Inayati, Kurnia Dwi (2015) Analisis survival pada pasien kanker serviks di RSUD Dr. Soetomo Surabaya menggunakan model cox stratifikasi. Undergraduate thesis, Institut Teknologi Sepuluh Nopember.
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Abstract
Kanker serviks adalah salah satu kanker yang menempati peringkat
teratas penyebab kematian perempuan di seluruh dunia termasuk
Indonesia. Tingginya angka kematian disebabkan karena rendahnya
kesadaran perempuan melakukan deteksi dini. Sebagian besar pasien
kanker serviks datang ke rumah sakit sudah dalam stadium lanjut.
Akibatnya pengobatan kanker serviks menjadi lebih sulit dan hasilnya
tidak memuaskan, bahkan cenderung mempercepat kematian. Salah satu
parameter yang dapat digunakan untuk menilai keberhasilan
pengobatan adalah probabilitas ketahanan hidup. Penelitian ini
mengangkat permasalahan ketahanan hidup pasien kanker serviks di
RSUD Dr. Soetomo Surabaya menggunakan model cox stratifikasi yang
didasarkan pada enam faktor yaitu usia, stadium, jenis pengobatan,
penyakit penyerta, komplikasi, dan status anemia. Model cox stratifikasi
digunakan karena terdapat satu variabel independen yang tidak
memenuhi asumsi proportional hazard, yaitu stadium. Hasil penelitian
menunjukkan, berdasarkan uji Log Rank terdapat perbedaan kurva
survival pada berbagai stadium, jenis pengobatan dan komplikasi. Dari
hasil model cox stratifikasi diperoleh faktor yang berpengaruh
signifikan yaitu komplikasi dengan nilai hazard ratio sebesar 7,839.
Artinya pasien kanker serviks yang mengalami komplikasi memiliki
resiko untuk meninggal 7,839 kali lebih besar dari pasien yang tidak
mengalami komplikasi. Sementara pada kurva adjusted survival
menunjukkan bahwa stadium IV memiliki probabilitas ketahanan hidup
paling rendah.
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Cervical cancer is one type of cancer that mostlly cause of the
women death around the world including Indonesia. The high mortality
rate because of the low awareness of women to do early detection. Most
cervical cancer patients come to the hospital already in an advanced
stage. As a result, the treatment of cervical cancer becomes more difficult
and the results are not satisfactory, and even can increase the death’s
risk. One of the parameters that can be used to assess the success of
treatment is the probability of survival. This study raises the issue of
survival patients with cervical cancer at Hospital Dr. Soetomo using cox
stratification model based on six factors such age, stage, type of
treatment, secondary disease, complications, and anemia status. Cox
stratification model is used because there is one independent variable that
does not satisfy the proportional hazards assumption, that is stage. The
results show, based on the Log Rank test there is a difference in the
survival curves of various stages, type of treatment and complications.
From the stratified cox model results obtained significant factor that is a
complication with the value of hazard ratio of 7.839. It means that
cervical cancer patients who experience complications are at risk of dying
7.839 times greater than patients who did not experience complications.
While the adjusted survival curves showed that stage IV had the lowest
probability of survival.
| Item Type: | Thesis (Undergraduate) |
|---|---|
| Additional Information: | RSSt 519.546 Ina a |
| Uncontrolled Keywords: | kanker serviks; ketahanan hidup; model cox stratifikasi; hazard ratio; kurva adjusted survival |
| Subjects: | H Social Sciences > HA Statistics > HA30.6 Spatial analysis |
| Divisions: | Faculty of Mathematics and Science > Statistics > 49201-(S1) Undergraduate Thesis |
| Depositing User: | - Taufiq Rahmanu |
| Date Deposited: | 19 Jun 2019 06:52 |
| Last Modified: | 19 Jun 2019 06:52 |
| URI: | http://repository.its.ac.id/id/eprint/63159 |
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