Adyarini, Prisna Ulvina (2019) Pemanfaatan Metoda Yamaguchi untuk Sintesis Tiga Pirazina-2-karboksamida. Other thesis, Institut Teknologi Sepuluh Nopember.
Preview |
Text
Prisna Ulvina Adyarini (01211540000003).pdf Download (1MB) | Preview |
Abstract
Pirazina-2-karboksamida memiliki kemampuan dalam menghambat perkembangan Mycobacterium tuberculosis, salah satunya adalah N-fenilpirazina-2-karboksamida. MDR-TB (Multi-drug Resistant Tuberculosis) atau resistensi ganda terhadap obat anti tuberkulosis merupakan salah satu masalah yang mengakibatkan penderita kebal terhadap obat anti tuberkulosis lini pertama. Pirazinamida adalah obat TB lini pertama yang penting dalam pengobatan tuberkulosis. Sintesis N-fenilpirazina-2-karboksamida umumnya dilakukan melalui dua tahap, yakni pembentukan asil klorida dan karboksamida. Penelitian yang dilakukan berhasil mensintesis tiga turunan N-fenilpirazina-2-karboksamida yakni N-(3,4,5-trimetoksimofenil)pirazina-2-karboksamida, N-(3,5-dimetoksimofenil)pirazina-2-karboksamida dan N-(3,4-dimetoksifenil)pirazina-2-karboksamida dengan metode Yamaguchi yang dapat berjalan secara one-pot. Senyawa hasil reaksi diduga memiliki aktivitas antimikobakteria dengan rendemen masing-masing 55%, 77% dan 69%.
=================================================================================================================================
Pyrazine-2-carboxamides have higher ability to inhibit the growth of Mycobacterium tuberculosis, one of those is N-phenylpyrazine-2-carboxamide. MDR-TB (Multi-drug Resistant Tuberculosis) is one of seriously problem causing the sufferer resistance with first line drugs. Pyrazinamide is an important first-line TB in the treatment of tuberculosis. The synthesis of N-phenylpirazine-2-carboxamide is generally carried out in two stages, namely the formation of acyl chloride and carboxamide. N-phenylpyrazine-2-carboxamides are generally synthesized by two pots reaction including the formation of acyl chloride and carboxamide. N-phenylpyrazine-2-carboxamide derivatives, N-(3,4,5-trimethoxyphenyl)pyrazine-2-carboxamide, N-(3,5-dimethoxyphenyl)pyrazine-2-carboxamide, and N-(3,4-dimethoxyphenyl)pyrazine-2-carboxamide, have been successfully synthesized using one pot Yamaguchi reaction and producing yields of 55%, 77% and 69%. The synthesized compounds are guessed having antimycobacterial activity.
| Item Type: | Thesis (Other) |
|---|---|
| Additional Information: | RSKi 613.286 Ady p-1 2019 |
| Uncontrolled Keywords: | N-fenilpirazina-2-karboksamida, sintesis, Yamaguchi, anti mikobakteria |
| Subjects: | Q Science Q Science > QD Chemistry Q Science > QD Chemistry > QD251.2 Chemistry, Organic. Biochemistry |
| Divisions: | Faculty of Natural Science > Chemistry > 47201-(S1) Undergraduate Thesis |
| Depositing User: | Prisna Ulvina Adyarini |
| Date Deposited: | 13 May 2024 05:45 |
| Last Modified: | 13 May 2024 05:45 |
| URI: | http://repository.its.ac.id/id/eprint/64901 |
Actions (login required)
 |
View Item |