Evaluasi Nilai Geud Berdasarkan Variasi Parameter \alpha Dengan Teknik 3d-Crt Untuk Organ Beresiko Pada Kasus Kanker Serviks

Alfianti, Diah Ayu (2025) Evaluasi Nilai Geud Berdasarkan Variasi Parameter \alpha Dengan Teknik 3d-Crt Untuk Organ Beresiko Pada Kasus Kanker Serviks. Other thesis, Institut Teknologi Sepuluh Nopember Surabaya.

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Abstract

Kanker serviks merupakan salah satu penyebab kematian tertinggi pada perempuan di Indonesia. Teknik 3D-Conformal Radiation Therapy (3D-CRT) masih banyak digunakan karena efisiensi alat dan biaya, meskipun memiliki tantangan dalam distribusi dosis yang optimal, terutama dalam melindungi organ di sekitar target (OAR). Penelitian ini menganalisis pengaruh variasi parameter α dalam perhitungan generalized Equivalent Uniform Dose (gEUD) terhadap nilai risiko komplikasi jaringan normal (NTCP) pada rektum, kandung kemih, dan usus besar. Evaluasi dilakukan menggunakan tiga variasi plan 3D-CRT, yaitu tanpa optimasi, optimasi Field-in-Field (FiF), dan optimasi Multi-Leaf Collimator (MLC), dengan α bervariasi dari -5 hingga 40 menggunakan model NTCP Lyman. Hasil menunjukkan bahwa gEUD dan NTCP meningkat seiring kenaikan α, dengan lonjakan paling tajam pada α = -5 hingga 5. Plan tanpa optimasi menghasilkan NTCP tertinggi, sedangkan optimasi MLC paling rendah secara konsisten. Seluruh plan masih dalam batas aman untuk rektum dan kandung kemih, namun untuk usus besar hanya plan MLC dan FiF yang lolos hingga α = 20. Nilai α yang direkomendasikan untuk evaluasi OAR adalah -5 ≤ α ≤ 1 karena memberikan hasil yang lebih stabil dan representatif. Optimasi MLC direkomendasikan karena paling efektif dalam menurunkan risiko komplikasi pada jaringan sehat.
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Cervical cancer is one of the leading causes of death among women in Indonesia. The 3D-Conformal Radiation Therapy (3D-CRT) technique remains widely used owing to its equipment efficiency and cost-effectiveness, although it presents challenges in achieving optimal dose distribution, particularly in sparing organs at risk (OAR) surrounding the target. This study analyzed the effect of varying the α parameter in the generalized Equivalent Uniform Dose (gEUD) calculation on the risk of normal tissue complications (NTCP) in the rectum, bladder, and large intestine. Evaluation was conducted using three 3D-CRT planning variations: non-optimized, field-in-field (FiF) optimization, and Multi-Leaf Collimator (MLC) optimization, with α values ranging from -5 to 40 based on the Lyman NTCP model. The results show that the gEUD and NTCP values increase with higher α, with the steepest rise observed between α = -5 and 5. The nonoptimized plan yielded the highest NTCP, whereas MLC optimization consistently produced the lowest values. All plans remained within the clinical safety thresholds for the rectum and bladder; however, for the large intestine, only the MLC and FiF plans remained within safe limits up to α = 20. The recommended α range for evaluating OAR is -5 ≤ α ≤ 1, as it provides more stable and representative dose distribution. MLC optimization is recommended as the most effective method for minimizing the risk of complications in healthy tissues.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	cervical cancer, 3D-CRT, gEUD, NTCP, alpha parameters, organ at risk, kanker serviks, 3D-CRT, gEUD, NTCP, parameter alpha, OAR.
Subjects:	Q Science Q Science > QC Physics Q Science > QC Physics > QC795.5 Radioactivity and radioactive Instruments and apparatus (General)
Divisions:	Faculty of Science and Data Analytics (SCIENTICS) > Physics > 45201-(S1) Undergraduate Thesis
Depositing User:	Diah Ayu Alfianti
Date Deposited:	05 Aug 2025 07:20
Last Modified:	05 Aug 2025 07:20
URI:	http://repository.its.ac.id/id/eprint/127524

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