In-Vivo Nanochitosan Therapeutic Agent untuk Metal Toxic Implant

Anggraeni, Amelia (2021) In-Vivo Nanochitosan Therapeutic Agent untuk Metal Toxic Implant. Undergraduate thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Logam implan yang sering digunakan yaitu paduan CoCrMo, Stainless Steel, dan paduan Titanium. Lingkungan tubuh yang korosif dapat menyebabkan terjadinya pelepasan ion logam pada paduan CoCrMo. Cr6+ merupakan ion toksik pertama di dunia. Salah satu efek dari ion Cr6+ dapat menyebabkan gangguan sistem pernapasan, iritasi kulit, kanker, dan gangguan pada ginjal. Sehingga perlu adanya penelitian mengenai therapeutic agent untuk mengadsorpsi ion logam Cr6+. Kitosan dipilih sebagai therapeutic agent untuk mengatasi toksisitas ion logam Cr6+. Penelitian ini bertujuan untuk menganalisis konsentrasi kitosan dan presentase kitosan yang efektif dalam mengadsorbsi ion logam dengan metode In-Vivo. Metode in-Vivo menggunakan tikus Wistar (310±40gr) yang diinjeksikan secara intraperitoneal dengan 6mg/kg bb/hari kalium dikromat setiap 2 kali seminggu selama 3 minggu, kemudian diberikan kitosan secara oral setiap hari selama 6 minggu dengan variasi kitosan 0,5mg/L dan 2mg/L. Dilakukan pengujian AAS, X-Ray, dan pengamatan secara visual. Kemudian didapatkan hasil konsentrasi adsorpsi Cr optimum pada 2mg/L sebesar 92,46% sedangkan pada 0,5mg/L sebesar 92,45%.
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Implant metals that are often used are CoCrMo alloys, stainless steel, and titanium alloys. The corrosive body environment can cause the release of metal ions in the CoCrMo alloy. Cr6+ is the first toxic ion in the world. One of the Cr6+ ion effects can cause respiratory system disorders, skin irritation, cancer, and kidney disorders. So it is necessary to research therapeutic agents to adsorb Cr6+ metal ions. Chitosan was chosen as a therapeutic agent to overcome the toxicity of the Cr6+ alkaline ion. This study aims to measure the concentration of chitosan and present chitosan, which effectively adsorbs metal ions using the In-Vivo method. The in-Vivo method used Wistar mice (310 ± 40gr) injected intraperitoneally with 6 mg/kg BW/day of potassium dichromate every two times a week for three weeks chitosan orally every day for six weeks with variations of chitosan 0,5mg/L and 2mg/L. AAS, X-Ray, and visual observations were performed. Then the results obtained the optimum Cr adsorption concentration at 2mg/L was 92.46% while at 0.5mg/L was 92.45%.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	CoCrMo,Ion, Kitosan,In-Vivo,CoCrMo,Ion, Chitosan,In-Vivo
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisions:	Faculty of Industrial Technology and Systems Engineering (INDSYS) > Material & Metallurgical Engineering > 28201-(S1) Undergraduate Thesis
Depositing User:	Amelia Anggraeni
Date Deposited:	12 Aug 2021 07:27
Last Modified:	12 Aug 2021 07:27
URI:	http://repository.its.ac.id/id/eprint/85838

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