Ganendra, Alif Akbar (2025) Analisis Pengaruh Jenis Solvent Dan Durasi Perendaman Sebagai Pre-Treatment Terhadap Integrasi Zno Nps Untuk Meningkatkan Sifat Antibakteri Dan Mekanik 3d Print Bone Scaffold Berbasis Pla/Zno Nps. Other thesis, Institut Teknologi Sepuluh Nopember.
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Abstract
Salah satu dari penerapan bone tissue engineering ialah bone scaffold, dimana bekerja dengan memberikan struktur kerangka tambahan pada jaringan tulang yang mengalami kerusakan untuk mempercepat regenerasi tulang yang mengalami kerusakan. Penelitian ditujukan untuk mengetahui bagaimana pengaruh dari variasi solvent dan lama perendaman terhadap integrasi ZnO NPs pada bone scaffold PLA. Metode fabrikasi yang digunakan ialah metode Fused Deposition Modelling dengan filamen polylactic acid (PLA). Bone scaffold kemudian direndam pada larutan solvent sesuai dengan variabel. ZnO NPs disintesis dengan metode microwaved assissted green synthesis menggunakan ekstrak daun eceng gondok (EDEG). ZnO NPs serbuk kemudian dilarutkan dalam larutan ethanol dan digunakan untuk perendaman bone scaffold. Penggunaan solvent 3D Printed PLA scaffold berpengaruh terhadap sifat mekanik, dan struktur morfologi dari scaffold. Hasil terbaik didapatkan dengan pelarut ethanol mendorong reorganisasi struktural melalui kristalisasi terinduksi pelarut. Pengaruh waktu perendaman pada solvent 3D Printed PLA scaffold berdasarkan hasil compressive test variasi ethanol cenderung meningkatkan sifat mekanik keduanya seiring bertambahnya waktu perendaman sesuai variasi, dengan hasil tertinggi 80.76 MPa . Pada sifat wettability variasi ethanol yang memiliki hasil membaik seiring lamanya waktu perendaman dengan hasil sudut kontak mencapai hidrofilik 84.45o.
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One of the applications of bone tissue engineering is the bone scaffold, which works by providing an additional framework structure to damaged bone tissue to accelerate its regeneration. This research aimed to determine the effect of solvent variation and immersion time on the integration of ZnO NPs into a PLA bone scaffold. The fabrication method used was Fused Deposition Modelling (FDM) with a polylactic acid (PLA) filament. The bone scaffold was then immersed in a solvent solution according to the specified variables. The ZnO NPs were synthesized using a microwave-assisted green synthesis method with water hyacinth leaf extract. The powdered ZnO NPs were then dissolved in an ethanol solution, which was used for the immersion of the bone scaffold. The use of a solvent on the 3D-printed PLA scaffold influenced its mechanical properties and morphological structure. The best results were obtained with the ethanol solvent, which promoted structural reorganization through solventinduced crystallization. Based on the compressive test results, the immersion time in the ethanol solvent tended to improve the mechanical properties as the immersion time increased, with the highest result being 80.76 MPa. Regarding the wettability properties, the ethanol variation also showed improvement with longer immersion times, achieving a hydrophilic contact angle of 84.45°.
| Item Type: | Thesis (Other) |
|---|---|
| Uncontrolled Keywords: | 3D Print, Bone Scaffold, Green Synthesis, PLA, ZnO NPs |
| Subjects: | R Medicine > RD Surgery > RD755.5.C35 Orthopedic implants. R Medicine > RD Surgery > RD755.6 Bone substitutes. T Technology > TP Chemical technology > TP1140 Polymers T Technology > TP Chemical technology > TP248 Nanogels. Nanoparticles. |
| Divisions: | Faculty of Industrial Technology and Systems Engineering (INDSYS) > Material & Metallurgical Engineering |
| Depositing User: | Alif Akbar Ganendra |
| Date Deposited: | 30 Jul 2025 10:00 |
| Last Modified: | 30 Jul 2025 10:00 |
| URI: | http://repository.its.ac.id/id/eprint/123865 |
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