Sintesis Senyawa Kompleks Co(II) Dengan Ligan 2-Metil Imidazol dan 2,4,5-Trifenil-1H-Imidazol Sebagai Agent Anti Kanker

Harahap, Hotma Wardhani (2018) Sintesis Senyawa Kompleks Co(II) Dengan Ligan 2-Metil Imidazol dan 2,4,5-Trifenil-1H-Imidazol Sebagai Agent Anti Kanker. Masters thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Senyawa kompleks dari ion kobal(II) dengan ligan turunan imidazol yaitu 2-metil imidazol dan 2,4,5-trifenil-1H-imidazol disintesis dengan metode solvotermal pada suhu 120 oC selama 24 jam. Berdasarkan hasil dari analisis AAS dan mikrounsur C, H dan N diperoleh rumus molekul [(Co)2(2-metil imidazol)(H2O)10)].Cl4 dan [(Co)2(2,4,5-trifenil-1H-imidazol)(H2O)8)].Cl4. Nilai IC50 pada Senyawa kompleks [(Co)2(2-metil-imidazol)(H2O)10].Cl4 sebesar 0,699 µg/mL, melainkan pada [(Co)2(2,4,5-trifenil-imidazol)(H2O)8].Cl4 memiliki nilai IC50 sebesar 0,492 µg/mL. Nilai IC50 yang dihasilkan dari senyawa kompleks ini mendekati nol atau kurang dari 100 ppm, sehingga senyawa kompleks tersebut dapat berpotensi sebagai agent anti kanker. Hasil sintesis dikarakterisasi dengan spektrofotometer UV-Vis dan FT-IR, analisis AAS dan mikrounsur, TGA, SEM, MTT Assay. ======================================================================================================= The method used by the synthesis of complex compounds of cobalt (II) ions with imidazole derivative ligands are 2 - methyl imidazole and 2,4,5 - triphenyl - 1 H - imidazole is a solvotermal method at 120 °C for 24 hours. Based on the results of AAS and microunsure analysis C, H and N obtained the formula [(Co) 2 (2 - methyl imidazol)(H 2 O) 10 ) .Cl 4 and [(Co) 2 (2,4,5 - triphenyl - 1 H - imidazole)(H 2 O) 8 )].Cl 4 . The value of IC 50 on compound complex [(Co) 2 (2 - methyl imidazol)(H 2 O) 10 ).Cl 4 is 0, 699 μg / mL, but on [(Co) 2 (2,4,5 - triphenyl - 1 H - imidazole)(H 2 O) 8 )].Cl 4 is 0, 492 μg / mL. The value of IC 50 produced from this complex compound is less than 100 ppm, so that the compound can be potentially an anti - cancer agent. The synthesis results character ized by UV - Vis and FT - IR spectrophotometers, AAS and micro unsure analysis, TGA, SEM, MTT A ssay.

Item Type: Thesis (Masters)
Additional Information: RTKi 546 Har s-1 3100017072510
Uncontrolled Keywords: complex compound, imidazole derivative ligand, anti-cancer agent.
Subjects: Q Science > QD Chemistry
Q Science > QD Chemistry > QD471 Chemical compounds - Structure and formulas
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Mathematics and Science > Chemistry > 47001-(S3) PhD Thesis
Depositing User: HOTMA WARDHANI HARAHAP
Date Deposited: 19 Feb 2018 01:58
Last Modified: 16 Apr 2020 22:57
URI: http://repository.its.ac.id/id/eprint/48841

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