Sintesis Ligan Turunan Hidrazon dan Kompleks Kobalt(II)-2-Hidroksibenziliden-4-Metilbenzohidrazida sebagai Agen Antibakteri

Firdaus, Tsania Alfiina (2025) Sintesis Ligan Turunan Hidrazon dan Kompleks Kobalt(II)-2-Hidroksibenziliden-4-Metilbenzohidrazida sebagai Agen Antibakteri. Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Infeksi bakteri yang semakin sulit diatasi akibat resistensi antibiotik mendorong pengembangan agen antibakteri yang lebih efektif. Salah satu strategi yang dapat dilakukan adalah sintesis kompleks ion logam dengan ligan hidrazon yang berpotensi sebagai agen antibakteri. Kobalt(II) dipilih karena sifat bioesensial dan kemampuannya membentuk kompleks stabil untuk meningkatkan aktivitas antibakteri. Pada penelitian ini telah berhasil disintesis ligan 2 hidroksibenziliden-4-metilbenzohidrazida berupa padatan berwarna putih dan kompleks Co(II)-2-hidroksibenziliden-4-metilbenzohidrazida berupa padatan oranye kemerahan dengan perbandingan mol logam:ligan 1:2. Ligan dan kompleks kemudian dikarakterisasi, dianalisis, dan diuji aktivitas antibakterinya terhadap Staphylococcus aureus dan Escherichia coli menggunakan metode difusi cakram. Nilai rata-rata zona inhibisi pada ligan adalah 0 mm untuk S. aureus dan 9 ± 0 mm untuk E. coli, sedangkan pada kompleks Co(II) sebesar 12,1 ± 0 mm untuk S. aureus dan 12 ± 0,1 mm untuk E. coli. Hasil ini menunjukkan bahwa kompleks Co(II) 2-hidroksibenziliden-4-metilbenzohidrazida memiliki aktivitas antibakteri lebih baik dibandingkan ligan bebasnya, sehingga berpotensi sebagai alternatif agen antibakteri untuk mengatasi resistensi bakteri.
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Bacterial infections that are increasingly difficult to treat due to antibiotic resistance have prompted the development of more effective antibacterial agents. One promising strategy is the synthesis of metal ion complexes with hydrazone ligands, which have potential as antibacterial agents. Cobalt(II) was selected for its bioessential properties and its ability to form stable complexes that can enhance antibacterial activity. In this study, the ligand 2 hydroxybenzylidene-4-methylbenzohydrazide was successfully synthesized as a white solid, and the Co(II)-2-hydroxybenzylidene-4-methylbenzohydrazide complex was obtained as an orange-red solid with a metal-to-ligand molar ratio of 1:2. Both the ligand and the Co(II) complex were characterized, analyzed, and tested for antibacterial activity against Staphylococcus aureus and Escherichia coli using the disk diffusion method. The average inhibition zone for the ligand was 0 mm for S. aureus and 9 ± 0 mm for E. coli, while the Co(II) complex showed inhibition zones of 12,1 ± 0 mm for S. aureus and 12 ± 0,1 mm for E. coli. These results indicate that the Co(II)-2-hydroxybenzylidene-4-methylbenzohydrazide complex exhibits better antibacterial activity than the free ligand and has potential as an alternative antibacterial agent to address bacterial resistance.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	Antibakteri, Karakterisasi, Kobalt(II), Kompleks, Sintesis, Antibacterial, Characterization, Cobalt(II), Complexes, Synthesis.
Subjects:	Q Science > QD Chemistry > QD251.2 Chemistry, Organic. Biochemistry
Divisions:	Faculty of Science and Data Analytics (SCIENTICS) > Chemistry > 47201-(S1) Undergraduate Thesis
Depositing User:	Tsania Alfiina Firdaus
Date Deposited:	04 Aug 2025 07:21
Last Modified:	04 Aug 2025 07:22
URI:	http://repository.its.ac.id/id/eprint/126372

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