Electrospun Biodegradable Braids for Rib Fracture Stabilization and Sustained Drug Release

Amallia, Ulfia Nur (2025) Electrospun Biodegradable Braids for Rib Fracture Stabilization and Sustained Drug Release. Other thesis, Sepuluh Nopember Institute of Technology.

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Abstract

Rib fractures are common injuries that can lead to serious complications such as pneumothorax and infections. A frequently used treatment method is Surgical Stabilization of Rib Fractures (SSRF) using metal plates; however, these implants have several drawbacks, including long surgical times, discomfort, infection risk, and the potential need for a second surgery for removal. This study proposes an alternative solution using a biodegradable material, poly (lactic-co-glycolic acid) (PLGA), which was fabricated into fibers via electrospinning and braided into threads. These threads were combined with ketorolac, a pain reliever, and teicoplanin, an antibiotic. Mechanical testing showed that pure PLGA had the highest strength, while drug-loaded PLGA still demonstrated acceptable performance. Fatigue tests indicated good resistance to repeated motion, such as breathing. Surface characterization confirmed smooth fiber formation and contact angle measurements showed increased hydrophilicity after drug loading. Drug release tests demonstrated sustained release over time. In-vitro drug release studies (n = 3 per drug) are still in progress and will be validated by HPLC analysis to check the release behaviour. This study suggests that PLGA-based braided structures offer a promising, safer, and multifunctional alternative to metal implants for rib fracture stabilization.
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Fraktur tulang rusuk adalah cedera umum yang dapat menyebabkan komplikasi serius seperti pneumotoraks dan infeksi. Metode perawatan yang sering digunakan adalah Stabilisasi Bedah Fraktur Tulang Rusuk dengan pelat logam; namun, implan ini memiliki beberapa kelemahan, termasuk waktu operasi yang lama, rasa tidak nyaman, risiko infeksi, dan kemungkinan perlu operasi kedua untuk pengangkatan pelat logam. Studi ini menawarkan solusi alternatif dengan menggunakan bahan biodegradable, yaitu poly (lactic-co-glycolic acid) (PLGA), dalam bentuk serat melalui elektrospinning dan dianyam menjadi benang. Benang ini dikombinasikan dengan ketorolac sebagai pereda nyeri dan teicoplanin sebagai antibiotik. Pengujian mekanis menunjukkan bahwa PLGA murni memiliki kekuatan tertinggi, sedangkan PLGA + obat masih menunjukkan kinerja yang memadai. Uji kelelahan menunjukkan ketahanan yang baik terhadap gerakan berulang, seperti pernapasan. Karakterisasi permukaan mengonfirmasi pembentukan serat yang halus, dan pengukuran sudut kontak menunjukkan peningkatan hidrofilisitas setelah pemuatan obat. Uji pelepasan obat menunjukkan pelepasan berkelanjutan seiring waktu. Studi pelepasan obat in vitro (n = 3 per obat) masih berlangsung dan akan divalidasi dengan analisis HPLC untuk memeriksa perilaku pelepasan.Studi ini menunjukkan bahwa struktur anyaman berbasis PLGA menawarkan alternatif yang menjanjikan, lebih aman, dan multifungsi dibandingkan implan logam untuk stabilisasi fraktur tulang rusuk.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	PLGA, Electrospinning, Biodegradable Implants, Rib Fracture, Sustained Drug Release, Elektrospinning, Implan Biodegradable, Fraktur Tulang Rusuk, Pelepasan Obat Berkelanjutan.
Subjects:	Q Science > QP Physiology > QP801.B69 Biopolymers Q Science > QP Physiology > QP801.P64 Polymers--Biodegradation R Medicine > R Medicine (General) > R857.M3 Biomedical materials. Biomedical materials--Testing. R Medicine > RD Surgery > RD755.5.C35 Orthopedic implants. T Technology > T Technology (General) > TA404 Materials--Biodegradation T Technology > TA Engineering (General). Civil engineering (General) > TA418.9.F5 Electrospinning. Nanofibers
Divisions:	Faculty of Industrial Technology and Systems Engineering (INDSYS) > Mechanical Engineering > 21201-(S1) Undergraduate Thesis
Depositing User:	Ulfia Nur Amallia
Date Deposited:	05 Aug 2025 01:19
Last Modified:	07 Aug 2025 07:16
URI:	http://repository.its.ac.id/id/eprint/127316

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