Pemodelan Aliran Darah Casson Pada Branch Retinal Vein Occlusion (BRVO) Dengan Elastic Effects

Verliana, Verliana (2026) Pemodelan Aliran Darah Casson Pada Branch Retinal Vein Occlusion (BRVO) Dengan Elastic Effects. Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Oklusi Vena Retina (Retinal Vein Occlusion) merupakan gangguan vaskular pada mata yang dapat menyebabkan kebutaan permanen akibat terganggunya hemodinamik aliran darah. Penelitian terdahulu memodelkan penyempitan pembuluh darah (stenosis) dengan asumsi geometri simetris dan dinding kaku, padahal kondisi patologis klinis seringkali menunjukkan bentuk stenosis yang asimetris dan dinding vena yang bersifat elastis (compliant). Penelitian Tugas Akhir ini bertujuan untuk menganalisis karakteristik aliran darah pada vena retina cabang yang mengalami stenosis asimetris dengan memperhitungkan sifat Non-Newtonian darah dan efek elastisitas dinding pembuluh. Darah dimodelkan sebagai fluida incompressible Non-Newtonian menggunakan model konstitutif Casson untuk mengakomodasi perilaku yield stress pada laju geser rendah. Persamaan pengatur yang terdiri dari persamaan kontinuitas dan momentum diselesaikan secara numerik menggunakan Finite Volume Method (FVM). Algoritma SIMPLER diimplementasikan dalam perangkat lunak MATLAB untuk menangani kopel tekanan-kecepatan. Simulasi dilakukan dengan memvariasikan tingkat keparahan stenosis dan parameter elastisitas dinding. Hasil simulasi numerik dengan sifat Non-Newtonian Casson diharapkan menunjukkan bahwa geometri stenosis asimetris menyebabkan perubahan signifikan pada pola aliran, termasuk pembentukan zona resirkulasi yang lebih besar di bagian hilir penyempitan dibandingkan geometri simetris. Selain itu, efek elastisitas dinding diharapkan menunjukkan adanya perbedaan fluktuasi tekanan dan perubahan distribusi kecepatan di sekitar area stenosis. Penelitian ini diharapkan memberikan wawasan matematis baru mengenai faktor risiko biomekanik yang berkontribusi terhadap perkembangan BRVO.
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Retinal vein occlusion is a vascular disorder of the eye that can cause permanent blindness due to impaired hemodynamics of blood flow. Previous studies have modeled blood vessel narrowing (stenosis) assuming symmetric geometry and rigid walls, whereas clinical pathological conditions often exhibit asymmetric stenosis and elastic (compliant) vein walls. This final project aims to analyze the blood flow characteristics of branch retinal veins experiencing asymmetric stenosis by considering the non-Newtonian properties of blood and the effects of vessel wall elasticity. Blood is modeled as an incompressible non-Newtonian fluid using the Casson constitutive model to accommodate the yield stress behavior at low shear rates. The governing equations, consisting of continuity and momentum equations, are solved numerically using the Finite Volume Method (FVM). The SIMPLER algorithm is implemented in MATLAB software to handle pressure-velocity coupling. Simulations were performed by varying the severity of stenosis and wall elasticity parameters. Numerical simulation results using the non-Newtonian Casson properties are expected to demonstrate that asymmetric stenosis geometry causes significant changes in flow patterns, including the formation of a larger recirculation zone downstream of the narrowing compared to symmetric geometry. Furthermore, the effect of wall elasticity is expected to demonstrate differences in pressure fluctuations and changes in velocity distribution around the stenosis area. This study is expected to provide new mathematical insights into the biomechanical risk factors contributing to the development of BRVO.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	Efek Elastis, Metode Volume Hingga, Fluida Casson, Hemodinamika, Oklusi Vena Retina Cabang, Elastic Effects, Finite Volume Method, Casson Fluid, Hemodynamics, Branch Retinal Vein Occlusion
Subjects:	Q Science > QA Mathematics > QA371 Differential equations--Numerical solutions Q Science > QA Mathematics > QA401 Mathematical models. Q Science > QA Mathematics > QA640.7 Discrete geometry Q Science > QA Mathematics > QA911 Fluid dynamics. Hydrodynamics
Divisions:	Faculty of Science and Data Analytics (SCIENTICS) > Mathematics > 44201-(S1) Undergraduate Thesis
Depositing User:	Verliana Verliana
Date Deposited:	29 Jul 2026 06:28
Last Modified:	29 Jul 2026 06:28
URI:	http://repository.its.ac.id/id/eprint/139486

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