Sintesis 1,4-Di-(Indol-3-Karbaldehida-1-Ilmetil)Benzena dan 1,4-Di-(Indol-3-Hidroksimetil-1-Ilmetil)Benzena

Anam, Ahmad Mudzakkirul (2017) Sintesis 1,4-Di-(Indol-3-Karbaldehida-1-Ilmetil)Benzena dan 1,4-Di-(Indol-3-Hidroksimetil-1-Ilmetil)Benzena. Undergraduate thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Senyawa heterosiklik yang mengandung atom nitrogen merupakan senyawa penting dalam bidang kimia obat, diantaranya adalah indol dan turunannya yang dilaporkan mempunyai bioaktivitas anti-kanker. Sehubungan dengan hasil studi literatur maka dapat dibuat hipotesa bahwa 1,4-di-(indol-3-karbaldehida-1-ilmetil)benzena dan 1,4-di-(indol-3-hidroksimetil-1-ilmetil)benzena lebih mempunyai aktivitas anti-kanker. Penelitian yang dilakukan berhasil mensintesis indol-3-karboksaldehida dan natrium hidrida dalam asetonitril diperoleh 1,4-di-(indol-3-karbaldehida-1-ilmetil)benzena dengan rendemen 99%. Reduksi 1,4-di-(indol-3-karbaldehida-1-ilmetil)benzena dengan natrium borohidrida dalam etanol diperoleh 1,4-di-(indol-3-hidroksimetil-1-ilmetil)benzena dengan rendemen 80%. Struktur senyawa dari hasil sintesis ditentukan dengan spektrometer NMR dan IR. ================================================================= Heterocyclic compounds containing nitrogen atoms are important compounds in the chemical field of drugs, including indol and its derivatives are reported to have anti-cancer bioactivity. Based on the results of the literature study it can be hypothesized that 1,4-di- (indol-3-carbaldehyde-1-ilmethyl) benzene and 1,4-di- (indol-3-hydroxymethyl-1-ilmethyl) benzene have anticancer activity higher. The results showed 1.4-di- (indol-3-carbaldehyde-1-ilmethyl) benzene was obtained from the reaction between indole-3-carboxboxehyde and sodium hydride in acetonitrile with 99% yield. 1,4-di- (indol-3-hydroxymethyl-1-ilmethyl) benzene was obtained from the reduction of 1,4-di- (indol-3-carbaldehyde-1-ilmethyl) benzene process with sodium borohydride in ethanol with a yield of 80%. The structure of the compound of the synthesis product is determined by the NMR and IR spectrometers.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: turunan indol, sintesis, 1,4-di-(indol-3-karbaldehida-1-ilmetil)benzena, 1,4-di-(indol-3-karbaldehida-1-ilmetil)benzena, indol derivatives, synthesis
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Mathematics and Science > Chemistry > (S1) Undergraduate Theses
Depositing User: Ahmad Mudzakkirul Anam
Date Deposited: 26 Oct 2017 02:11
Last Modified: 05 Mar 2019 03:28
URI: http://repository.its.ac.id/id/eprint/48634

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