Eksplorasi Senyawa Fenolat dan Uji Aktivitas Antioksidan dari Kulit Batang Garcinia latissima Miq.

Purbowati, Retno (2019) Eksplorasi Senyawa Fenolat dan Uji Aktivitas Antioksidan dari Kulit Batang Garcinia latissima Miq. Masters thesis, Insitut Teknologi Sepuluh Nopember.

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Abstract

Genus Garcinia dikenal dengan sebutan manggis-manggisan tersebar sebanyak 100 jenis di kawasan Asia Tenggara.Sebanyak 77 spesies diantaranya tumbuh di Indonesia. Tumbuhan dari genus Garcinia diketahui mempunyai banyak memiliki senyawa metabolit sekunder golongan fenolat diantaranya santon, flavonoid, benzofenon, depsidon dan triterpenoid. Senyawa fenolat tersebut dilaporkan mempunyai banyak aktivitas sebagai antioksidan, antidiabetes dan antikanker. Garcinia latissima Miq.merupakan tumbuhan endemik yang terdapat di Indonesia dan Papua Nugini yang dilaporkan mempunyai aktivitas anti mikrobial dan antioksidan. Isolasi senyawa metabolit sekunder yang dilakukan pada kulit batang tumbuhan tersebut mendapatkan senyawa piranosanton baru yaitu latissanton-A-D. Pada penelitian ini, dilakukan proses isolasi senyawa fenolat dan uji aktivitas antioksidan pada senyawa fenolat dari kulit batang G. latissima Miq. Dari hasil isolasi kulit batang didapatkan lima senyawa yang sudah diketahui yaitu 1,3,7-Trihidroksisanton (1), 1,3,6,7-Tetrahidroksi-2-prenilsanton (2), Kaempferol (3), Kuersetin (4), Asam Protokatesik (5). Uji antioksidan dilakukan dengan metode DPPH dengan hasil penghambatan di atas 80%.
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Genus Garcinia, well known as mangosteen family, consists of over 100 species and is widely distributed in Southeast Asia. Around 77 species of this genus grows throughout Indonesia. Garcinia have been identified to be a rich source of phenolic compounds, including xanthones, biflavonoids, benzophenones, depsidones, and triterpenoids. Some of the compounds have been reported to have several biological activities, such as antioxidant, antidiabetic, and anticancer. G. latissima Miq. is an endemic plant growing in Indonesia, especially in Papua Island, and its neighbouring country, Papua New Guinea. Previous reports have revealed antimicrobial and antioxidant activites of the leaves, fruits, and stem bark extracts of the plant. Phytochemical investigation of the stem bark of G. latissima Miq. led to the isolation of new pyranoxanthones, latisxanthones-A-D. In this work, the isolation and structural elucidation of secondary metabolites from the stem bark of G. latissima Miq. will be conducted, as well as antioxidant activity of the isolated compounds will be also performed. Five known compounds have isolated. They were 1,3,7-Trihydroksyxanthone (1), 1,3,6,7-Tetrahydroxy-2-prenilxanthone (2), Kaempferol (3), Quercetin (4), Protochautecic Acid (5). All compounds showed the inhibitory of DPPH more than 80%.

Item Type:	Thesis (Masters)
Uncontrolled Keywords:	Garcinia latissima Miq., Kaempferol, Santon, Kuersetin, Asam Protokatesik, Antioksidan
Subjects:	Q Science Q Science > QD Chemistry > QD251.2 Chemistry, Organic. Biochemistry
Depositing User:	Purbowati Retno
Date Deposited:	20 Jul 2026 06:39
Last Modified:	20 Jul 2026 06:39
URI:	http://repository.its.ac.id/id/eprint/69804

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