Analisis Biomekanik Dan Biodegradasi Injectable Silicone Rubber/PVA/ZrO2 Sebagai Kandidat Material Pengganti Nucleus Pulposus

syahani, Mellinda Tita Ayu (2021) Analisis Biomekanik Dan Biodegradasi Injectable Silicone Rubber/PVA/ZrO2 Sebagai Kandidat Material Pengganti Nucleus Pulposus. Undergraduate thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Penanganan Low Back Pain melalui metode pembedahan membutuhkan material yang dapat menggantikan Nucleus Pulposus (NP). Penggantian dilakukan dengan metode injeksi untuk mencegah hilangnya ketinggian. Material yang digunakan untuk harus bersifat biokompatibel. Hidrogel PVA adalah kandidat sesuai material pengganti NP namun sifat mekaniknya belum memenuhi karakteristik NP. Disisi lain Silicone Rubber memiliki stabilitas serta elastisitas tinggi. Selain SR/PVA penambahan material radiopak diperlukan untuk memudahkan deteksi x-ray ketika dalam tubuh. Penelitian ini dilakukan untuk mengetahui performa SR/PVA setelah penambahan radiopak ZrO2 dengan variasi Hydrogel PVA-ZrO2 yang digunakan 0, 0.5, 1, 1.5, 3 dan 5%. Dari hasil pengujian curing time didapatkan penambahan waktu 3-4 menit setelah penambahan ZrO2. Analisis hasil pengujian tekan didapatkan peningkatan sifat mekanik setelah penambahan ZrO2 dan perendaman dengan PBS. Dari pengujian SEM-EDX didapatkan penurunan porositas pada penambahan ZrO2. Disamping itu terdapat penurunan porositas pada saat perendaman dengan PBS. Dari pengujian Biodegradasi didapatkan prediksi lifetime dari sampel dengan hasil terbaik pada sampel SR/PVA/ZrO2 0,5% dengan 21 bulan. Hasil terbaik dari penelitian adalah sampel SR/PVA/ZrO2 1.5% karena telah memenuhi standar kekuatan dan memiliki waktu degradasi yang baik yaitu 18 bulan.
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Treatment of Low Back Pain through the surgical method requires a material that can replace the Nucleus Pulposus (NP). Replacement is done by injection method to prevent loss of height. The material used for this must be biocompatible. PVA hydrogel is a suitable candidate for NP replacement material but its mechanical properties do not meet the characteristics of NP. On the other hand, Silicone Rubber has high stability and elasticity. In addition to SR/PVA the addition of radiopaque material is needed to facilitate x-ray detection when in the body. This study was conducted to determine the performance of SR/PVA after the addition of radiopaque ZrO2 with variations of Hydrogel PVA-ZrO2 used 0, 0.5, 1, 1.5, 3 and 5%. From the results of the curing time test, it was found that the addition of 3-4 minutes after the addition of ZrO2. Analysis of the results of the compression test showed an increase in mechanical properties after the addition of ZrO2 and immersion with PBS. From the SEM-EDX test, it was found that the porosity decreased with the addition of ZrO2. In addition, there is a decrease in porosity during immersion with PBS. From the Biodegradation test, it was found that the lifetime prediction of the sample with the best results was in the 0.5% SR/PVA/ZrO2 sample with 21 months. The best result from this study was the 1.5% SR/PVA/ZrO2 sample because it had met the standard of strength and had a good degradation time of 18 months.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	ZrO2, Silicone Rubber, PVA, Injectable Material, ZrO2, Silicone Rubber, PVA, Injectable Material
Subjects:	T Technology > TP Chemical technology > TP1140 Polymers T Technology > TP Chemical technology > TP156.C64 Controlled release technology
Divisions:	Faculty of Industrial Technology and Systems Engineering (INDSYS) > Material & Metallurgical Engineering
Depositing User:	Mellinda Tita Ayu Syahani
Date Deposited:	12 Aug 2021 12:01
Last Modified:	12 Aug 2021 12:01
URI:	http://repository.its.ac.id/id/eprint/85833

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