Analisis Pengaruh Feed Rate Electrospinning dan Rasio Polimer terhadap Karakteristik dan Performa Wound Healing Komposit Nanofiber PAN/Cu2O Quantum Dots

Perkasa, Bintang Panji (2023) Analisis Pengaruh Feed Rate Electrospinning dan Rasio Polimer terhadap Karakteristik dan Performa Wound Healing Komposit Nanofiber PAN/Cu2O Quantum Dots. Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Penggunaan antibiotik dalam jangka panjang untuk menangani luka kronis yang diperparah oleh infeksi bakteri telah dilakukan, namun dapat mengakibatkan adanya fenomena antimicrobial resistance, yang dapat mengurangi efektivitas antibiotik terhadap infeksi bakteri, menunjukkan perlunya pengobatan alternatif yang lebih efektif dan efisien. Komposit nanofiber polyacrylonitrile (PAN)/Cu2O Quantum Dots (QDs) menjadi strategi yang efektif karena dapat memproduksi reactive oxygen species (ROS) dan memiliki kemiripan dengan lingkungan extracelullar matrix (ECM) dengan morfologi diameter seratnya. Penelitian ini dilakukan dengan tujuan memahami karakteristik serat komposit nanofiber PAN/Cu2O dan hubungannya dengan performa wound healing. Cu2O QDs disintesis menggunakan metode wet chemical. Sedangkan nanofiber difabrikasi dengan teknik electrospinning dengan variasi feed rate 0,75 ml/H dan 1 ml/H dan rasio larutan polimer PAN/Cu2O sebesar 9:1, 8:2, dan 7:3. Dari penelitian yang telah dilakukan, didapatkan diameter serat pada variasi 9:1; mL/H, 9:1; 0,75 mL/H, 8:2; 1 mL/H, 8:2; 0,75 mL/H, 7:3; 1 mL/H, 7:3; 0,75 mL/H berturut-turut adalah 3251±188.22 nm, 834.48±163.39 nm, 475.92±31.41 nm, 322.92±21.06 nm, 296.56±17.49 nm, dan 224.16±23.53 nm. Dalam aspek hidrofobisitas setiap sampel memiliki sifat hidrofobik dengan nilai contact angle 136o, 123o, 131o, 146o, 103o, dan 161o. Nilai kekasaran permukaan serat pada sampel 9:1; mL/H dan 7:3; mL/H adalah 130 nm dan 165 nm. Dan yang terakhir, nilai zeta potensial yang mewakili sampel PAN, Cu2O QDs, PAN/Cu2O QDs adalah -4,80 mV, 10,30 mV, -2,90 mV. Berdasarkan rangkaian penelitian yang sudah dilaksanakan, feed rate electrospinning dan rasio polimer berpengaruh terhadap karakteristik serat PAN/Cu2O. Karakteristik serat dengan ukuran diameter lebih kecil, surface roughness lebih tinggi, hidrofobik, dan bermuatan negatif memiliki performa wound healing yang lebih baik ditandai dengan lebih cepatnya penutupan area pada luka. Karakteristik serat ini dimiliki oleh sampel PAN/Cu2O 7:3; 1 mL/H.
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The use of antibiotics in the long term to treat chronic wounds exacerbated by bacterial infections has been carried out, but can result in the phenomenon of antimicrobial resistance, which can reduce the effectiveness of antibiotics against bacterial infections, indicating the need for alternative treatments that are more effective and efficient. Polyacrylonitrile (PAN)/Cu2O Quantum Dots (QDs) nanofiber composites are an effective strategy because they can produce reactive oxygen species (ROS) and have similarities to the extracellular matrix (ECM) environment with the morphology of the fiber diameter. This research was conducted with the aim of understanding the characteristics of PAN/Cu2O nanofiber composite fibers and their relationship with wound healing performance. Cu2O QDs were synthesized using the wet chemical method. Meanwhile, nanofibers were fabricated using electrospinning technique with variations in feed rates of 0.75 ml/H and 1 ml/H and ratios of PAN/Cu2O polymer solutions of 9:1, 8:2 and 7:3. From the research that has been done, the fiber diameter is obtained at the 9:1 variation; mL/H, 9:1; 0.75 mL/H, 8:2; 1 mL/H, 8:2; 0.75 mL/H, 7:3; 1 mL/H, 7:3; 0.75 mL/H were 3251 ±188.22 nm, 834.48 ±163.39 nm, 475.92 ±31.41 nm, 322.92 ±21.06 nm, 296.56 ±17.49 nm, and 224.16 ±23.53 nm. In terms of hydrophobicity, each sample has hydrophobic properties with contact angle values of 136o, 123o, 131o, 146o, 103o and 161o. The fiber surface roughness value in the sample is 9:1; mL/H and 7:3; mL/H are 130 nm and 165 nm. And finally, the zeta potential values representing the PAN, Cu2O QDs, PAN/Cu2O QDs samples are -4.80 mV, 10.30 mV, -2.90 mV. Based on a series of studies that have been carried out, the electrospinning feed rate and polymer ratio affect the characteristics of PAN/Cu2O fibers. The characteristics of fiber with a smaller diameter, higher surface roughness, hydrophobicity, and negative charge have a better wound healing performance as indicated by faster wound closure. The characteristics of this fiber are owned by the PAN/Cu2O 7:3 sample; 1mL/h.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	Serat fiber, Cu2O, penyembuhan luka Nanofiber, wound healing
Subjects:	Q Science > QC Physics > QC173.4.C63 Composite materials Q Science > QH Biology > QH301 Biology T Technology > TP Chemical technology > TP248 Nanogels. Nanoparticles. T Technology > TS Manufactures > TS183 Manufacturing processes. Lean manufacturing.
Divisions:	Faculty of Industrial Technology and Systems Engineering (INDSYS) > Material & Metallurgical Engineering > 28201-(S1) Undergraduate Thesis
Depositing User:	Bintang Panji Perkasa
Date Deposited:	24 Jul 2023 00:46
Last Modified:	24 Jul 2023 00:46
URI:	http://repository.its.ac.id/id/eprint/98973

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