`Arifah, Fadhila Rosyidatul (2023) Analisis Pengaruh Penambahan 3-Glycidoxypropyltrimethoxysilane dan Variasi Komposisi Filler Pada β-TCP/HA/PEEK Terhadap Sifat Mekanik, Morofologi, dan Biodegradabilitas Untuk Aplikasi Spinal Implant. Diploma thesis, Institut Teknologi Sepuluh Nopember.
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Abstract
Implan tulang merupakan salah satu produk rekayasa material di bidang biomedis. Beberapa material telah diteliti untuk mengetahui efektivitas serta kelebihan dan kekurangan dalam penggunaannya sebagai implan tulang. Material yang umum digunakan dan tersedia secara komersial sebagai implan tulang saat ini adalah logam, namun material ini memiliki beberapa kekurangan, misalnya perlu dilakukan tindakan operasi kedua untuk pengambilan implan dikarenakan sebagian besar logam yang digunakan tidak dapat terdegradasi di dalam tubuh. Oleh karena itu, seiring dengan perkembangan teknologi maka diperlukan implan tulang yang terbuat dari material yang memiliki sifat biokompatibilitas (biocompatible), mudah terurai (biodegradable), dan bioactive. Pada penelitian ini digunakan material komposit β-TCP/HA/PEEK dengan variasi persentase penambahan coupling agent 3-Glycidoxypropyltrimethoxysilane sebesar 0%, 1%, 3%, dan 5%, serta variasi komposisi filler β-TCP/HA sebesar 100% β-TCP, 70% β-TCP : 30% HA, 30% β-TCP : 70% HA, dan 100% HA untuk mengetahui bagaimana pengaruhnya terhadap sifat mekanik, morfologi, dan biodegradabilitas untuk aplikasi spinal implant. Hasil penelitian menunjukkan bahwa persentase penambahan coupling agent dan komposisi filler pada komposit β-TCP/HA/PEEK berpengaruh secara signifikan terhadap sifat mekanik, morfologi, dan biodegradabilitas spinal implant. Material yang kemungkinan mendekati paling sesuai untuk aplikasi spinal implant yaitu komposit β-TCP/HA/PEEK 1% 3-Glycidoxypropyltrimethoxysilane yang memiliki compressive strength sebesar 22,57 MPa dan prediksi waktu degradasi selama 47,6 bulan, serta komposit β-TCP/HA/PEEK 5% 3-Glycidoxypropyltrimethoxysilane dengan komposisi filler 70% β-TCP : 30% HA yang memiliki compressive strength sebesar 43,00 MPa dan prediksi waktu degradasinya selama 43,3 bulan.
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Bone implants are a material engineering product in the biomedical field. Several materials have been studied to determine their effectiveness and advantages and disadvantages in their use as bone implants. The material that is commonly used and commercially available as bone implants today is metal, but this material has several disadvantages, for example it is necessary to perform a second operation to remove the implant because most of the metal used cannot be degraded in the body. Therefore, along with technological developments, bone implants made of materials that are biocompatible, biodegradable, and bioactive are needed. In this study, β-TCP/HA/PEEK composite materials were used with variations in the percentage of addition of coupling agent 3-Glycidoxypropyltrimethoxysilane of 0%, 1%, 3%, and 5%, as well as variations in the composition of β-TCP/HA filler of 100% β- TCP, 70% β-TCP : 30% HA, 30% β-TCP : 70% HA, and 100% HA to find out how it affects the mechanical property, morphology, and biodegradability for spinal implant applications. The results showed that the percentage of addition of coupling agent and filler composition to the β-TCP/HA/PEEK composite had a significant effect on the mechanical property, morphology, and biodegradability of spinal implants. The material that is likely to be the most suitable for spinal implant applications is the β-TCP/HA/PEEK composite 1% 3-Glycidoxypropyltrimethoxysilane which has a compressive strength of 22,57 MPa and a predicted degradation time of 47,6 months, and the β-TCP/HA/PEEK composite 5% 3-Glycidoxypropyltrimethoxysilane with a filler composition of 70% β-TCP : 30% HA which has a compressive strength of 43,00 MPa and a predicted degradation time of 43,3 months.
| Item Type: | Thesis (Diploma) |
|---|---|
| Additional Information: | RSMt 617.95 Ari a-1 |
| Uncontrolled Keywords: | Biodegradable, Filler Composition, β-TCP/HA/PEEK Composite, Percentage of Coupling Agent 3-Glycidoxypropyltrimethoxysilane, Spinal Implant, Komposisi Filler, Komposit β-TCP/HA/PEEK, Persentase Coupling Agent 3-Glycidoxypropyltrimethoxysilane, Spinal Implant. |
| Subjects: | R Medicine > R Medicine (General) > R857.M3 Biomedical materials. Biomedical materials--Testing. T Technology > T Technology (General) > TA404 Materials--Biodegradation |
| Divisions: | Faculty of Industrial Technology and Systems Engineering (INDSYS) > Material & Metallurgical Engineering > 28201-(S1) Undergraduate Thesis |
| Depositing User: | Fadhila Rosyidatul Arifah |
| Date Deposited: | 08 Feb 2023 02:09 |
| Last Modified: | 24 Aug 2023 08:56 |
| URI: | http://repository.its.ac.id/id/eprint/96296 |
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