Herliyanah, Yati and Nisa, Aisyah Fazila Noorun (2026) Pengembangan Hidrogel CMC/CS/SA Terimpregnasi Zno dan Ekstrak Tanin dari Piper Crocatum sebagai Agen Antibakteri dan Antioksidan untuk Aplikasi Wound Dressing dengan Metode Ultrasonikasi. Other thesis, Institut Teknologi Sepuluh Nopember.
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Abstract
Keterbatasan wound dressing konvensional dalam menjaga kelembapan luka dan mencegah infeksi mendorong adanya keterbaruan teknologi wound dressing berbasis hidrogel yang lebih fungsional. Penelitian ini bertujuan untuk mengembangkan hidrogel berbasis carboxymethyl cellulose (CMC), chitosan (CS), dan sodium alginate (SA) dengan penambahan nanopartikel zinc oxide (ZnO) dan ekstrak tanin yang bersumber dari daun Piper crocatum sebagai wound dressing multifungsional. Dilakukan penambahan nanopartikel ZnO yang berperan sebagai agen antibakteri anorganik dengan toksisitas rendah, serta penambahan ekstrak tanin yang berfungsi sebagai agen antioksidan dan antibakteri alami. Variabel penelitian meliputi variasi konsentrasi ekstrak tanin sebesar 1%; 2%; 3%; 4%; dan 5%, dengan parameter lainnya dijaga konstan, serta dilakukan karakterisasi untuk mengetahui sifat fisikokimia dan performanya sebagai hydrogel wound dressing. Hasil karakterisasi FTIR menunjukkan pergeseran pita serapan O–H dari 3391 ke 3369 cm⁻¹, mengindikasikan adanya interaksi koordinatif antara ZnO dan matriks hidrogel. Karakterisasi SEM-EDX mengungkapkan morfologi serat padat bertumpuk dan mengonfirmasi keberadaan ZnO dalam matriks melalui deteksi unsur Zn sebesar 1,65%. Penambahan TA meningkatkan kapasitas swelling hingga 291%. Hidrogel 5% TA menunjukkan performa terbaik dengan aktivitas antioksidan 91.07% serta zona hambat terhadap Staphylococcus aureus dan Pseudomonas aeruginosa masing-masing sebesar 12.05 mm dan 10.5 mm.
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The limitations of conventional wound dressings in maintaining wound moisture and preventing infection have driven innovation in more functional hydrogel-based wound dressing technology. This research aims to develop a hydrogel based on carboxymethyl cellulose (CMC), chitosan (CS), and sodium alginate (SA) with the addition of zinc oxide (ZnO) nanoparticles and tannin extract derived from Piper crocatum leaves as a multifunctional wound dressing. The combination of these three biopolymers is anticipated to produce a hydrogel matrix capable of maintaining wound moisture while providing good structural stability. ZnO nanoparticles are added as an inorganic antibacterial agent with low toxicity, along with tannin extract which functions as a natural antioxidant and antibacterial agent. Research variables include variations in tannin extract concentrations of 1%, 2%, 3%, 4%, and 5%, with all other parameters held constant, followed by characterization to evaluate the physicochemical properties and performance. FTIR characterization revealed a shift in the O–H absorption band from 3391 to 3369 cm⁻¹, indicating a coordinative interaction between ZnO and the hydrogel matrix. SEM-EDX analysis revealed a stacked solid fiber morphology and confirmed the presence of ZnO within the matrix through the detection of Zn at 1.65%. The addition of tannin extract increased the swelling capacity up to 291%. The hydrogel containing 5% tannin extract demonstrated the best overall performance, with an antioxidant activity of 91.07% and inhibition zones against Staphylococcus aureus and Pseudomonas aeruginosa of 12.05 mm and 10.5 mm, respectively, establishing it as the optimum concentration in this study.
| Item Type: | Thesis (Other) |
|---|---|
| Uncontrolled Keywords: | Hydrogel, Piper crocatum, Tannin Extract, Ultrasonikasi, Wound dressing, Ultrasonication |
| Subjects: | R Medicine > R Medicine (General) > R857.M3 Biomedical materials. Biomedical materials--Testing. T Technology > TA Engineering (General). Civil engineering (General) > TA418.9 Composite materials. Laminated materials. T Technology > TP Chemical technology > TP1140 Polymers T Technology > TP Chemical technology > TP159.A5 Antioxidants T Technology > TP Chemical technology > TP248 Nanogels. Nanoparticles. |
| Divisions: | Faculty of Vocational > 24305-Industrial Chemical Engineering |
| Depositing User: | Yati Herliyanah |
| Date Deposited: | 24 Jul 2026 13:51 |
| Last Modified: | 24 Jul 2026 13:51 |
| URI: | http://repository.its.ac.id/id/eprint/137463 |
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