fisik untuk mengukur konsentrasi dari kadar bahan kimia terlarut dalam cairan dialisat. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh perbedaan konduktivitas cairan dialisat terhadap kadar hemoglobin, hematokrit, jumlah eritrosit, dan jumlah leukosit diferensial hewan uji (Rattus norvegicus). Metode yang digunakan dalam penelitian ini yaitu dilakukan secara sub-kronis selama 28 hari dan injeksi (IV) menggunakan 3 cairan dialisat dengan konduktivitas berbeda. Perhitungan kadar Hemoglobin menggunakan Hb meter, perhitungan jumlah sel eritrosit menggunakan Hemacytometer, dan perhitungan jumlah sel leukosit diferensial menggunakan metode apusan darah. Hasil dari penelitian ini menunjukkan bahwa perbedaan konduktivitas cairan dialisat menyebabkan fluktuasi kadar hemoglobin dan hematokrit serta jumlah eritrosit. Perbedaan konduktivitas cairan dialisat juga menyebabkan peningkatan jumlah leukosit diferensial jenis basofil dan limfosit dan tidak mempengaruhi jumlah eosinofil, neutrofil, dan monosit ditandai dengan jumlah yang masih dalam kisaran normal.
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Chronic Kidney Disease (CKD) or Chronic Kidney Disease (CKD) is a disease of kidney disorders, kidney function, and a progressive decrease in the glomerular filtration rate (GFR) with treatments that can be given, namely Hemodialysis. Conductivity is a physical quantity to measure the concentration of dissolved chemicals in dialysate. The purpose of this study was to determine the effect of differences in dialysate fluid conductivity on hemoglobin levels, hematocrit, erythrocyte count, and differential leukocyte count of test animals (Rattus norvegicus). The method used in this study is sub-chronic for 28 days and injection (IV) using 3 dialysate fluids with different conductivities. Then the calculation of Hemoglobin level using Hb meter, calculation of erythrocyte cell count using Hemacytometer, and calculation of differential leukocyte cell count using blood smear method. The results of this study show that differences in the conductivity of dialysate fluid cause fluctuations in hemoglobin and hematocrit levels and the number of erythrocytes. The difference in dialysate fluid conductivity also causes an increase in the number of differential leukocytes of basophil and lymphocyte types and does not affect the number of eosinophils, neutrophils, and monocytes characterized by numbers that are still within the normal range.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	Dialisat, Hematologi, Hemodialisis, Konduktivitas Conductivity, Dialysis, Hematology, Hemodialysis
Subjects:	Q Science > QH Biology > QH301 Biology Q Science > QH Biology > QH541.15.T68 Toxicity testing
Divisions:	Faculty of Science and Data Analytics (SCIENTICS) > Biology > 46201-(S1) Undergraduate Thesis
Depositing User:	Rizqi Fadhila
Date Deposited:	13 Feb 2024 15:47
Last Modified:	13 Feb 2024 15:47
URI:	http://repository.its.ac.id/id/eprint/106985

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