Astuti, Chrisna Juli (2022) Analisis Pengaruh Variasi Surfaktan Terhadap Karakteristik Ferro Fluid Berbasis Nanopartikel Magnetit Untuk Aplikasi Terapi Hipertermia. Other thesis, Institut Teknologi Sepuluh Nopember.
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Abstract
Superparamagnetic iron oxide nanoparticles merupakan salah satu nanopartikel magnetik yang memiliki potensi yang menjanjikan dan saat ini banyak dikembangkan untuk aplikasi biomedis, salah satunya aplikasi terapi hipertermia. Salah satu cara untuk melakukan terapi hipertermia dengan menggunakan metode material ferrofluid berbasis magnetit nanopartikel. Dalam penelitian ini, material nanopartikel magnetit disintesis menggunakan metode kopresipitasi dengan prekursor FeCl2 dan FeCl3, dimana FeCl2 didapatkan melalui steel wool dan HCl yang dilarutkan. Campuran prekursor dititrasi dengan larutan basa kuat seperti NH4OH serta mengontrol rasio molar Fe2+/Fe3+ pada 1:2. Dengan penambahan surfaktan ke dalam nanopartikel oksida besi dapat mengurangi tingkat aglomerasi, memberi sifat biokompaktibel, dan mengontrol ukuran partikel. Dalam penelitian ini digunakan variasi penambahan surfaktan asam glutamat, asam oleat, dan polyethylene glycol-6000 dengan rasio 2:5. Selanjutnya sampel dikarakterisasimenggunakan XRD, FTIR, SEM, PSA hidrofobisitas, surface tension, VSM, dan medan magnet. Analisis XRD menunjukan bahwa nanopartikel memiliki struktur kristal kubik dan ukuran kristal antara 8.9 – 9.7 nm, serta penambahan surfaktan tidak menggeser puncak difraksi dan secara signifikan tidak mempengaruhi struktur kristal. Karakterisasi FTIR dengan penambahan surfaktan memunculkan gugus fungsi baru pada nanopartikel selain gugus fungsi OH dan Fe-O. Pada uji SEM dengan penambahan surfaktan secara konstan memperbesar ukuran partikel dari nanopartikel Fe3O4. Semua nanopartikel Fe3O4 menunjukan sifat superparamagnetik terbukti dengan terbentuknya kurva magnetisasi pada pengujian VSM yang tidak menunjukan adanya magnet sisa (remanence), dan membentuk kurva S dengan nilai magnetisasi antara 38.10-40.08 emu/g. Nanopartikel di dalam cairan pembawa terbukti sesuai dengan surfaktan yang digunakan, pada pengujian hidrofobisitas nanopartikel dengan surfaktan asam oleat bersifat hidrofobik dengan sudutkontak 132.65o dan memiliki sifat hidrofilik dengan sudut kontak 36.07o -49.65o pada surfaktan asam oleat dan asam glutamat. Dengan uji surface tension didapatkan penambahan surfaktan asam oleat terbukti menurunkan tegangan permukaan dan memiliki nilai sebesar 59.84 mN/m. Ferro fluid memiliki potensi untuk aplikasi terapi hipertermia, terbukti mampu menghasilkan energi panas sebesar 29.3-31.9oC pada saat dikenai medan magnet eksternal dengan grafik temperatur terhadap waktu terus mengalami kenaikan pada saat diberikan arus listrik. Dari kenaikan temperatur didapatkan nilai SAR sampel sebesar 0.0627 – 0.155 W/g
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Superparamagnetic iron oxide nanoparticles are one of the magnetic nanoparticles that have promising potential and are currently being developed for biomedical applications, one of which is hyperthermia therapy. One way to do hyperthermia therapy is using a ferrofluid material method based on magnetite nanoparticles. In this study, iron oxide nanoparticles were synthesized using the coprecipitation method with FeCl2 and FeCl3precursors, where FeCl2 was obtained through steel wool and dissolved HCl. The precursor mixture is titrated with a strong base such as NH4OH and controls the Fe2+/Fe3+ molar ratio at 1:2. With the addition of surfactants into iron oxide nanoparticles can reduce the level of agglomeration, provide biocompatible properties, and control particle size. In this study, variations of the addition of glutamic acid, oleic acid, and polyethylene glycol-6000 surfactants were used in a 2:5 ratio. Furthermore, the samples were characterized using XRD, FTIR, SEM, PSA hydrophobiity, surface tension, VSM, and magnetic fields. XRD analysis showed that the nanoparticles had a cubic crystal structure and crystal size between 8.9 – 9.7 nm, and the addition of surfactants did not shift the diffraction peaks and did not significantly affect the crystal structure. The characterization of FTIR with the addition of surfactants gave rise to new functional groups in nanoparticles other than the OH and Fe-O functional groups. In the SEM test, the addition of surfactants constantly increases the particle size of Fe3O4 nanoparticles. All Fe3O4 nanoparticles showed superparamagnetic properties as evidenced by the formation of a magnetization curve in the VSM test which did not show any residual magnetism, and formed an S curve with a magnetization value between 38.10-40.08 emu/g. The nanoparticles in the carrier liquid were proven to be compatible with the surfactant used, in the hydrophobicity test the nanoparticles with oleic acid surfactant were hydrophobic with a contactangle of 132.65o and had hydrophilic properties with a contact angle of 36.07o - 49.65o in oleic acid and glutamic acid surfactants. With the surface tension test, it was found that the addition of oleic acid surfactant was proven to reduce the surface tension and had a value of 59.84 mN/m. Ferro fluid has the potential for hyperthermia therapy applications, proven to be able to produce heat energy of 29.3-31.9oC when exposed to an external magnetic field with a graph of temperature over time that continues to increase when an electric current is applied. From the increase in temperature, the SAR value of the sample is 0.0627 – 0.155 W/g.
| Item Type: | Thesis (Other) |
|---|---|
| Additional Information: | RSMt 614.599 Ast a-1 2022 |
| Uncontrolled Keywords: | Kopresipitasi, superparmagnetik, terapi hipertermia, Coprecipitationi, hyperthermia therapy, superparmagnetic |
| Subjects: | Q Science > QR Microbiology > QR 201.T84 Tumors. Cancer |
| Divisions: | Faculty of Industrial Technology > Material & Metallurgical Engineering > 28201-(S1) Undergraduate Thesis |
| Depositing User: | Mr. Marsudiyana - |
| Date Deposited: | 17 Dec 2024 07:02 |
| Last Modified: | 17 Dec 2024 07:02 |
| URI: | http://repository.its.ac.id/id/eprint/116001 |
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