Ningrum, Dwi Indah Latifah Pengaruh Pemberian Ekstrak Ikan Gabus (Channa Striata) Pada Struktur Histologi Hati Mencit (Mus Musculus) Hiperglikemik. Undergraduate thesis, Institut Teknologi Sepuluh Nopember Surabaya.
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Abstract
Kondisi hiperglikemik dapat menyebabkan kerusakan
jaringan hati. Pemberian albumin dapat meregenerasi jaringan
hati. Ekstrak ikan gabus (Channa striata) banyak mengandung
albumin sehingga dilakukan penelitian potensi ekstrak ikan gabus
untuk meregenerasi jaringan hati mencit (Mus musculus)
hiperglikemik.
Hiperglikemik pada mencit diinduksi dengan aloksan dosis
tunggal 190 mg/kg berat badan secara intraperitoneal. Terapi
menggunakan ekstrak ikan gabus dilakukan selama 14 hari
dengan dosis bervariasi. Pengukuran kadar glukosa darah
menggunakan glukometer Accu-Check Roche®. Preparasi
histologi hati mencit dengan metode irisan paraffin pewarnaan
haematoxylin-eosin, pengamatan dilakukan dengan mikroskop
fotografi Olympus® BX-41.
Hasil penelitian menunjukkan bahwa terapi ekstrak ikan
gabus dapat meregenerasi jaringan hati paling baik pada dosis
0,14846 ml/hari, dengan persentase perbaikan dari kondisi
hiperglikemik sebesar 80,56%
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Hyperglycemic conditions can cause tissue damage in the heart. Albumin can regenerate tissue of liver. Snake-head fish (Channa striata) extract contain of albumines so that researched about potential of snake-head fish extract to regenerate tissue of liver of white-mice (Mus musculus) hyperglycemic. Hyperglycemic of white-mice induced by alloxan single dose of 190 mg/kg body weight intraperitoneally. Therapy use snake-head fish extract conducted for 14 days with varying doses. Measurement of blood glucose level using glucometer of Roche Accu-Check®. Preparation of white-mice liver histology with paraffin slices method staining with haematoxylin-eosin, observations were made with a microscope photography of Olympus® BX-41. The results showed that the fish extract cork therapy can regenerate liver tissue are best at doses 0.14846 ml / day, with the percentage improvement of hyperglycemic condition by 80.56%
| Item Type: | Thesis (Undergraduate) |
|---|---|
| Additional Information: | RSBi 615.42 Nin p |
| Uncontrolled Keywords: | Channa striata, diabetes, glukosa darah, hati |
| Subjects: | Q Science > QD Chemistry > QD63 Extraction |
| Divisions: | Faculty of Natural Science > Biology > 46201-(S1) Undergraduate Thesis |
| Depositing User: | EKO BUDI RAHARJO |
| Date Deposited: | 11 Sep 2020 01:42 |
| Last Modified: | 11 Sep 2020 01:42 |
| URI: | http://repository.its.ac.id/id/eprint/81859 |
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