Goenawan, Joshua (2015) Pengaruh kadar H.O terlalu dalam karbon dioksida superkritis terhadap pembentukan kompleks inklusi ketoprofen-B- cyclodentrin. Undergraduate thesis, Institut Teknologi Sepuluh Nopember.
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Abstract
Obat yang dikonsumsi secaral oral banyak digunakan untuk
menyembuhkan berbagai jenis penyakit dikarenakan kemudahan
dalam mengkonsumsinya, fleksibilitas desain obat sesuai dosis
yang digunakan, dan resiko kemandulan yang rendah. Ketoprofen
merupakan salah satu jenis obat yang dikonsumsi secara oral.
Ketoprofen termasuk dalam golongan Non Steroidal Anti-
Inflammatory Drug (NSAID) yang memiliki kelarutan rendah
dalam air. Laju disolusi dapat ditingkatkan dengan pembentukan
kompleks inklusi ketoprofen dalam β-cyclodextrin menggunakan
karbon dioksida superkritis yang mengandung H2O terlarut.
Tujuan dari penelitian ini adalah mempelajari pengaruh kadar
H2O terlarut dalam karbon dioksida superkritis terhadap
persentase kompleks inklusi ketoprofen - β-cyclodextrin yang
terbentuk dan karakteristik kinerja obat. Penelitian ini diawali
dengan membuat campuran ketoprofen - β-cyclodextrin dengan
perbandingan berat 1:5 kemudian campuran disaturasi dengan
karbon dioksida superkritis yang mengandung H2O terlarut pada
berbagai suhu penjenuhan (30-50 oC) dan tekanan penjenuhan
130 bar serta suhu inklusi 50 oC pada berbagai tekanan inklusi
(150-200 bar) . Saturasi dilakukan selama ± 2 jam disertai dengan pengadukan. Beberapa metode analisis seperti Differential
Scanning Calorimetry (DSC), Scanning Electron Microscopy
(SEM), Drug Release dan Drug Loading akan digunakan untuk
mempelajari karakter dari kompleks inklusi. Persentase kompleks
inklusi yang dihasilkan sebesar 90,45% - 100%. Hasil uji drug
release menghasilkan persentase ketoprofen terlarut sebesar
79,85%-99,98% pada berbagai kadar air terlarut dalam CO2
superkritis dan berbagai tekanan inklusi.
======================================================================================================
Oral ingestion drugs are widely used to cure various
types of disease due to its ease of consuming the drug, flexibility
in the design of dosage form, and least sterility constraints.
Ketoprofen is one type of drug that is taken orally. Ketoprofen is
a Non Steroidal Anti-Inflammatory Drug (NSAID) which has low
solubility in water. The dissolution rate can be increased by
making inclusion complex of ketoprofen in β-cyclodextrin with
supercritical fluid (SCF) technology. The goals of this research
are to study the influence of H2O concentration in the
supercritical carbondioxide to the percentage of ketoprofen - β-
cyclodextrin inclusion complex and the performance
characteristic of the drug. This research begins with making a
mixture of ketoprofen - β-cyclodextrin by manually mixing them
with the weight ratio 1:5 then it is saturated by supercritical
carbondioxide at various saturation temperatures (30-50 oC) and
the saturation pressure of 130 bar with the temperature of
inclusion at 50 oC on various inclusion pressures (150-200 bar)
for about 2 hours and mixed continuously. The materials were
charactarized by Differential Scanning Calorimetry (DSC), drug loading, and drug release techniques. The percentage of the
inclusion complexes are 90,45% - 100%. The percentage
recovery of ketoprofen are 71,59%-99,43% and the percentage
drug released of ketoprofen are 79,85%-99,98% on various water
content in supercritical CO2 and various inclusion pressures.
| Item Type: | Thesis (Undergraduate) |
|---|---|
| Additional Information: | RSK 660.63 Goe p |
| Uncontrolled Keywords: | ketoprofen, cyclodextrin, kompleks inklusi, karbon dioksida, superkritis, air ================================================================================================ ketoprofen, cyclodextrin, inclusion complex, carbon dioxide, supercritical fluid (SCF), water |
| Subjects: | Q Science > QD Chemistry > QD75.2 Chemistry, Analytic |
| Divisions: | Faculty of Industrial Technology > Chemical Engineering > 24201-(S1) Undergraduate Thesis |
| Depositing User: | - Taufiq Rahmanu |
| Date Deposited: | 02 Apr 2019 03:34 |
| Last Modified: | 02 Apr 2019 03:34 |
| URI: | http://repository.its.ac.id/id/eprint/62683 |
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