Sintesis Hydrogel PVA/Cellulose/AgNPs-Curcumin Dengan Penambahan Tranexamid Acid (TXA) Melalui Metode Freeze Thawing Untuk Aplikasi Wound Dressing

Ramadhani, Tyara Nor and Rohim, Fathor (2025) Sintesis Hydrogel PVA/Cellulose/AgNPs-Curcumin Dengan Penambahan Tranexamid Acid (TXA) Melalui Metode Freeze Thawing Untuk Aplikasi Wound Dressing. Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Luka dekubitus merupakan masalah kesehatan serius di Indonesia dengan prevalensi mencapai 33,3%, jauh lebih tinggi dibandingkan rata-rata Asia Tenggara. Angka yang tinggi ini menunjukkan urgensi peningkatan perawatan luka, terutama mengingat dampak buruk jika tidak ditangani dengan baik. Secara global, masalah luka kronis semakin mengkhawatirkan. Di Amerika Serikat, sekitar 8,2 juta pasien menderita luka kronis dengan biaya perawatan mencapai 28,1 hingga 96,8 miliar USD per tahun. Proses penyembuhan luka kronis seringkali lambat dan berisiko komplikasi, terutama pada pasien luka kaki diabetik, dimana hanya 33,9% yang sembuh dalam tiga bulan, dan 19,1% menjalani amputasi minor. Keterbatasan bahan perawatan luka konvensional, seperti kapas dan kasa, yang memiliki kapasitas antimikroba rendah serta risiko resistensi bakteri, mendorong pengembangan solusi inovatif. Salah satu terobosan terbaru adalah penggunaan hidrogel berbasis Polyvinyl Alcohol (PVA) yang dimuat dengan ekstrak herbal antimikroba, yang diperkuat dengan Cellulose dan distabilkan oleh Nanopartikel Perak (AgNPs) dan Curcumin. Penelitian ini bertujuan untuk mensintesis hidrogel PVA/Cellulose/AgNPs-Curcumin dengan penambahan Tranexamid Acid (TXA) menggunakan metode freeze-thawing untuk aplikasi wound dressing. Nanofiber ini menawarkan keunggulan seperti porositas tinggi, struktur mirip matriks ekstraseluler, serta kemampuan untuk membawa agen bioaktif, yang dapat mempercepat penyembuhan luka dan mencegah infeksi. Kombinasi TXA dan Curcumin juga memberikan efek anti-inflamasi serta mendukung regenerasi jaringan.

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Pressure ulcers represent a significant health issue in Indonesia, with a prevalence rate of 33.3%, much higher than the Southeast Asian average. This high rate underscores the urgent need for improved wound care, especially considering the detrimental effects of untreated or poorly managed wounds. On a global scale, chronic wounds are also increasingly concerning. In the United States, around 8.2 million patients suffer from chronic wounds, with healthcare costs reaching $28.1 to $96.8 billion per year. The healing process for chronic wounds is often slow and prone to complications, particularly in diabetic foot ulcer patients, where only 33.9% heal within three months, and 19.1% undergo minor amputations. The limitations of conventional wound care materials, such as low antimicrobial capacity and the risk of bacterial resistance, have spurred the development of innovative solutions. One promising advancement is the use of Polyvinyl Alcohol (PVA)-based hydrogel loaded with antimicrobial herbal extracts, enhanced with Cellulose and stabilized with Silver Nanoparticles (AgNPs) and Curcumin. This study aims to synthesize PVA/Cellulose/AgNPs-Curcumin hydrogel with the addition of Tranexamic Acid (TXA) using the freeze-thaw method for wound dressing applications. The nanofiber offers advantages like high porosity, an extracellular matrix-like structure, and the ability to carry bioactive agents, enhancing wound healing and preventing infection. The combination of TXA and Curcumin also provides anti-inflammatory effects and promotes tissue regeneration.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	Hydrogel PVA, AgNPs-curcumin, tranexamic acid, wound dressing, freeze-thawing, antibakteri, PVA hydrogel, AgNPs-curcumin, tranexamic acid, wound dressing, freeze-thawing, antibacterial
Subjects:	T Technology > TP Chemical technology > TP1140 Polymers T Technology > TP Chemical technology > TP248 Nanogels. Nanoparticles.
Divisions:	Faculty of Vocational > Industrial Chemical Engineering
Depositing User:	Tyara Nor Ramadhani
Date Deposited:	01 Aug 2025 04:32
Last Modified:	01 Aug 2025 04:32
URI:	http://repository.its.ac.id/id/eprint/124647

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