Synthesis of Silica Coated Magnetite Nanoparticles and Identification of Its Properties as a Candidate of Hyperthermia Therapy Materials

Hakeem, Muhammad Ananda Norieman (2023) Synthesis of Silica Coated Magnetite Nanoparticles and Identification of Its Properties as a Candidate of Hyperthermia Therapy Materials. Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Cancer is one of the main causes of death in the world that can occur in both men and women. The treatment that is widely used to cure cancer is chemotherapy, but this method has drawbacks such as toxicity to surrounding healthy cells. Magnetic hyperthermia therapy has become alternative to overcome the disadvantage of chemotherapy. Magnetic hyperthermia is a cancer treatment that uses magnetite (Fe3O4) nanoparticles. Before being applied, Fe3O4 is usually modified on its surface, one of which is coating it with silica. The purpose of this study was to analyze the effect of silica coating on magnetite nanoparticles on the crystal structure and morphology of nanoparticles, characterize the relationship of the material to water, magnetic properties and its potential for use in cancer treatment with hyperthermia therapy. The TEOS concentration used as a source of silica was 1.5, 2, 3 ml. Furthermore, the samples were characterized using XRD, FTIR, SEM, TEM, hydrophobicity, VSM, and testing the effect of magnets on temperature. Fe3O4-SiO2 has been successfully carried out in cubic form. Based on the XRD the presence of surfactant did not significantly affect the crystal structure, but in the FTIR test the addition of surfactant gave rise to new functional groups that appear in the Fe3O4 nanoparticles. The increase addition of surfactants also increases the particle size of the Fe3O4 nanoparticles. The VSM results showed that all samples were superparamagnetic with a saturation value of Fe3O4 of 63.70 emu/g and Fe3O4-SiO2 of 1.5 ml, 2 ml, and 3 ml of 58.25; 56.71; 55.57 emu/g. The results of the hydrophobicity test stated that all samples were hydrophilic. Analysis of the AC magnetic field shows that all samples experience a temperature increase of up to 40-45°C which meets the target for hyperthermia therapy application.
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Kanker merupakan salah satu penyebab utama kematian di dunia yang dapat terjadi baik pada pria maupun wanita. Pengobatan yang banyak digunakan untuk menyembuhkan penyakit kanker adalah kemoterapi, namun cara ini memiliki kelemahan seperti toksisitas terhadap sel-sel sehat di sekitarnya. Terapi hipertermia magnetik telah menjadi alternatif untuk mengatasi kerugian dari kemoterapi. Magnetic hyperthermia adalah pengobatan kanker yang menggunakan nanopartikel magnetite (Fe3O4). Sebelum diaplikasikan, Fe3O4 biasanya dimodifikasi permukaannya, salah satunya dengan melapisinya dengan silika. Tujuan dari penelitian ini adalah menganalisis pengaruh pelapisan silika pada nanopartikel magnetit terhadap struktur kristal dan morfologi nanopartikel, mengkarakterisasi hubungan material dengan air, sifat magnetik dan potensinya untuk digunakan dalam pengobatan kanker dengan terapi hipertermia. Konsentrasi TEOS yang digunakan sebagai sumber silika adalah 1,5, 2, 3 ml. Selanjutnya sampel dikarakterisasi menggunakan XRD, FTIR, SEM, TEM, hidrofobik, VSM, dan pengujian pengaruh magnet terhadap suhu. Fe3O4-SiO2 telah berhasil dilakukan dalam bentuk kubik. Berdasarkan XRD keberadaan surfaktan tidak berpengaruh nyata terhadap struktur kristal, namun pada uji FTIR penambahan surfaktan memunculkan gugus fungsi baru yang muncul pada nanopartikel Fe3O4. Peningkatan penambahan surfaktan juga meningkatkan ukuran partikel nanopartikel Fe3O4. Hasil VSM menunjukkan bahwa semua sampel bersifat superparamagnetik dengan nilai saturasi Fe3O4 sebesar 63,70 emu/g dan Fe3O4-SiO2 sebesar 1,5 ml, 2 ml, dan 3 ml sebesar 58,25; 56,71; 55,57 emu/g. Hasil uji hidrofobisitas menyatakan bahwa semua sampel bersifat hidrofilik. Analisis medan magnet AC menunjukkan bahwa semua sampel mengalami peningkatan suhu hingga 40-45°C yang memenuhi target untuk aplikasi terapi hipertermia.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	Hyperthermia Therapy, Magnetite (Fe3O4), Silica, Magnetit (Fe3O4), Silika, Terapi Hipertermia
Subjects:	R Medicine > RS Pharmacy and materia medica T Technology > TP Chemical technology > TP451.E3 Edible coatings.
Divisions:	Faculty of Industrial Technology and Systems Engineering (INDSYS) > Material & Metallurgical Engineering > 28201-(S1) Undergraduate Thesis
Depositing User:	Muhammad Ananda Norieman Hakeem
Date Deposited:	08 Aug 2023 06:27
Last Modified:	08 Aug 2023 06:27
URI:	http://repository.its.ac.id/id/eprint/99711

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