Iskandar, Farhan Atha (2026) Pengaruh Variasi Konsentrasi Strontium Dan Temperatur Kalsinasi Terhadap Karakteristik Borate Based Bioactive Glass Menggunakan Metode Spray Drying Untuk Aplikasi Bone Filler. Other thesis, Institut Teknologu Sepuluh Nopember.
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Abstract
Kerusakan jaringan tulang yang disebabkan oleh trauma, infeksi, reseksi tumor, maupun kondisi degeneratif membutuhkan material biomaterial yang dapat menunjang proses regenerasi tulang secara optimal. Borate-based bioactive glass merupakan salah satu kandidat material pengisi tulang karena memiliki bioaktivitas tinggi, laju degradasi relatif cepat, serta kemampuan melepaskan ion yang dapat mendukung proses osteogenesis. Namun, laju degradasi yang terlalu cepat perlu dikontrol melalui rekayasa komposisi dan perlakuan panas. Penelitian ini dilakukan untuk mengkaji pengaruh variasi kadar strontium dan temperatur kalsinasi terhadap karakteristik borate-based bioactive glass terhadap karakteristik borate-based bioactive glass yang disintesis menggunakan metode spray drying untuk aplikasi bone filler. Komposisi dasar material menggunakan sistem Ca:P:B, dengan variasi konsentrasi strontium sebesar 5 mol%, 10 mol%, dan 15 mol%, dengan variasi temperatur kalsinasi yang meliputi 500°C, 600°C, dan 700°C. Sampel hasil sintesis dilakukan pengujian karakterisasi menggunakan X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), dan Energy Dispersive X-Ray Spectroscopy (EDX). Hasil pengujian XRD mengindikasikan bahwa sampel yang dikalsinasi pada suhu 500°C dan 600°C masih menunjukkan fase amorf, sedangkan kalsinasi pada temperatur 700°C menyebabkan munculnya puncak-puncak kristalin yang mengindikasikan terjadinya kristalisasi parsial. Fase kristalin yang terindikasi meliputi Ca₄(PO₄)₂O, Ca₂B₂O₅, CaO, SrCO₃, dan B₂O₃. Hasil SEM menunjukkan bahwa partikel yang dihasilkan memiliki morfologi dominan semi-sferis, permukaan kasar, sebagian cekung, serta mengalami aglomerasi. Peningkatan konsentrasi strontium dan temperatur kalsinasi cenderung meningkatkan kekasaran permukaan, aglomerasi, dan densifikasi partikel. Hasil EDX mengonfirmasi keberadaan unsur B, O, Sr, P, dan Ca pada sampel, serta menunjukkan bahwa strontium berhasil terdeteksi dalam sistem bioactive glass. Berdasarkan keseluruhan hasil karakterisasi, temperatur kalsinasi 600°C, khususnya pada komposisi Sr 10 mol%, menunjukkan kondisi yang seimbang karena masih mempertahankan karakter amorf, memiliki morfologi partikel yang stabil, dan menunjukkan keberadaan Sr. Borate-based bioactive glass dopan strontium hasil metode spray drying berpotensi dikembangkan sebagai biomaterial untuk aplikasi bone filler.
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Bone defects resulting from trauma, infection, tumor resection, and degenerative diseases require biomaterials capable of effectively supporting bone regeneration.. Borate-based bioactive glass is considered a promising candidate for bone filler applications due to its excellent bioactivity, relatively fast degradation behavior, and ability to release therapeutic ions that support osteogenic activity. Nevertheless, its rapid degradation rate must be regulated through compositional modification and thermal processing.This study investigates the influence of strontium content and calcination temperature on the properties of borate-based bioactive glass synthesized via the spray drying technique for bone filler applications. The base composition system consisted of Ca:P:B, with strontium additions of 5 mol%, 10 mol%, and 15 mol%, and calcination temperatures set at 500°C, 600°C, and 700°C. The obtained samples were characterized using X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and Energy Dispersive X-Ray Spectroscopy (EDX).XRD analysis revealed that samples treated at 500°C and 600°C mainly exhibited an amorphous structure, while samples calcined at 700°C showed the emergence of crystalline peaks, indicating partial crystallization. The detected crystalline phases included Ca₄(PO₄)₂O, Ca₂B₂O₅, CaO, SrCO₃, and B₂O₃. SEM observations indicated that the particles predominantly had a semi-spherical shape with rough surfaces, partially concave morphology, and noticeable agglomeration. An increase in strontium content and calcination temperature was found to enhance surface roughness, particle agglomeration, and densification. EDX results confirmed the presence of B, O, Sr, P, and Ca elements, indicating successful incorporation of strontium into the bioactive glass network. Overall, the sample calcined at 600°C with 10 mol% Sr content exhibited the most balanced properties, as it maintained an amorphous phase, showed stable particle morphology, and confirmed effective strontium incorporation. Therefore, strontium-doped borate-based bioactive glass prepared by spray drying demonstrates strong potential for use as a bone filler biomaterial.
| Item Type: | Thesis (Other) |
|---|---|
| Uncontrolled Keywords: | Bioactive glass, borate-based bioactive glass, strontium, spray drying, bone filler, kalsinasi. Bioactive glass, borate-based bioactive glass, strontium, spray drying, bone filler, calcination. |
| Subjects: | Q Science Q Science > Q Science (General) R Medicine > R Medicine (General) R Medicine > R Medicine (General) > R857.M3 Biomedical materials. Biomedical materials--Testing. |
| Divisions: | Faculty of Industrial Technology and Systems Engineering (INDSYS) > Material & Metallurgical Engineering > 28201-(S1) Undergraduate Thesis |
| Depositing User: | Farhan Atha Iskandar |
| Date Deposited: | 24 Jul 2026 02:34 |
| Last Modified: | 24 Jul 2026 02:34 |
| URI: | http://repository.its.ac.id/id/eprint/136998 |
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