Optimasi Rasio Hidroksiapatit:Kitosan:Asam Hialuronat pada Coating Implan Tulang Stainless Steel 316L Menggunakan Metode Deposisi Elektroforesis dengan Variasi Tegangan Listrik

Pratama, Muhammad Farhan Ismu and Faiqotin, Fatkhulil Jannah Nur (2025) Optimasi Rasio Hidroksiapatit:Kitosan:Asam Hialuronat pada Coating Implan Tulang Stainless Steel 316L Menggunakan Metode Deposisi Elektroforesis dengan Variasi Tegangan Listrik. Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Fraktur atau patah tulang merupakan masalah kesehatan serius yang prevalensinya terus meningkat, terutama akibat trauma langsung seperti kecelakaan transportasi. Implan tulang, seperti Stainless Steel 316L, sering digunakan untuk penyembuhan fraktur, namun berisiko menyebabkan infeksi (osteomielitis) dan pelepasan ion toksik akibat korosi. Untuk itu, pelapisan implan dengan biomaterial Hidroksiapatit (HAp), Kitosan (CS), dan Asam Hialuronat (HA) menjadi solusi menjanjikan. HAp meningkatkan bioaktivitas dan biokompatibilitas, CS memperkuat ikatan HAp, sementara HA memberikan sifat antibakteri. Tujuannya adalah untuk mengetahui pengaruh perbandingan rasio HAp:CS:HA dan variasi tegangan listrik terhadap gugus fungsional yang terbentuk, keseragaman lapisan secara visual, bioaktivitas, laju degradasi, antibakteri, dan laju korosi.

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Fractures are a serious health problem with increasing prevalence, especially due to direct trauma such as transportation accidents. Bone implants, such as 316L Stainless Steel, are often used for fracture healing, but are at risk of infection (osteomyelitis) and release of toxic ions due to corrosion. For this reason, implant coating with biomaterials Hydroxyapatite (HAp), Chitosan (CS), and Hyaluronic Acid (HA) is a promising solution. HAp enhances bioactivity and biocompatibility, CS strengthens HAp bonding, while HA provides antibacterial properties. The objective was to determine the effect of HAp:CS:HA ratio and electrical voltage variation on the functional groups formed, visual coating uniformity, bioactivity, degradation rate, antibacterial, and corrosion rate.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	Pelapis Implan, Hidroksiapatit:Kitosan:Asam Hialuronat, EPD, Coating Implant. Hydroxyapatite:Chitosan:Hyaluronic Acid, EPD
Subjects:	R Medicine > RD Surgery > RD755.5.C35 Orthopedic implants.
Divisions:	Faculty of Vocational > Industrial Chemical Engineering
Depositing User:	Muhammad Farhan Ismu P
Date Deposited:	01 Aug 2025 03:44
Last Modified:	01 Aug 2025 03:44
URI:	http://repository.its.ac.id/id/eprint/124570

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