Pengembangan Material Pembawa Obat Kalsium Karbonat untuk Aplikasi Penghantaran Obat

Ramadhan, Fiqly Firnandi (2015) Pengembangan Material Pembawa Obat Kalsium Karbonat untuk Aplikasi Penghantaran Obat. Undergraduate thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Formulasi pembawa obat untuk sistem penghantaran obat Mengapung (Floating Drug Delivery Systems) berbasis Kalsium Karbonat, HPMC K15M dan Sodium Alginat telah dilaksanakan. Tujuan penelitian ini adalah untuk mengetahui pengaruh rasio material Drug Carrier (CaCO3, HPMC K15M, dan Sodium Alginat) terhadap floating behavior dan release kinetics. Serbuk kalsium karbonat dihasilkan dari ekstrak cangkang kerang hijau dan Kulit Telur. Sodium alginate digunakan sebagai crosslinking dengan ion Kalsium dan HPMC K15M digunakan sebagai peningkat bioavailabilitas obat. Obat yang digunakan adalah Aluminium Hidroksida sebagai obat lambung. Setiap formulasi dilakukan pengujian floating behavior untuk mengetahui waktu lag bouyancy dan bouyancy duration serta pengujian In vitro Dissolution untuk mengetahui konsentrasi pelepasan obat dan mekanisme pelepasan. Bermacam variabel formulasi seperti konsentrasi Kalsium Karbonat, HPMC K15M dan Sodium Alginat secara signifikan berpengaruh terhadap floating behavior dan pelepasan obat in vitro. Analisa untuk pola pelepasan obat pada tablet seperti Marshmallow menunjukan bahwa pelepasan obat mengikuti persamaan model First-order. ==================================================================================================== Formulations of the drug carrier for Floating Drug Delivery Systems based on Calcium Carbonate, HPMC K15M, and Sodium Alginate were implemented. The purpose of this study was to determine the influence of Drug Carrier materials (CaCO3, HPMC K15M, and Sodium Alginate) to floating behavior and release kinetics. Calcium Carbonate powder produced from the extract of green mussel shells and eggshells. Sodium Alginate was used as a crosslinking with calcium ions and HPMC K15M was used as a drug bioavailability enhancer. The drug used was Aluminium Hydroxide as stomach medicine. Each formulation was tested to determine floating behavior such as lag bouyancy time and bouyancy duration and In Vitro Dissolution Testing to determine the concentration of drug release and release mechanism. Various formulation variables such as the concentration of Calcium Carbonate, Sodium Alginate, and HPMC K15M significantly affected the floating behavior and In Vitro drug release. Analysis of the release pattern on the Marshmallow-like tablet showed that the drug release followed the First-order model.

Item Type: Thesis (Undergraduate)
Additional Information: RSMt 620.118 Ram p
Uncontrolled Keywords: Sistem Penghantaran Obat Mengapung, Kalsium Karbonat, Sodium Alginat, HPMC K15M, Alumunium Hidroksida
Subjects: T Technology > TA Engineering (General). Civil engineering (General) > TA418.9 Composite materials. Laminated materials.
Divisions: Faculty of Industrial Technology > Material & Metallurgical Engineering > 28201-(S1) Undergraduate Thesis
Depositing User: Yeni Anita Gonti
Date Deposited: 13 Feb 2020 07:19
Last Modified: 13 Feb 2020 07:19
URI: http://repository.its.ac.id/id/eprint/74890

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