Analisis Risiko Kekambuhan Stroke Iskemik di Rumah Sakit PHC Surabaya Menggunakan Model Prentice, Williams, and Peterson Gap Time (PWP-GT)

Hilaly, Sakinah Salsabilillah (2021) Analisis Risiko Kekambuhan Stroke Iskemik di Rumah Sakit PHC Surabaya Menggunakan Model Prentice, Williams, and Peterson Gap Time (PWP-GT). Undergraduate thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Berdasarkan laporan internal yang disusun oleh RS PHC Surabaya tahun 2015-2019, stroke iskemik termasuk 10 besar penyakit dengan kasus rawat inap terbanyak. Tingkat kekambuhan sebesar 15% dan tingkat kematian sebesar 5.5%. Analisis Kaplan-Meier menghasilkan taksiran bahwa peluang seorang pasien untuk mengalami kekambuhan setahun setelah stroke pertama sebesar 10%. Kemudian risiko tersebut meningkat dari 10% ke 30% dalam empat tahun. Risko kekambuhan kedua meningkat dari 30% ke 45% dalam tiga tahun. Risiko kekambuhan ketiga meningkat dari 40% ke 80% dalam tiga tahun. Uji Wald terhadap koefisien regresi dari model PWP-GT mengonfirmasi bahwa terdapat empat faktor risiko yang berpengaruh terhadap kekambuhan pertama stroke iskemik, sedangkan kekambuhan kedua dan ketiga tidak dipengaruhi oleh faktor risiko apapun yang ada di dalam model. Penyakit jantung koroner memperbesar risiko kekambuhan stroke iskemik pertama sebesar 60.5% (CI 8% - 238%), diabetes mellitus memperbesar risiko kekambuhan stroke iskemik pertama sebesar 41.2% (CI 14% - 75%), dislipidemia memperbesar risiko kekambuhan pertama sebesar 20.7% (CI 2% - 44%), dan risiko kekambuhan pertama pada pasien lanjut usia (>60 tahun) 49.8% lebih besar daripada pasien yang lebih muda (CI 6% - 212%).
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Based on an internal report compiled by the Medical Records Unit of the Primasatya Husada Citra Hospital (RS PHC) Surabaya in 2015-2019, ischemic stroke is one of the top 10 diseases with the most hospitalized cases. The recurrence rate was 15%, while the mortality rate was 5.5%. The Kaplan-Meier analysis yields an estimate that a patient's chance of having a recurrence one year after the first stroke is 10%. The risk then increases from 10% to 30% within three years. The chance of a second recurrence increases from 30% to 45% within three years. PWP-GT model was built and Wald test was performed to check the significance of the regression coefficients. The test confirmed that there were four risk factors that significantly influence the first recurrence of ischemic stroke, meanwhile the second and third recurrences are not influenced by any risk factor in the model. Coronary heart disease increased the risk of ischemic stroke first recurrence by 60.5% (CI 8% - 238%), diabetes mellitus increased the risk of first recurrence by 41.2% (14% - 75% CI), dyslipidemia increased the risk of first recurrence by 20.7% (CI 2% - 44%), and the risk of first recurrence in elderly patients (>60 years) was 49.8% greater than in younger patients (CI 6% - 212%).

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Kekambuhan, Kurva Kaplan-Meier, Model PWP-GT, Faktor risiko, Stroke Iskemik, Ischemic Stroke, Kaplan-Meier Curve, PWP-GT Model, Recurrence, Risk Factor
Subjects:	R Medicine > R Medicine (General) > R853.S7 Survival analysis (Biometry)
Divisions:	Faculty of Science and Data Analytics (SCIENTICS) > Statistics > 49201-(S1) Undergraduate Thesis
Depositing User:	Sakinah Salsabilillah Hilaly
Date Deposited:	31 Aug 2021 03:07
Last Modified:	31 Aug 2021 03:07
URI:	http://repository.its.ac.id/id/eprint/90760

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