Inovasi Produk dan Proses Pembuatan Bone Graft Dental Implant Berbasis Komposit Nano-Hidroksiapatit Cangkang Rajungan dan Polycaprolactone

Aska, Silma Elvaretta and Ma’mun, Ummu Zahroh and Rizqiyah, Vita Fatichah and Ramadhan, Haykal Nur Fajri and Kamilah, Villia Lidzati and Nugroho, M Aldi and Rosanti, Maharani Sugito and Gumelar, Tobing and Venanto, Dimas Gilang (2024) Inovasi Produk dan Proses Pembuatan Bone Graft Dental Implant Berbasis Komposit Nano-Hidroksiapatit Cangkang Rajungan dan Polycaprolactone. Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Kebutuhan akan bone graft di Indonesia mengalami peningkatan yang signifikan, terutama seiring dengan meningkatnya pencangkokan gigi atau guided bone regeneration (GBR). Namun, sebagian besar bahan cangkok tulang komersial tidak memenuhi sifat-sifat ideal bone graft, terutama untuk kasus cacat atau atrofi tulang yang besar dan vertikal. Oleh karena itu, penggunaan hidroksiapatit sebagai material implan menjadi pilihan, meskipun rentan terhadap kerapuhan (brittle), sehingga diperlukan modifikasi struktur dengan pembentukan komposit PCL/HAp. Polimer Polikaprolakton (PCL) dipilih karena tahan korosi, degradasi lambat, biokompatibel, dan tergolong dalam kategori medical grade. Pabrik direncanakan berlokasi di Cirebon, Jawa Barat, guna memastikan ketersediaan bahan baku yang optimal, yakni limbah cangkang rajungan. Diproyeksikan bahwa limbah ini mencapai sekitar 4,4 ton per hari yang berpotensi memenuhi kebutuhan implan gigi sebanyak 76 buah/hari di Indonesia dan 770 ribu/hari di Asia Pasifik pada tahun 2030. Dengan demikian, pabrik akan memiliki kapasitas produksi harian sebesar 2 ton hidroksiapatit, yang sebagian akan digunakan untuk memproduksi 29 ribu buah implan gigi setiap hari. Inovasi ini meliputi simulasi proses, analisis neraca massa dan energi, serta konsiderasi spesifikasi alat. Berdasarkan analisis ekonomi, diestimasikan mendapat net income sebesar 60,6 triliun setelah 30 tahun beroperasi dengan nilai NPV mencapai 15,7 triliun rupiah. Sehingga, pabrik ini layak didirikan karena nilai IRR sebesar 43,25% yang lebih besar dari suku bunga bank.
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The demand for bone grafts in Indonesia has seen a significant increase, particularly with the rise in dental grafting or guided bone regeneration (GBR) procedures. However, most commercial bone graft materials do not meet the ideal properties required for grafts, especially in cases of large or vertical bone defects and atrophy. As a result, the use of hydroxyapatite as an implant material has become a preferred choice, despite its brittleness, necessitating structural modifications by forming a PCL/HAp composite. Polycaprolactone (PCL) is chosen due to its corrosion resistance, slow degradation, biocompatibility, and medical-grade classification. The planned factory will be located in Cirebon, West Java, to ensure the optimal availability of raw materials, specifically crab shell waste. This waste is projected to reach about 4.4 tons per day, potentially meeting the need for 76 dental implants per day in Indonesia and 770,000 per day in the Asia Pacific region by 2030. Consequently, the factory will have a daily production capacity of 2 tons of hydroxyapatite, which some of them will be used to produce 29,000 dental implants each day. The innovation includes process simulation, mass and energy balance analysis, and equipment specification considerations. Based on economic analysis, the factory is estimated to generate a net income of 67 trillion rupiahs after 30 years of operation, with an NPV (Net Present Value) of 17 trillion rupiahs. Therefore, the factory is deemed viable with an IRR (Internal Rate of Return) of 47.68%, which is significantly higher than the bank interest rate.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	Bone Graft, Inovasi Pabrik, Nano-Hidroksiapatit, Polikaprolakton, Innovation Process, Nano-Hydroxyapatite, Polycaprolactone
Subjects:	T Technology > TP Chemical technology > TP155.7 Chemical processes.
Divisions:	Faculty of Vocational > 24305-Industrial Chemical Engineering Technology
Depositing User:	M ALDI NUGROHO
Date Deposited:	25 Jul 2024 03:09
Last Modified:	25 Jul 2024 03:43
URI:	http://repository.its.ac.id/id/eprint/108866

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