Sintesis Ligan Turunan Hidrazon Dan Kompleks Nikel(II)-2-Hidroksibenziliden-4-Metilbenzohidrazida Sebagai Agen Antibakteri

Jawahiruddin, Muhammad Akmal Jawahiruddin (2025) Sintesis Ligan Turunan Hidrazon Dan Kompleks Nikel(II)-2-Hidroksibenziliden-4-Metilbenzohidrazida Sebagai Agen Antibakteri. Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Penelitian tentang senyawa antibakteri aktif menjadi masalah yang serius akhir-akhir ini. Hal itu juga disebabkan munculnya infeksi bakteri sehingga perlu dilakukan pengembangan alternatif agen antibakteri. Perkembangan dalam penelitian agen antibakteri yang berbasis logam telah cukup luas untuk dapat diteliti lebih lanjut melihat potensinya menjadi agen antibiotik alternatif. Selain itu, senyawa koordinasi berbasis logam dapat meminimalkan efek samping dan meningkatkan efek farmakologis. Pada penelitian ini, telah berhasil disintesis ligan 2-hidroksibenziliden-4-metilbenzohidrazida berupa padatan polikristalin berwarna putih. Kompleks Ni(II)-2-hidroksibenziliden-4-metilbenzohidrazida (padatan berwarna hijau) berhasil disintesis pula yang diperoleh dari reaksi ion Ni(II) dengan ligan 2-hidroksibenziliden-4-metilbenzohidrazida dengan perbandingan mol logam : ligan yaitu 1:2. Ligan dan kompleks Ni(II) kemudian dilakukan karakterisasi, analisis, dan uji antibakteri terhadap bakteri Staphylococcus aureus dan Escherichia coli. Karakterisasi NMR (Nuclear Magnetic Resonance) untuk ligan menginformasikan bahwa jumlah dan jenis dari hidrogen maupun karbon sudah sesuai dengan struktur ligan. Hasil karakterisasi UV-Vis menunjukkan kompleks menyerap sinar UV-Vis pada panjang gelombang 326–409 nm. Hasil karakterisasi FTIR (Fourier Transform Infra Red) menunjukkan adanya ikatan koordinasi dari Ni-Cl, Ni-N, dan Ni-O. Hasil itu didukung oleh karakterisasi TGA (Thermogravimetric Analyzer) yang menginformasikan kompleks terdekomposisi pada suhu 29–141 °C. Karakterisasi sampel dengan XRD (X-Ray Diffraction) powder menunjukkan bahwa kompleks memiliki struktur kristal triklinik. Uji antibakteri dilakukan dengan metode difusi cakram yang menghasilkan nilai rata-rata zona inhibisi dari kompleks Ni(II)-2-hidroksibenzilidena-4-metilbenzohidrazida adalah 12,25 ± 1,05 mm pada S. aureus dan 14,85 ± 0,05 mm pada E. coli.
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Research on active antibacterial compounds has become a serious problem recently. It is also due to the emergence of bacterial infections that it is necessary to develop alternative antibacterial agents. Developments in the research of metal-based antibacterial agents have been extensive enough to be investigated further to see their potential to become alternative antibiotic agents. In addition, metal-based coordination compounds can minimize side effects and improve pharmacological effects. In this study, 2-hydroxybenzylidene-4-methylbenzohydrazide ligand has been successfully synthesized in the form of white polycrystalline solid. The Ni(II)-2-hydroxybenzylidene-4-methylbenzohydrazide complex (green solid) was also successfully synthesized from the reaction of Ni(II) ions with 2-hydroxybenzyliden-4-methylbenzohydrazide ligand with a mole ratio of metal: ligand of 1:2. The ligands and Ni(II) complexes were then subjected to characterization, analysis, and antibacterial tests against Staphylococcus aureus and Escherichia coli bacteria. NMR (Nuclear Magnetic Resonance) characterization for the ligand informed that the amount and type of hydrogen and carbon were in accordance with the spectra. UV-Vis characterization results showed that the complex absorbed UV-Vis light at a wavelength of 326–409 nm. FTIR (Fourier Transform Infra Red) characterization results showed the presence of coordination bonds from Ni-Cl, Ni-N, and Ni-O. The results were supported by TGA (Thermogravimetric Analyzer) characterization which informed that the complex decomposed at a temperature of 29-141 °C. Characterization of the sample with XRD (X-Ray Diffraction) powder showed that the complex has a triclinic crystal structure. Antibacterial test was conducted by disc diffusion method which resulted in the mean value of inhibition zone of Ni(II)-2-hydroxybenzylidene-4-methylbenzohydrazide complex was 12.25 ± 1.05 mm on S. aureus and 14.85 ± 0.05 mm on E. coli.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	Antibakteri, Escherichia coli, Hidrazon, Kompleks Ni(II), Staphylococcus aureus. Antibacterial, Escherichia coli, Hydrazone, Ni(II) Complexes, Staphylococcus aureus.
Subjects:	Q Science > QD Chemistry > QD251.2 Chemistry, Organic. Biochemistry
Divisions:	Faculty of Science and Data Analytics (SCIENTICS) > Chemistry > 47201-(S1) Undergraduate Thesis
Depositing User:	Muhammad Akmal Jawahiruddin
Date Deposited:	04 Aug 2025 07:52
Last Modified:	04 Aug 2025 07:52
URI:	http://repository.its.ac.id/id/eprint/124609

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