Skrining Potensi Turunan Imidazol Sebagai Obat Nano dan Evaluasi Stabilitasnya

Bahetha, Amelia (2025) Skrining Potensi Turunan Imidazol Sebagai Obat Nano dan Evaluasi Stabilitasnya. Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Obat nano memiliki potensi yang baik sebagai pengobatan kanker dengan pengobatan spesifik ditargetkan ke jaringan tumor dan pelepasan terkontrol dari obat. Penelitian ini bertujuan membuat dispersi obat nano yang berasal dari turunan imidazol yang terbukti memiliki aktivitas farmakologis yang baik untuk pengobatan kanker. Turunan imidazol yang potensial seperti 2,4,5-trifenilimidazol (IMD 1), 2-(4-nitrofenil)-4,5-difenil-1-imidazol (IMD 2), 2-(4-metoksifenil)-4,5-difenil-1H-imidazol (IMD 3) dan 4-(4,5-difenil-1-imidazol-2-il)-2-metoksifenol (IMD 4) dibuat dispersi obat nano dan dievaluasi stabilitasnya, dan didapatkan hasil sebagai berikut. Pada tahap skrining pelarut didapatkan pelarut yang cocok untuk obat nano senyawa turunan imidazol IMD 1 dan IMD 2 adalah dimetil sulfoksida (DMSO), untuk obat nano IMD 3 dan IMD 4 adalah tetrahidrofuran (THF). Skrining biopolimer sebagai pelapis yang cocok untuk obat nano turunan imidazol seperti gelatin, alginat, kitosan dan pektin juga dievaluasi dan didapatkan gelatin sebagai material pelapis yang terbaik. Dalam penelitian ini turunan imidazol yang paling potensial adalah IMD 4, karena ukuran partikelnya masih dalam rentang Enhanced Permeability and Retention (EPR) efek yakni 203,3 nm dengan konsentrasi pelapisan gelatin 25 μg/mL . Kemudian jumlah gelatin yang melapisi obat nano IMD 4 juga dievaluasi dan didapatkan bahwa jumlah gelatin yang menempel akan meningkat seiring meningkatkannya konsentrasi dan akan mencapai titik jenuh yang disebabkan oleh habisnya situs aktif pada permukaan obat nano. Pada uji stabilitas pH obat nano IMD 4 yang paling potensial masih mengalami agregrasi yakni dengan ukuran 575,1 nm pada pH 5 dan dengan ukuran 995 nm pada pH 7. Hasil akhir karakterisasi FESEM menunjukkan morfologi permukaan obat nano IMD 4 berbentuk.
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Nanodrugs have good potential as cancer treatments with specific targeted treatments to tumor tissue and controlled release from drugs. This study aims to make a nanodrug dispersion derived from the imidazole derivative which is proven to have good pharmacological activity for cancer treatment. Potential imidazole derivatives such as 2,4,5-triphenylimidazole (IMD 1), 2-(4-nitrophenyl)-4,5-diphenyl-1-imidazole (IMD 2), 2-(4-methoxyphenyl)-4,5-diphenyl-1H-imidazole (IMD 3) and 4-(4,5-diphenyl-1-imidazol-2-il)-2-methoxyphenol (IMD 4) were made nano-drug dispersions and their stability was evaluated, and the following results were obtained. At the solvent screening stage, a solvent suitable for nanodrugs derived compounds from imidazole IMD 1 and IMD 2 is dimethyl sulfoxide (DMSO), for IMD 3 and IMD 4 nanodrugs is tetrahydrofuran (THF). Screening of biopolymers as coatings suitable for imidazol-derived nanodrugs such as gelatin, alginate, chitosan and pectin was also evaluated and gelatin was obtained as the best coating material. In this study, the most potential imidazole derivative is IMD 4, because the particle size is still in the Enhanced Permeability and Retention (EPR) effect range, which is 203.3 nm with a gelatin coating concentration of 25 μg/mL. Then the amount of gelatin that coats the IMD 4 nanodrug was also evaluated and it was found that the amount of gelatin that sticks will increase as the concentration increases and will reach the saturation point caused by the depletion of the active site on the surface of the nanodrug. In the pH stability test, the most potential IMD 4 nanodrug is still aggregated, namely with a size of 575.1 nm at pH 5 and with a size of 995 nm at pH 7. The final results of FESEM characterization show the morphology of the surface of the IMD 4 nanodrug shape.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	Agregrasi, Material Pelapis, Obat Nano, Stabilitas, Turunan imidazol, Aggregation, Coating Materials, Nanodrugs, Stability, Imidazole Derivatives
Subjects:	Q Science > QD Chemistry > QD75.2 Chemistry, Analytic
Divisions:	Faculty of Science and Data Analytics (SCIENTICS) > Chemistry > 47201-(S1) Undergraduate Thesis
Depositing User:	Amelia Bahetha
Date Deposited:	01 Feb 2025 10:07
Last Modified:	01 Feb 2025 10:07
URI:	http://repository.its.ac.id/id/eprint/117370

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