Pemisahan Dan Identifikasi Antioksidan Dan Inhibitor α-Glukosidase Dari Daun Salam

Hidayati, Mutia Devi (2015) Pemisahan Dan Identifikasi Antioksidan Dan Inhibitor α-Glukosidase Dari Daun Salam. Undergraduate thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Daun salam merupakan obat herbal yang tumbuh di Asia Tenggara. Pada penelitian ini, 3,4,5-trihidroksi-asam benzoat dan senyawa benzofuran telah diisolasi dari ekstrak metanol S. polyanthum dengan metode ekstraksi, partisi dan kromatografi. Struktur kimia telah ditentukan menggunakan data spektroskopi 1HNMR dan 13C-NMR. Uji aktivitas antidiabetes dilakukan menggunakan α-glukosidase menunjukkan bahwa asam galat dapat dikatakan aktif sebagai antidiabetes. Aktivitas asam galat sebagai antidiabetes berkaitan erat dengan sifatnya sebagai antioksidan. Asam galat menunjukkan penghambatan antioksidan melalui DPPH (2,2-diphenyl-2-picrylhydrazyl hydrate) dan ABTS (2,2’-azinobis (3-ethyl benzothiazoline-6-sulfonic acid) drazyl hydrate) ======================================================================================================= Syzygium polyanthum is a herbal medicine which is grown in South East Asia. In this study, 3,4,5-trihydroxy-benzoic acid and benzofuran compound puranol were isolated from methanol extract of S. polyanthum by extraction, partition and chromatography methods. The chemical structures were determined by using 1H-NMR and 13C-NMR spectroscopic data. Antidiabetic activity was done with α-glucosidase showed that gallic acid could be active as antidiabetic. Activity of gallic acid as antidiabetic closely related to its antioxidant activity. Gallic acid showed antioxidant inhibition on DPPH (2,2-diphenyl-2- picrylhydrazyl hydrate) and ABTS (2,2’-azinobis (3-ethyl benzothiazoline-6- sulfonic acid)

Item Type: Thesis (Undergraduate)
Additional Information: RTKi 660.284 2 Hid p
Uncontrolled Keywords: α-glukosidase, DPPH, ABTS.
Subjects: T Technology > TP Chemical technology > TP156 Crystallization. Extraction (Chemistry). Fermentation. Distillation. Emulsions.
Divisions: Faculty of Mathematics and Science > Chemistry > (S2) Master Theses
Depositing User: Mr. Tondo Indra Nyata
Date Deposited: 21 Mar 2018 04:26
Last Modified: 24 Aug 2018 03:10
URI: http://repository.its.ac.id/id/eprint/51596

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