Putra, Akbar Anugrah (2021) Rancang Bangun Sistem Pengukuran Senyawa Bio (Glukosa) Pada Μpad Termodifikasi Material Nano Mox (M= Ti, Zn) Dengan Teknik Kolorimetri. Undergraduate thesis, Institut Teknologi Sepuluh Nopember.
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Abstract
Mikrofluida saat ini dikembangkan sebagai peranti point of care (PoC) diagnostic untuk layanan kesehatan dengan akses fasilitas medis yang terbatas karena beberapa keunggulannya, yaitu konsumsi bahan yang sedikit, resolusi dan sensitivitas yang tinggi, serta waktu analisis yang cepat. Pada penelitian ini dikembangkan alat ukur konsentrasi glukosa pada darah dengan metode kolorimetri dengan menggunakan kertas mikrofluida (microfluidic paper-based analytical device, μPAD). Pemisahan glukosa darah dibantu dengan material nano ZnO dan TiO2. Adapun, kuantifikasi konsentrasi glukosa dibantu dengan menggunakan pengolahan citra dengan memanfaatkan intensitas dari ruang warna RGB, HSV dan grayscale. Analisis dilakukan dengan mengukur intensitas warna pada konsentrasi glukosa yang bervariasi untuk mengetahui ruang warna yang memiliki sensitivitas dan akurasi terbaik untuk mengukur kadar glukosa serta pengaruh penambahan material nano terhadap pengukuran. Hasil validasi menunjukkan bahwa alat ukur dengan penggunaan material nano TiO2 memiliki error sebesar 13.4% yang telah sesuai dengan standar. Serta, alat ukur yang dirancang membutuhkan biaya pengujian yang lebih kecil dengan yang ada di pasar. Penambahan material nano TiO2 menyebabkan perubahan signifikan pada rata – rata korelasi yang meningkat sebesar 34.5%. Sedangkan, penambahan material nano ZnO menyebabkan perubahan signifikan pada sensitivitas pengukuran yang menurun sebesar 56.9%.
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Microfluidics is currently being developed as a point of care (PoC) diagnostic device for health services with limited access to medical facilities due to the advantages of low material consumption, high resolution and sensitivity, and fast analysis time. In this study, a measurement setup for quantifying the concentration of glucose in the blood was developed using the colorimetric method on paper-based microfluidic (μPAD) platform. Separation of blood glucose was assisted with ZnO and TiO2 nanomaterial, while the quantification of glucose concentration employed image processing technique by evaluating the intensity of different color spaces including RGB, HSV, and the grascale. The analysis was carried out by measuring the color intensity at various glucose concentrations to determine the color space that has the best sensitivity and accuracy for measuring glucose levels ad the effect of adding material nanos to the measurement. The validation results show that the device with the use of TiO2 material nano has an error of 13.4% which is in accordance with the standard. Also, the designed measuring instruments require less testing costs than on the market. The addition of TiO2 caused a significant change in the average correlation which increased by 34.5%. Meanwhile, the addition of ZnO caused a significant change in the measurement sensitivity which decreased by 56.9%.
| Item Type: | Thesis (Undergraduate) |
|---|---|
| Uncontrolled Keywords: | μPAD, Kolorimetri, TiO2, ZnO, Colorimetric |
| Subjects: | T Technology > TA Engineering (General). Civil engineering (General) > TA1573 Detectors. Sensors T Technology > TA Engineering (General). Civil engineering (General) > TA1637 Image processing--Digital techniques T Technology > TP Chemical technology > TP248 Nanogels. Nanoparticles. |
| Divisions: | Faculty of Industrial Technology > Physics Engineering > 30201-(S1) Undergraduate Thesis |
| Depositing User: | Akbar Anugrah Putra |
| Date Deposited: | 22 Aug 2021 14:06 |
| Last Modified: | 22 Aug 2021 14:06 |
| URI: | http://repository.its.ac.id/id/eprint/88466 |
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