Pengaruh Rasio Fungsionalisasi Polietilen Glikol Terhadap Karakteristik Nanopartikel Magnetite Bersalut Silika Sebagai Terapi Hipertermia

Kurniawan, Luthfi Fadhil Ramadhan (2023) Pengaruh Rasio Fungsionalisasi Polietilen Glikol Terhadap Karakteristik Nanopartikel Magnetite Bersalut Silika Sebagai Terapi Hipertermia. Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Terapi hipertermia menggunakan panas pada sel kanker pada suhu 41-45°C untuk mengurangi risiko kematian. Ferrofluid yang terbuat dari nanopartikel magnetit superparamagnetik digunakan dalam perawatan ini. Untuk meningkatkan biokompatibilitas dan mengurangi agregasi, pelapisan silika diterapkan pada permukaan nanopartikel magnetit. Fungsionalisasi polietilen glikol (PEG) juga diterapkan untuk meningkatkan biokompatibilitas material. Penelitian ini menganalisis pengaruh pelapisan silika dengan fungsionalisasi PEG pada nanopartikel magnetit (Fe3O4-SiO2-PEG) terhadap struktur kristal, morfologi, ketahanan air, sifat magnetik, dan potensi penggunaannya dalam terapi hipertermia untuk pengobatan kanker. Studi ini menunjukkan potensi fungsionalisasi PEG pada nanopartikel magnetit berlapis silika dalam terapi hipertermia dan potensi aplikasinya dalam pengobatan kanker. Sampel diuji dengan berbagai metode karakterisasi seperti XRD, FTIR, SEM, TEM, hidrofobisitas, VSM, serta pengujian pengaruh magnet terhadap suhu. Lapisan silika dengan TEOS pada nanopartikel magnetit dan fungsionalisasi PEG (Fe3O4-SiO2-PEG) menghasilkan nanopartikel berbentuk kubik. Penambahan surfaktan dan fungsionalisasi tidak mempengaruhi puncak XRD, tetapi pada uji FTIR terbentuk gugus fungsi dari silika dan PEG. Analisis TEM menunjukkan bahwa surfaktan meningkatkan ukuran partikel nanopartikel Fe3O4 secara konsisten. Nanopartikel Fe3O4-SiO2-PEG menunjukkan sifat hidrofilik dengan sudut kontak kurang dari 90°. Nanopartikel Fe3O4-SiO2-PEG menunjukkan sifat superparamagnetik dengan kisaran momen magnetik 52,25-56,62 emu/g. Fe3O4-SiO2-PEG menunjukkan potensi untuk pengobatan kanker pada terapi hipertermia, menerapkan arus AC 8A dan 0,8V selama 15 menit, Fe3O4-SiO2 3ml PEG 1:5 mencapai suhu akhir tertinggi 45°C dengan nilai SAR 65.009 mW/g.
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Hyperthermia therapy uses heat on cancer cells at 41-45°C to reduce the risk of death. Ferrofluid made from superparamagnetic magnetite nanoparticles is used in this treatment. To improve biocompatibility and reduce aggregation, silica coating is applied to the magnetite nanoparticles surface. Polyethylene glycol (PEG) functionalization is also applied to enhance the material's biocompatibility. This study analyzes the effect of silica coating with PEG functionalization on magnetite nanoparticles (Fe3O4-SiO2-PEG) on their crystal structure, morphology, water resistance, magnetic properties, and potential use in hyperthermia therapy for cancer treatment. The study demonstrates the potential of functionalization of PEG on silica coated magnetite nanoparticles in hyperthermia therapy and its potential applications in cancer treatment. The samples were tested using various characterization methods such as XRD, FTIR, SEM, TEM, hydrophobicity, VSM, as well as testing the effect of magnets on temperature. Silica coating with TEOS on magnetite nanoparticles and PEG functionalization (Fe3O4-SiO2-PEG) resulted in cubic-shaped nanoparticles. The addition of surfactant and functionalization did not affect XRD peaks, but in FTIR tests, functional groups from silica and PEG were formed. TEM analysis showed that surfactants increased the particle size of Fe3O4 nanoparticles consistently. Fe3O4-SiO2-PEG nanoparticles showed hydrophilic properties within tha contact angle is less than 90°. Fe3O4-SiO2-PEG nanoparticles demonstrated superparamagnetic properties with a magnetic moment range of 52.25-56.62 emu/g. Fe3O4-SiO2-PEG showed potential for cancer treatment in hyperthermia therapy, applying an AC current of 8A and 0.8V for 15 minutes, Fe3O4-SiO2 3ml PEG 1:5 reached the highest final temperature of 45°C with an SAR value of 65,009 mW/g.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	polietilen glikol, silika, superparmagnetik, terapi hipertermia, hyperthermia therapy, polyethylene glycol, silica, superparamagnetic
Subjects:	R Medicine > RS Pharmacy and materia medica T Technology > TA Engineering (General). Civil engineering (General) > TA418.9.C57 Coatings
Divisions:	Faculty of Industrial Technology and Systems Engineering (INDSYS) > Material & Metallurgical Engineering > 28201-(S1) Undergraduate Thesis
Depositing User:	Luthfi Fadhil Ramadhan Kurniawan
Date Deposited:	29 Jul 2023 04:57
Last Modified:	29 Jul 2023 05:00
URI:	http://repository.its.ac.id/id/eprint/99722

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