Hepriyadi, Selvy Uftovia (2019) Pengukuran Kadar Glukosa pada Jaringan Kulit Tiruan Padat menggunakan Teknik Reflektansi Difus dengan Spektroskopi Near Infrared. Undergraduate thesis, Institut Teknologi Sepuluh Nopember.
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Abstract
Berdasarkan fakta mengenai potensi penyakit diabetes yang terus meningkat, maka perlu adanya suatu metode untuk memantau gula darah secara kontinu yang dapat dilakukan dengan metode non-invasif dari pengukuran berbasis optik. Salah satunya ialah dengan menggunakan metode Diffuse Reflectance Spectroscopy (DRS). Penelitian ini bertujuan untuk menentukan kadar glukosa pada solid phantom jaringan kulit berdasarkan parameter optik berupa koefisien penyerapan (µ_a) yang didapatkan dari karakterisasi absorbansi bahan penyusun phantom dan koefisien penghamburan tereduksi (〖µ'〗_s) yang didapatkan dari fitting terhadap spektrum reflektansi difus phantom. Berdasarkan eksperimen menunjukkan bahwa pengukuran kadar glukosa telah berhasil dilakukan pada rentang panjang gelombang 900 – 1300 nm dengan bahan penyusun phantom adalah air dan agar-agar sebagai agen penyerap dan baseline, serta intralipid sebagai agen penghambur. Metode DRS ini dapat digunakan untuk mengukur konsentrasi glukosa berdasarkan parameter koefisien absorbansi dan diperoleh korelasi antara konsentrasi hasil fitting terhadap konsentrasi regresi eksperimennya dengan persamaan y = 0.83634 + 0.58036x dan koefisien determinasi (R2) bernilai 0.98739. Berdasarkan Clarke Error Grid Analysis menunjukkan bahwa sistem pengukuran glukosa yang dilakukan telah dapat mendeteksi hingga konsentrasi glukosa 18 mM pada pasien diabetes yang sesuai dengan uji klinis.
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Based on the fact of the diabetes patients tended to incline, so it needs a method for continuous blood glucose monitoring from the optical measurements. One of them is by using Diffuse Reflectance Spectroscopy (DRS) on the wavelength region of near infrared (NIR). This study aims to determine the glucose level on the solid phantom using the theory of diffuse equation based on the optical parameters of absorption coefficient (µ_a) obtained by absorption characterization of constituent materials of the phantom and based on the reduced scattering coefficient (〖µ'〗_s) obtained by fitting program of diffuse reflectance spectra of the phantom. The experiments show that the measurements of the glucose level on the solid phantom were succeed using diffuse reflectance technique with the near infrared spectroscopy on the wavelength of 900 – 1300 nm. The phantom consists of the water as the absorption agent, agar-agar as the baseline, and the intralipid as the scattering agent. This method can be used for measuring the glucose level based on its absorption coefficient and was obtained the correlation between fitting concentrations and regression of experiment concentrations with the equation of y = 0.83634 + 0.58036x and the determination coefficient (R2) of 0.98739. Based on the Clarke Error Grid Analysis shows that the glucose measurement system can detect the glucose level of diabetes patients up to 18 mM clinically appropriate.
| Item Type: | Thesis (Undergraduate) |
|---|---|
| Additional Information: | RSF 543.5 Hep p-1 2019 |
| Uncontrolled Keywords: | Diffuse Reflectance Spectroscopy, Glukosa, Near Infrared, Solid Phantom |
| Subjects: | Q Science Q Science > QC Physics > QC162 Adsorption and absorption |
| Divisions: | Faculty of Industrial Technology and Systems Engineering (INDSYS) > Physics Engineering > 30201-(S1) Undergraduate Thesis |
| Depositing User: | Selvy Uftovia Hepriyadi |
| Date Deposited: | 13 Dec 2021 01:47 |
| Last Modified: | 19 Sep 2024 05:52 |
| URI: | http://repository.its.ac.id/id/eprint/61672 |
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