Sintesis Biokomposit PCL/PLLA dengan Variasi Nano Hidroksiapatit sebagai Reinforce untuk Aplikasi Bone Plate

Salsah, Rizka Putri (2023) Sintesis Biokomposit PCL/PLLA dengan Variasi Nano Hidroksiapatit sebagai Reinforce untuk Aplikasi Bone Plate. Masters thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Implan merupakan salah satu alat fiksasi internal yang sedang dikembangkan di Indonesia. Material implan yang dikembangkan harus mempunyai sifat biokompetitif, biodegradable, dan bioaktif. Oleh karena itu, penelitian ini bertujuan membuat bone plate biokomposit dengan campuran matriks polycaprolactone (PCL) dan poly(l-lactic acid) (PLLA) dengan filler nano hidroksiapatit (nHA) dan menganalisis pengaruh dari rasio komposisi biopolimer PCL dan PLLA dan komposisi nHA terhadap morfologi, sifat mekanik, biodegradasi serta cell viability. PCL dan PLLA digunakan karena mempunyai sifat mekanik yang lebih tinggi, biodegradable, biokompatibel, dan tidak beracun bagi tubuh manusia. Nano hidroksiapatit digunakan karena mempunyai sifat biokompatibilitas dan bioaktivitas yang baik. Variasi pada penelitian ini yaitu komposisi rasio PCL dan PLLA yang dicampur sebesar 70:30, 80:20, dan 90:10 dan nHA yang telah dimodifikasi ditambahkan kepada PCL/PLLA 80:20 dengan rasio PCL/PLLA:nHA sebesar 70:30, 80;20, 90:10. Hasil analisi Fourier-Transform Infrared Spectroscopy (FTIR) dan Nuclear Magnetic Resonance (NMR) mengkonfirmasi ikatan pada nHA yang dimodifikasi 3-Aminopropyltriethoxysilane (APTES). Hasil morfologi dan unsur menggunakan alat Scanning Electron Microscopy (SEM)/Energy-Dispersive X-Ray Spectroscopy (EDX) menunjukkan seiiring penambahan PLLA meningkatkan kekasaran pada permukaan sedangkan penambahan dari nHA tidak memperlihatkan perbedaan yang signifikan. Hasil analisis Transmission Electron Microscopy (TEM) menunjukkan morfologi dari nHA yang dimodifikasi APTES berbentuk spherical. Hasil analisis pengujian tarik menunjukkan kekuatan tarik maksimal terdapat pada sampel PPHA 732 sebesar 6,69 MPa. Hasil analisis pengujian tekan menunjukkan kekuatan tekan tekan terbaik pada sampel PPHA 732 sebesar 8,97 MPa. Hasil pengujian weight loss menunjukkan seiring penambahan PLLA dan nHA mempercepat biodegradasi biokomposit. Hasil biodegradasi terbaik dengan degradation time 6 – 8,3 bulan terdapat pada sampel PPHA 912, PPHA 822, dan PPHA 732 yaitu secara berturut-turut sebesar 6,436, 7,137, dan 7,92 bulan. Hasil analisis cell viability dari komposit PCL:PLLA/nHA menunjukkan penambahan PLLA dan nHA meningkatkan %cell viability dengan variasi terbaik didapatkan pada sampel PPHA 823 sebesar 86,87% cell viability.
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Implants are one of the internal fixation tools being developed in Indonesia. The implant material developed must have biocompetitive, biodegradable, and bioactive properties. Therefore, this study aims to make biocomposite bone plates with a mixture of polycaprolactone (PCL) and poly(l-lactic acid) (PLLA) matrix with nano hydroxyapatite (nHA) filler and analyze the effect of the ratio of PCL and PLLA biopolymer compositions and nHA composition on morphology, mechanical properties, biodegradation and cell viability. PCL and PLLA are used because they have higher mechanical properties, biodegradable, biocompatible, and non-toxic to the human body. Nano hydroxyapatite is used because it has good biocompatibility and bioactivity properties. Variations in this study were the composition of mixed PCL and PLLA ratios of 70:30, 80:20, and 90:10 and modified nHA was added to PCL/PLLA 80:20 with a ratio of PCL/PLLA:nHA of 70:30, 80;20, 90:10. The results of Fourier-Transform Infrared Spectroscopy (FTIR) and Nuclear Magnetic Resonance (NMR) analysis confirmed the binding of nHA modified by 3-Aminopropyltriethoxysilane (APTES). Morphological and elemental results using Scanning Electron Microscopy (SEM)/Energy-Dispersive X-Ray Spectroscopy (EDX) showed that the addition of PLLA increased the surface roughness while the addition of nHA did not show a significant differences. The results of the Transmission Electron Microscopy (TEM) analysis showed that the morphology of the nHA modified by APTES was spherical in shape. The results of the tensile test analysis showed that the maximum tensile strength was found in the PPHA 732 sample of 6.69 MPa. The results of the compressive test analysis showed that the best compressive strength in the PPHA 732 sample was 8.97 MPa. The results of the weight loss test showed that the addition of PLLA and nHA accelerated the biodegradation of biocomposites. The best biodegradation results with a degradation time of 6 – 8.3 months were found in the PPHA 912, PPHA 822, and PPHA 732 samples, namely 6.436, 7.137 and 7.92 months respectively. The results of cell viability analysis of the PCL:PLLA/nHA composite showed that the addition of PLLA and nHA increased % cell viability with the best variation obtained in the addition of 30% nHA of 86.87% cell viability.

Item Type:	Thesis (Masters)
Uncontrolled Keywords:	Biokomposit, PCL, PLLA, Nano Hidroksiapatit, Biocomposite, Nano Hydroxyapatite
Subjects:	Q Science > QC Physics > QC173.4.C63 Composite materials Q Science > QP Physiology > QP801.P64 Polymers--Biodegradation T Technology > TP Chemical technology > TP1140 Polymers
Divisions:	Faculty of Industrial Technology and Systems Engineering (INDSYS) > Material & Metallurgical Engineering > 27101-(S2) Master Thesis
Depositing User:	Rizka Putri Salsah
Date Deposited:	13 Feb 2023 02:09
Last Modified:	13 Feb 2023 02:09
URI:	http://repository.its.ac.id/id/eprint/96754

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