Deteksi Parasetamol Menggunakan Screen-Printed Carbon Electrode termodifikasi Nanoselulosa-Polipirol-Single-Walled Carbon Nanotubes

Sabrina, Bunga Jasmine Nur (2025) Deteksi Parasetamol Menggunakan Screen-Printed Carbon Electrode termodifikasi Nanoselulosa-Polipirol-Single-Walled Carbon Nanotubes. Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Deteksi parasetamol telah dilakukan menggunakan Screen-Printed Carbon Electrode (SPCE) yang dimodifikasi dengan nanoselulosa-polipirol-Single-Walled Carbon Nanotubes (Nnc-Ppy- SWCNTs). Nnc-Ppy-SWCNTs diperoleh melalui dua tahap, yaitu tahap sintesis nanoselulosa dan tahap pembuatan nanoselulosa dengan polipirol dan SWCNTs. Nnc-Ppy-SWCNTs tersebut kemudian digunakan sebagai modifikasi pada permukaan elektroda kerja SPCE. Karakterisasi ukuran partikel nanoselulosa dilakukan menggunakan Particle Size Analyzer (PSA) sedangkan morfologi dan distribusi unsur pada SPCE tanpa dan dengan modifikasi (SPCE/Nnc-Ppy- SWCNTs) dianalisis menggunakan Scanning Electron Microscope – Energy Diffraction X-Ray (SEM-EDX). Data PSA menunjukkan ukuran nanoselulosa berada pada rentang antara 280 hingga 420 nm. Hasil SEM menunjukkan bahwa morfologi permukaan SPCE/Nnc-Ppy- SWCNTs terlihat lebih kasar dengan adanya partikel berbentuk bulat yang tersebar merata dibandingkan SPCE tanpa modifikasi. Evaluasi kinerja elektroda dilakukan menggunakan teknik Cyclic Voltammetry (CV) dalam PBS 0,1 M pH 7 dengan scan rate 50 mV/s. Mekanisme interaksi parasetamol dengan permukaan elektroda dikontrol oleh proses difusi pada reaksi oksidasi dan reduksi. Hasil pengujian menunjukkan bahwa SPCE/Nnc-Ppy-SWCNTs memiliki sensitivitas yang tinggi sebesar 171,724 μA/μM·cm2 pada rentang linearitas 100-800 μM. Limit deteksi (LOD) SPCE/Nnc-Ppy-SWCNTs diperoleh sebesar 10,521 μM. Uji selektivitas menunjukkan bahwa SPCE/Nnc-Ppy-SWCNTs mampu mendeteksi parasetamol secara spesifik meskipun terdapat senyawa pengganggu seperti asam askorbat, urea, asam urat, dan glukosa. Selain itu, SPCE/Nnc-Ppy-SWCNTs memiliki stabilitas sangat baik yang ditunjukkan oleh nilai Relative Standard Deviation (RSD) yang kurang dari 1% dalam 25 kali pengulangan. Hasil tersebut menunjukkan bahwa penambahan Nnc-Ppy-SWCNTs dapat meningkatkan sensitivitas untuk mendeteksi parasetamol.
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Paracetamol detection was performed using a Screen-Printed Carbon Electrode (SPCE) modified with a nanocellulose-polypyrrole-Single-Walled Carbon Nanotubes (Nnc-Ppy- SWCNTs) composite. The Nnc-Ppy-SWCNTs composite was obtained through two stages: the synthesis of nanocellulose and the preparation of the nanocellulose composite with polypyrrole and SWCNTs. The composite was then used as a modification on the working electrode surface of the SPCE. Particle size characterization of the nanocellulose was performed using a Particle Size Analyzer (PSA), while the morphology and elemental distribution on the SPCE without and with modification (SPCE/Nnc-Ppy-SWCNTs) were analyzed using a Scanning Electron Microscope – Energy Dispersive X-Ray (SEM-EDX). PSA data showed that the size of nanocellulose ranged from 280 to 420 nm. SEM results showed that the surface morphology of SPCE/Nnc-Ppy-SWCNTs appeared rougher with uniformly distributed spherical particles compared to unmodified SPCE. Electrode performance evaluation was conducted using Cyclic Voltammetry (CV) in 0.1 M PBS solution at pH 7 with a scan rate of 50 mV/s. The interaction mechanism between paracetamol and the electrode surface is controlled by diffusion processes during oxidation and reduction reactions. Test results indicate that SPCE/Nnc-Ppy-SWCNTs exhibit high sensitivity of 171.724 μA/μM·cm2 within the linearity range of 100–800 μM. The detection limit (LOD) of SPCE/Nnc-Ppy-SWCNTs was obtained at 10.521 μM. Selectivity testing showed that SPCE/Nnc-Ppy-SWCNTs can specifically detect paracetamol despite the presence of interfering compounds such as ascorbic acid, urea, uric acid, and glucose. Additionally, SPCE/Nnc-Ppy-SWCNTs exhibited excellent stability, as indicated by a Relative Standard Deviation (RSD) value of less than 1% in 25 repetitions. These results indicate that the addition of Nnc-Ppy-SWCNTs composite enhances sensitivity for paracetamol detection.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	Nanoselulosa, Parasetamol, Polipirol, Screen-Printed Carbon Electrode, Single-Walled Carbon Nanotubes. Nanocellulose, Paracetamol, Polypyrrole, Screen-Printed Carbon Electrode, Single-Walled Carbon Nanotubes.
Subjects:	Q Science > QD Chemistry > QD115 Electrochemical analysis
Divisions:	Faculty of Mathematics and Science > Chemistry > 47201-(S1) Undergraduate Thesis
Depositing User:	Bunga Jasmine Nur Sabrina
Date Deposited:	04 Aug 2025 07:41
Last Modified:	04 Aug 2025 07:41
URI:	http://repository.its.ac.id/id/eprint/125120

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