Millisa, . (2017) Potensi Produk Deasetilasi Enzimatik Kitin Sebagai Drug carrier Asetaminofen Pada Mencit (Mus musculus L.) Albino Swiss Webster Jantan. Undergraduate thesis, Institut Teknologi Sepuluh Nopember.
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Abstract
Fabrikasi dan formulasi terhadap sediaan farmasi saat ini terus dikembangkan, Hal ini disebabkan efektifitas dan bioavailibitas obat yang rendah, oleh karena itu diperlukan penggunaan drug carrier agar dapat meningkatkan bioavailibitas obat, mengurangi efek samping dan mengurangi limbah obat. Kitosan merupakan salah satu biopolimer yang berpotensi sebagai drug carrier karena bersifat kationik sehingga dapat berinteraksi dengan senyawa anionik melalui ikatan taut silang (cross linking). Penelitian ini bertujuan untuk mendapatkan mikrosfer obat dengan menggunakan kitosan hasil deasetilasi enzimatik kitin sebagai drug carrier asetaminofen pada Mus musculus L. Swiss Webster jantan yang dilakukan secara in vivo.
Hasil fabrikasi mikrosfer berbentuk padatan dan berwarna kuning kecoklatan, jumlah obat setiap mg mikrosfer 1:1 dan 1:2 yaitu 0,007 mg dan 0,0125 mg, Efisiensi enkapsulasi yaitu 0,7% dan 1,25 %. serta Persentase asetaminofen pada urin yaitu kontrol 0,5%, Mikrosfer 1:1 6,4% dan mikrosfer 1:2 19%.
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Fabrication and formulation of pharmaceutical preparations are currently being developed, this is due to the low effectiveness and bioavailability of the drug. The usage of drug carriers therefore is a major factor in improving the bioavailability, reducing side effects and reducing drug waste. Chitosan is one of the potential biopolymers as a drug carrier because its cationic character could interact with anionic compounds through crosslinking links. The objective of this study is to create a drug microspheres by using chitosan from enzymatic chitin deacetylation product as the drug carrier of acetaminophen in male Mus musculus L. Swiss Webster which will be carried out under in vivo process.
Microsphere was fabricated as a yellow-brownish solid, the amount of acetaminophen per mg microsphere 1:1 and 1:2 was 0,007 mg and 0,0125 mg. Encapsulation efficiency was 0,7% and 1,25%. Acetaminophen percentage of urine was control 0,5%, Microsphere 1:1 6,4% and microsphere 1:2 19%.
| Item Type: | Thesis (Undergraduate) |
|---|---|
| Uncontrolled Keywords: | Asetaminofen, Drug Carrier, Kitosan, Mus musculus L. Swiss Webster. |
| Subjects: | Q Science > QL Zoology Q Science > QR Microbiology |
| Divisions: | Faculty of Mathematics and Science > Biology > 46201-(S1) Undergraduate Thesis |
| Depositing User: | Millisa Millisa |
| Date Deposited: | 03 Jan 2018 04:32 |
| Last Modified: | 06 Mar 2019 02:10 |
| URI: | http://repository.its.ac.id/id/eprint/47564 |
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