Pengaruh Komposisi Pati, Pektin, dan Kitosan terhadap Karakteristik Film Mukoadhesif sebagai Sistem Penghantar Obat Lokal untuk Gingivitis

Afifah, Arina Nur (2026) Pengaruh Komposisi Pati, Pektin, dan Kitosan terhadap Karakteristik Film Mukoadhesif sebagai Sistem Penghantar Obat Lokal untuk Gingivitis. Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Gingivitis merupakan tahap awal penyakit periodontal yang umumnya ditangani dengan terapi lokal seperti obat kumur dan gel topikal, namun waktu kontaknya yang singkat pada rongga mulut membuat efektivitas terapi kurang optimal. Penelitian ini mengembangkan film mukoadhesif berbasis pati tapioka, pektin, dan kitosan yang diinkorporasi tetracycline 0,7% sebagai sistem penghantaran obat lokal terkontrol untuk terapi gingivitis, dibuat dengan metode solvent casting pada variasi rasio pati:pektin (80:20, 70:30, 60:40) dan konsentrasi kitosan (0,5%, 1%, 1,5%). Karakterisasi meliputi ketebalan, sifat mekanik (tensile strength dan elongation at break), swelling, gugus fungsi (FTIR), serta profil pelepasan obat in vitro menggunakan spektrofotometri UV-Vis dalam media saliva buatan. Peningkatan konsentrasi kitosan terbukti meningkatkan kekuatan tarik film tertinggi 37,04 MPa pada formula AK151 (pati:pektin 80:20, kitosan 1,5%), namun menurunkan elongasi dan swelling akibat matriks yang semakin rapat, dengan nilai swelling index tertinggi 47,17% pada CK051. Formula BK101 (pati:pektin 70:30, kitosan 1%) terpilih sebagai formula paling optimal dengan ketebalan 0,080 ± 0,0067 mm, swelling index 24,05%, dan profil pelepasan tetracycline terkontrol (sustained release), yaitu laju pelepasan menurun dari 0,0109%/jam pada pengamatan 4 jam pertama menjadi 0,0020%/jam pada pengamatan hari ke-6, menunjukkan keseimbangan terbaik antara kekuatan mekanik, kemampuan hidrasi, dan pengendalian pelepasan obat. Penelitian ini berkontribusi terhadap SDG 3 (Good Health and Well-being) melalui pengembangan sistem terapi lokal kesehatan mulut, serta SDG 12 (Responsible Consumption and Production) melalui pemanfaatan biopolimer alami yang ramah lingkungan.
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Gingivitis is an early stage of periodontal disease that is generally treated with local therapies such as mouthwashes and topical gels; however, their short contact time in the oral cavity makes therapeutic effectiveness suboptimal. This study developed a mucoadhesive film based on tapioca starch, pectin, and chitosan incorporated with 0.7% tetracycline as a controlled local drug delivery system for gingivitis therapy, prepared using the solvent casting method with variations in starch:pectin ratio (80:20, 70:30, 60:40) and chitosan concentration (0.5%, 1%, 1.5%). Characterization included thickness, mechanical properties (tensile strength and elongation at break), swelling, functional groups (FTIR), and in vitro drug release profile using UV-Vis spectrophotometry in artificial saliva medium. Increasing chitosan concentration was shown to increase the film's tensile strength the highest being 37.04 MPa in formula AK151 (starch:pectin 80:20, chitosan 1.5%), but decreased elongation and swelling due to an increasingly dense matrix, with the highest swelling index value of 47.17% found in CK051. Formula BK101 (starch:pectin 70:30, chitosan 1%) was selected as the most optimal formula, with a thickness of 0.080 ± 0.0067 mm, a swelling index of 24.05%, and a controlled (sustained release) tetracycline release profile. Namely, a release rate decreasing from 0.0109%/hour during the first 4 hours of observation to 0.0020%/hour by day 6 of observation, demonstrating the best balance between mechanical strength, hydration capacity, and control of drug release. This research contributes to SDG 3 (Good Health and Well-being) through the development of a local oral health therapy system, as well as SDG 12 (Responsible Consumption and Production) through the utilization of environmentally friendly natural biopolymers.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	Film mukoadhesif, Kitosan, Pati tapioka, Pektin, SDG 3, SDG 12, Tetracycline, Chitosan, Drug release, Mucoadhesive film, Pectin, Tapioca starch.
Subjects:	R Medicine > R Medicine (General) T Technology > T Technology (General) T Technology > T Technology (General) > TA404 Materials--Biodegradation
Divisions:	Faculty of Industrial Technology and Systems Engineering (INDSYS) > Physics Engineering > 30201-(S1) Undergraduate Thesis
Depositing User:	Arina Nur Afifah
Date Deposited:	15 Sep 2026 00:49
Last Modified:	15 Sep 2026 01:10
URI:	http://repository.its.ac.id/id/eprint/143947

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