Penentuan Parasetamol Menggunakan Screen Printed Carbon Electrode

Bahar, Setyadi Laksono (2022) Penentuan Parasetamol Menggunakan Screen Printed Carbon Electrode. Masters thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Screen printed carbon electrode digunakan untuk mendeteksi parasetamol dengan metode voltametri siklik. Pengukuran voltametri siklik dilakukan pada rentang potensial -750 mV hingga 1000 mV pada suhu ruang. Parasetamol dalam 0,1 M pelarut buffer fosfat dapat dideteksi pada pH 5, 7, dan 9 melalui arus puncak oksidasinya, namun parasetamol dapat dideteksi melalui arus puncak reduksi pada pH 9. Berdasarkan persamaan Randels-Sevcik, regresi linier arus puncak oksidasi dan arus puncak reduksi terhadap akar scan rate mengindikasikan interaksi screen printed carbon electrode dan parasetamol dikendalikan oleh difusi. Sedangkan screen printed carbon electrode memiliki limit deteksi 0,70 µM untuk arus puncak oksidasi dan 0,57 µM untuk arus puncak reduksi serta memiliki sensitivitas 0,007 μA.mm-2.μM-1 untuk puncak arus anoda dan 0,005 μA.mm-2.μM-1 untuk puncak arus katoda.. Parasetamol dalam 0,1 M pelarut buffer fosfat dapat dideteksi secara spesifik tanpa adanya gangguan dari asam urat, asam askorbat, glukosa, urea.
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The screen printed carbon electrode performance was observed using cyclic voltammetry (CV) in 0,1 M phosphate buffer solution at various pH. The measurement was done at a potential range from -750 mV to 1000 mV at room temperature. The response of screen printed carbon electrode shows that paracetamol can be detected clearly from its oxidation (0,63 V) and reduction (-0,352 V) peaks in 0,1 M phosphate buffer solution at pH 9. The limit of detection (LOD) of the screen printed carbon electrode to detect paracetamol was 0,70 µM and 0,57 µM for oxidation and reduction peaks, respectively. Sensitivity of the screen printed carbon electrode to detect paracetamol was 0,168 μA.mm-2.μM-1 for oxidation peak dan 0,177 μA.mm-2.μM-1 for reducyion peak. The reaction between the screen printed carbon electrode and paracetamol demonstrated diffusion-controlled behavior. The selectivity study indicates no interference signal from ascorbic acid, urea, uric acid, and glucose during paracetamol measurement.

Item Type:	Thesis (Masters)
Uncontrolled Keywords:	Paracetamol, screen printed carbon electrode, cyclic volatmmetry, parasetamol, voltametri siklik
Subjects:	Q Science > QD Chemistry > QD553 Electrochemistry. Electrolysis
Divisions:	Faculty of Science and Data Analytics (SCIENTICS) > Chemistry > 47101-(S2) Master Thesis
Depositing User:	Setyadi Laksono Bahar
Date Deposited:	12 Jul 2022 01:26
Last Modified:	31 Oct 2022 02:23
URI:	http://repository.its.ac.id/id/eprint/94990

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