Uji Antimalaria Senyawa GB-1a Dan Morelloflavon Dari Kayu Batang Garcia xanthochymus (Buran)

Sari, Winta Wulan (2009) Uji Antimalaria Senyawa GB-1a Dan Morelloflavon Dari Kayu Batang Garcia xanthochymus (Buran). Masters thesis, Institut Teknologi Sepuluh November.

Text 1407201739-Master_thesis.pdf Restricted to Repository staff only Download (10MB)

Abstract

Dua senyawa biflavonoid, GB-la (1) dan morelloflavon (2) telah diisolasi dari ekstrak metanol kayu batang Garcinia xanthochymus, tanaman koleksi Kebun Raya Bogor, Jawa Barat. Kedua senyawa tersebut dipisahkan dengan metode ekstraksi maserasi kemudian dilanjutkan fraksinasi dengan kromatografi cair vakum (KCV) dan pemurnian dengan kromatografi lapis tipis preparatif (KLTp). Struktur molekul senyawa dilakukan berdasarkan data spektroskopi UV, IR, ¹H dan ¹³C NMR. Selanjutnya hasil uji aktivitas antimalaria menggunakan parasit Plasmodium falciparum strain 3D7 menunjukkan bahwa senyawa 2 lebih aktif dibandingkan senyawa 1 dengan IC50 0,01 pg/ml dan 0,34 pg/ml.
======================================================================================================================================
Two biflavonoid compounds, GB-la (1) and morelloflavon (2) have been isolated from methanol extract of wood Garcinia xanthochymus that collected in Kebun Raya Bogor, West Java. Both of them were isolated using extraction method by maceration and then fractination by vacuum column chromathography (KCV) and purified by preparative thin layer chromatography (KLTp). The structure has been elucidated with the aid of physical data and spectroscopic techniques UV, IR, ¹H and ¹³C NMR. Compounds 2 was more potent antimalarial activity against Plasmodium falciparum 3D7 strain than compound 1 with IC50 values of 0,01 pg/ml and 0,34 pg/ml.

Item Type:	Thesis (Masters)
Additional Information:	583.624 Sar u
Uncontrolled Keywords:	Garcinia xanthochymus, antimalaria, biflavonoid, Plasmodium falciparum
Subjects:	Q Science > QD Chemistry > QD251.2 Chemistry, Organic. Biochemistry
Divisions:	Faculty of Mathematics and Science > Chemistry > 47101-(S2) Master Thesis
Depositing User:	magang .
Date Deposited:	02 Oct 2026 08:31
Last Modified:	02 Oct 2026 08:31
URI:	http://repository.its.ac.id/id/eprint/145215

Actions (login required)

View Item