Desain Pabrik Garam Farmasi Dari Garam Rakyat Dengan Mechanical Vapor Recompression (MVR) Dan Kristalisasi

Azaliyah, Adine Nur and Larasati, Zefania Jasmin (2026) Desain Pabrik Garam Farmasi Dari Garam Rakyat Dengan Mechanical Vapor Recompression (MVR) Dan Kristalisasi. Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Garam farmasi merupakan garam yang memiliki kemurnian NaCl > 99%. Pemanfaatan dari garam farmasi digunakan sebagai bahan baku penyedia infus, produksi tablet, pelarut vaksin, sirup, oralit, cairan pencuci darah, dan lain-lain. Berdasarkan data dari BPS tahun 2024, keperluan garam di Indonesia selalu mengalami kenaikan serta pemasok garam farmasi sebagian besar berasal dari hasil impor. Pembangunan garam farmasi diharapkan dapat memenuhi kebutuhan garam farmasi di Indonesia. Bahan baku produksi garam farmasi adalah garam yang didapatkan dari petani tambak garam di Indramayu. Metode yang digunakan untuk proses produksi diseleksi menggunakan metode AHP dan metode yang dipilih adalah
metode kristalisasi dan mechanical vapor recompression (MVR) dengan pre-treatment menggunakan penambahan chemical treatment NaOH dan Na2CO3 dan membran nanofiltrasi. Pabrik Garam Farmasi ini akan dibangun di Indramayu, Jawa
Barat berdekatan dengan sumber bahan baku. Proses produksi dimulai dengan proses pemurnian menggunakan larutan Na2CO3 dan NaOH sehingga menghasilkan endapan CaCO3, Mg(OH)2 dan larutan Na2SO4. Endapan CaCO3 dan Mg(OH)2 dapat dipisahkan dari larutan garam menggunakan centrifuge. Dilanjutkan dengan proses pemisahan ion sulfat yang ada di larutan Na2SO4 dan CaSO4 dengan membran nanofiltrasi sehingga larutan garam dapat memenuhi standar Farmakope Indonesia.
Kemudian, larutan dialirkan ke dalam reaktor kristalisasi yang dilengkapi oleh Mechanical Vapor Recompression (MVR) untuk meningkatkan kemurniannya. Pabrik garam ini akan beroperasi selama 15 tahun dimana menghasilkan IRR sebesar
12,01%, NPV sebesar Rp11.034.152.631,08 (bernilai positif), dimana pabrik mengalami titik impas ketika beroperasi pada 52,13% kapasitas, dengan pengembalian modal pabrik selama 6,42tahun.
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Pharmaceutical salt is a refined salt product with a purity of more than 99% NaCl. It is widely used as a raw material for infusion solutions, tablet production, vaccine solvents, syrups, oral rehydration salts (ORS), dialysis fluids, and other pharmaceutical applications. According to Statistics Indonesia (BPS, 2024), the demand for salt in Indonesia continues to increase every year, while the majority of pharmaceutical-grade salt is still imported. Therefore, the
establishment of a domestic pharmaceutical salt production plant is expected to reduce import dependency and fulfill national needs. The raw material used in this study is salt produced by local salt farmers in Indramayu. The production method was selected using the Analytical Hierarchy Process (AHP), and the chosen process consists of chemical pre-treatment, nanofiltration, crystallization, and Mechanical Vapor Recompression (MVR). The plant will be built in Indramayu, West Java, close to the source of raw materials. The production process begins with chemical pretreatment using Na₂CO₃ and NaOH solutions to remove impurities, resulting in the formation of CaCO₃ and Mg(OH)₂ precipitates and a Na₂SO₄-rich brine solution. The precipitates of CaCO₃ and Mg(OH)₂ are then separated from the brine using a centrifuge. Subsequently, the remaining sulfate ions (SO₄²⁻) originating from Na₂SO₄ and CaSO₄ are separated through a nanofiltration membrane, so that the purified brine meets the quality requirements of the Indonesian Pharmacopoeia. The purified solution is then fed into a crystallizer equipped with a Mechanical Vapor Recompression (MVR) system to enhance the purity of the salt product. The salt plant is planned to operate for 15 years, generating an Internal
Rate of Return (IRR) of 12.01% and a positive Net Present Value (NPV) of IDR 11,034,152,631.08. The plant reaches its break-even point at 52.13% of its production capacity,with a payback period of 6.42 years.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	Pharmaceutical Salt, Crude Salt, Crystallization, Mechanical Vapor Recompression, Garam Farmasi, Garam Rakyat, Kristalisasi, Kompresi Ulang Secara Mekanik
Subjects:	T Technology > TP Chemical technology > TP155.5 Chemical plants--Design and construction T Technology > TP Chemical technology > TP155.7 Chemical processes. T Technology > TP Chemical technology > TP156 Crystallization. Extraction (Chemistry). Fermentation. Distillation. Emulsions.
Divisions:	Faculty of Industrial Technology and Systems Engineering (INDSYS) > Chemical Engineering > 24201-(S1) Undergraduate Thesis
Depositing User:	Adine Nur Azaliyah
Date Deposited:	20 Jul 2026 03:17
Last Modified:	22 Jul 2026 04:56
URI:	http://repository.its.ac.id/id/eprint/135631

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