Simulasi Docking Molekuler Senyawa Trisindolina 1 Terhadap Protein Pi3k Pada Kanker Hepar (Hepatocellular Carcinoma)

Oktyasti, Evira Nadila (2021) Simulasi Docking Molekuler Senyawa Trisindolina 1 Terhadap Protein Pi3k Pada Kanker Hepar (Hepatocellular Carcinoma). Undergraduate thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Kanker hepar adalah kanker keenam yang paling sering terjadi di dunia. Jalur yang meregulasi terjadinya kanker hepar adalah PI3K AKT/mTOR yang berperan penting dalam apoptosis sehingga dapat digunakan dalam pengobatan kanker. Pengobatan kanker saat ini digunakan kemoterapi doxorubicin tetapi menimbulkan efek samping berupa MDR (Multi Drug Resistant) dan hepatotoksisitas. Penelitian ini dilakukan pengembangan obat anti kanker yang berasal dari bahan alam senyawa Trisindolina (3,3'-Di(indol-3-il)indolin-2-ona) yang merupakan simbion spons Hyrtios altum dengan bakteri Vibrio sp. Penelitian ini bertujuan untuk mengetahui aktivitas Trisindolina 1 secara in silico dengan target jalur PI3K pada kanker hepar. Metode yang dilakukan adalah docking molekuler menggunakan Autodock Vina terhadap protein PI3K dengan kontrol positif obat doxorubicin. Hasil docking menunjukkan bahwa Trisindolina 1 berpotensi sebagai inhibitor protein PI3K pada jalur PI3K kanker hepar melalui apoptosis.
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Liver cancer is the sixth most common cancer in the world. The pathway that regulates the occurrence of liver cancer is PI3K AKT/mTOR which plays an important role in apoptosis so that it can be used in cancer treatment. Cancer treatment is currently using doxorubicin chemotherapy but it causes side effects in the form of MDR (Multi Drug Resistant) and hepatotoxicity. This research was conducted to develop an anti-cancer drug derived from the natural compound Trisindoline (3,3'-Di(indole-3-yl)indolin-2-ona) which is a symbiont of the sponge Hyrtios altum with the bacterium Vibrio sp. This study aims to determine the activity of Trisindolina 1 in silico with the target of the PI3K pathway in liver cancer. The method is molecular docking using Autodock Vina against PI3K protein with a positive control of doxorubicin. The docking results show that Trisindolina 1 has the potential as an inhibitor of PI3K protein in the PI3K pathway of liver cancer through apoptosis.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Apoptosis, Cancer, Docking, PI3K, Trisindoline 1, Apoptosis, Docking, Hepar, Kanker, PI3K, Trisindolina 1
Subjects:	Q Science > QL Zoology Q Science > QR Microbiology Q Science > QR Microbiology > QR 201.T84 Tumors. Cancer
Divisions:	Faculty of Science and Data Analytics (SCIENTICS) > Biology > 46201-(S1) Undergraduate Thesis
Depositing User:	Evira Nadila Oktyasti
Date Deposited:	18 Jul 2021 05:33
Last Modified:	18 Jul 2021 05:33
URI:	http://repository.its.ac.id/id/eprint/84372

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