Pembuatan Nanopartikel Kurkumin menggunakan Antisolvent tersonikasi

fatimah, siti (2024) Pembuatan Nanopartikel Kurkumin menggunakan Antisolvent tersonikasi. Masters thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Kurkumin (diferuloylmethane) merupakan senyawa polifenolik yang diekstrak dari
rimpang kunyit (Curcuma longa). Kurkumin banyak ditemukan di Indonesia yang
memiliki sifat farmakologis terutama dalam bidang terapeutik. Namun,
pemanfaatan kurkumin masih terbatas karena sifat kelarutan dalam air yang rendah
dan bioavailabilitas yang buruk. Bioavailabilitas dan kelarutan kurkumin dapat
ditingkatkan dengan pembuatan nanosuspensi menggunakan bantuan sonikasi.
Oleh karena itu, penelitian ini bertujuan untuk mengetahui pengaruh proses
antisolvent tersonikasi terhadap properti nanopartikel kurkumin untuk
meningkatkan kelarutan serta bioavailabilitasnya. Tahapan awal pada pembuatan
nanopartikel kurkumin dengan metode wet-milling dengan bantuan gelombang
ultrasonik yaitu kurkumin dilarutkan dalam pelarut yang mudah menguap
kemudian diinjeksikan ke dalam air panas (antisolvent) dengan pengadukan
konstan selama kondisi tersonikasi. Selanjutnya, larutan dipekatkan di bawah
tekanan rendah dan dikeringkan dengan proses freeze drying untuk mendapatkan
hasil berupa serbuk lalu dikarakteristirisasi. Hasil menunjukkan perubahan pada
properties kurkumin yaitu perubahan warna dari kuning tua menjadi kuning muda
atau transparan setelah diproses. Konsentrasi kelarutan kurkumin dalam air
meningkat seiring dengan lamanya waktu kontak sonikasi. Spectra FTIR
mengonfirmasi keberadaan semua gugus fungsional dari native kurkumin dan
pelebaran puncak yang mengindikasikan form 2 ortorombik yang lebih amorf. X�ray menunjukkan peak kristal dari native kurkumin dan perubahan peak setelah
diproses yang merupakan struktur form 2. Analisa SEM menunjukkan morfologi
kurkumin setelah diproses terbentuk partikel-partikel yang lebih kecil dengan rata�rata ukuran partikel menurun menjadi 276 nm. Nanopartikel kurkumin dengan
bentuk struktur ortorombik menfasilitasi interaksi molekul kurkumin dengan
radikal bebas lebih efektif sehingga sifat fungsional antioksidan kurkumin menjadi
sangat kuat.
Kata Kunci : Kurkumin, Solubility, Sonikasi, Bioavailabilitas, Nanopartikel
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Curcumin (diferuloylmethane) is a polyphenolic compound extracted from turmeric
rhizomes (Curcuma longa). Curcumin is often found in Indonesia and has
pharmacological properties, especially in the therapeutic field. However, the use of
curcumin is still limited due to its low water solubility and poor bioavailability. The
bioavailability and solubility of curcumin can be increased by making
nanosuspensions using sonication. Therefore, this research aims to determine the
effect of the sonicated antisolvent process on the properties of curcumin
nanoparticles to increase their solubility and bioavailability. The initial stage in
making curcumin nanoparticles using the wet-milling method with the help of
ultrasonic waves is that the curcumin is dissolved in a volatile solvent and then
injected into hot water (an antisolvent) with constant stirring during sonication
conditions. Next, the solution was concentrated under low pressure and dried using
a freeze-drying process to obtain a powder, which was then characterized. The
results show changes in the properties of curcumin, namely a change in color from
dark yellow to light yellow or transparent after processing. The solubility content of
curcumin in water increases with the length of the sonication contact time. The FTIR
spectra confirmed the presence of all functional groups of native curcumin, and
peak broadening indicated the more amorphous orthorhombic form 2. The X-ray
shows the crystal peak of native curcumin and changes in the peak after processing,
which is form 2. SEM analysis shows that the morphology of curcumin after
processing forms smaller particles, with the average particle size decreasing to 268
nm. Curcumin nanoparticles with an orthorhombic structure facilitate the
interaction of curcumin molecules with free radicals more effectively, so that the
functional antioxidant properties of curcumin become very strong.
Keywords : Curcumin, Solubility, Sonication, Bioavailability, Nanoparticles

Item Type:	Thesis (Masters)
Uncontrolled Keywords:	Kurkumin, Solubility, Sonikasi, Bioavailabilitas, Nanopartikel Curcumin, Solubility, Sonication, Bioavailability, Nanoparticles
Subjects:	Q Science > QD Chemistry > QD471 Chemical compounds - Structure and formulas R Medicine > R Medicine (General) T Technology > TP Chemical technology > TP155.7 Chemical processes.
Divisions:	Faculty of Industrial Technology and Systems Engineering (INDSYS) > Chemical Engineering > 24101-(S2) Master Thesis
Depositing User:	Siti Fatimah
Date Deposited:	09 Aug 2024 02:17
Last Modified:	09 Aug 2024 02:17
URI:	http://repository.its.ac.id/id/eprint/113665

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