Sintesis 3-Prenil-5,5-Difenilimidazolidin-2,4-Dion

Wirastuti, Vania (2022) Sintesis 3-Prenil-5,5-Difenilimidazolidin-2,4-Dion. Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Imidazola 1 merupakan senyawa yang dikembangkan secara luas karena memiliki aktivitas biologis yang beragam seperti antikanker, antimikroba, antiulkus, inhibitor spesifik enzim, antihipertensi, antiinflamasi, agen analgesik, dan agen anestesi. Turunan imidazola 1 berupa 5,5-difenilimidazolidin-2,4-dion 29 telah diaplikasikan untuk menangani penyakit epilepsi. Alkilasi, arilasi, dan halogenasi pada posisi N1, N3, dan C5 telah digunakan dalam modifikasi struktur 5,5-difenilimidazolidin-2,4-dion 29. Gugus prenil diketahui mempengaruhi aktivitas biologi suatu senyawa. Penelitian yang dilakukan bertujuan untuk mendapatkan 3-prenil-5,5-difenilimidazolidin-2,4-dion 42 melalui modifikasi 5,5-difenilimidazolidin-2,4-dion 29 dengan penambahan gugus prenil. Metode penelitian dilakukan melalui sintesis 2-hidroksi-1,2-di(fenil)etanona 46, 1,2-di(fenil)etan-1,2-dion 45, 5,5-difenilimidazolidin-2,4-dion 29, dan 3-prenil-5,5-difenilimidazolidin-2,4-dion 42. Penelitian telah berhasil mendapatkan 2-hidroksi-1,2-di(fenil)etanona 46 dengan rendemen sebesar 60%, 1,2-di(fenil)etan-1,2-dion 45 dengan rendemen sebesar 79%, 5,5-difenilimidazolidin-2,4-dion 29 dengan rendemen sebesar 23%, dan 3-prenil 5,5-difenilimidazolidin-2,4-dion 42 dengan rendemen sebesar 26%.
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Imidazole 1 is a compound that has been widely developed because of its various biological activities such as anticancer, antimicrobial, antiulcer, enzyme-specific inhibitor, antihypertensive, anti-inflammatory, analgesic agent, and anesthetic agent. Imidazole derivative 1, 5,5-diphenimidazolidine-2,4-dione 29 has been applied to treat epilepsy. Alkylation, arylation, and halogenation at the N1, N3, and C5 positions have been used in the modification of the structure of 5,5-diphenimidazolidine-2,4-dione 29. Prenyl groups are known to affect the biological activity of a compound. The aim of the research was to obtain 3-prenyl-5,5-diphenimidazolidine-2,4-dione 42 by modifying 5,5-diphenimidazolidin-2,4-dione 29 with the addition of a prenyl group. The research method was carried out through the synthesis of 2-hydroxy-1,2-di(phenyl)ethanone 46, 1,2-di(phenyl)ethane-1,2-dione 45, 5,5-diphenylimidazolidine-2,4-dione 29, and 3-prenyl-5,5-diphenylimidazolidine-2,4-dione 42. Research has succeeded in obtaining 2-hydroxy-1,2-di(phenyl)ethanone 46 with a yield of 60%, 1,2-di(phenyl)ethane-1,2-dione 45 with a yield of 79%, 5,5-diphenylimidazolidine-2,4-dione 29 with a yield of 23%, and 3-prenyl 5,5-diphenylimidazolidine-2,4-dione 42 with a yield of 26%.

Item Type:	Thesis (Other)
Additional Information:	Sintetis 3-prenil-5,5-difenilimidazolidin-2,4-dion RSKi 541.39 Wir s-1
Uncontrolled Keywords:	imidazola, 5,5-difenilimidazolidin-2,4-dion, prenilasi. imidazole, 5,5-diphenylimidazolidine-2,4-dione, prenylation.
Subjects:	T Technology > TP Chemical technology > TP159.A5 Antioxidants
Divisions:	Faculty of Science and Data Analytics (SCIENTICS) > Chemistry > 47201-(S1) Undergraduate Thesis
Depositing User:	Mr. Marsudiyana -
Date Deposited:	05 May 2026 06:39
Last Modified:	05 May 2026 06:39
URI:	http://repository.its.ac.id/id/eprint/132992

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