Analisis Pengaruh Penambahan Β-Tricalcium Phospate Terhadap Sifat Mekanik Dan Biokompatibilitas Pada Biodegradable Polyurethane Composites Untuk Aplikasi Injectable Bone Cement Scaffold

Amal, Muhammad Ihlasul (2023) Analisis Pengaruh Penambahan Β-Tricalcium Phospate Terhadap Sifat Mekanik Dan Biokompatibilitas Pada Biodegradable Polyurethane Composites Untuk Aplikasi Injectable Bone Cement Scaffold. Other thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Fraktur kompresi tubuh vertebral merupakan kondisi yang sering menyebabkan nyeri punggung yang parah dan dapat menyebabkan dampak yang signifikan terhadap kualitas hidup pasien. Penanganan yang tepat diperlukan untuk mengurangi nyeri, meningkatkan stabilitas fraktur, dan memulihkan fungsi tulang yang terganggu. Salah satu metode yang digunakan adalah vertebroplasti (VP), yaitu prosedur invasif minimal yang melibatkan injeksi semen tulang ke dalam fraktur tubuh vertebral untuk mengurangi rasa sakit dan memperbaiki stabilitas. Penelitian ini bertujuan untuk menganalisis pengaruh komposisi β-tricalcium phosphate (β-TCP) terhadap sifat mekanik, morfologi, biodegradasi, dan biokompatibilitas pada komposit Polyurethane /β-TCP untuk aplikasi sebagai scaffold injectable bone cement. Komposit ini terdiri dari poliuretan (PU) sebagai matriks utama dan β-TCP sebagai pengisi, dengan proporsi variasi β-TCP sebesar 10, 20, 30, dan 40%wt. Metode sintesis menggunakan HDI (Hexamethylene Diisocyanate) sebagai prekursor poliuretan, PCL (Polycaprolacton diol) sebagai pendukung struktural, DMSO sebagai pelarut, BDO (1,4-butanediol) sebagai Chain extender, dan β-TCP dengan air sebagai agen pengembang. Hasil pengujian FTIR menunjukkan bahwa semua variasi komposit menunjukkan adanya pita regangan NH, C=O, pita regangan lengkung C-H, dan getaran regangan C-O, yang mengonfirmasi berhasilnya sintesis PU. Dalam pengujian tekan, nilai rata-rata modulus elastisitas berkisar antara 80,92 hingga 506,4 MPa, dan kekuatan tekan antara 9,24 hingga 45,48 MPa. Uji injectability menunjukkan nilai maximum force antara 8,10 hingga 75,15 N, dan waktu pengerasan komposit PU/β-TCP bervariasi antara 33,33 hingga 54,67 menit. Hasil pengujian weight loss menunjukkan persentase penurunan berat antara 0,79 hingga 7,41%. Meskipun beberapa sampel menunjukkan tingkat sedikit beracun, hasil pengujian MTT assay secara keseluruhan memberikan gambaran positif. Berdasarkan hasil pengujian tersebut, sampel uji PU/β-TCP dengan konsentrasi β-TCP 40%wt tanpa penambahan DMSO dianggap sebagai pilihan terbaik sebagai injectable bone cement scaffold.
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Vertebral body compression fracture is a condition that often causes severe back pain and can have a significant impact on the patient's quality of life. Appropriate treatment is needed to reduce pain, increase fracture stability, and restore impaired bone function. One method used is vertebroplasty (VP), which is a minimally invasive procedure that involves the injection of bone cement into the fractured vertebral bodies to reduce pain and improve stability. This study aims to analyze the effect of the composition of β-tricalcium phosphate (β-TCP) on the mechanical properties, morphology, biodegradation, and biocompatibility of Polyurethane /β-TCP composites for application as scaffold injectable bone cement. This composite consisted of Polyurethane (PU) as the main matrix and β-TCP as filler, with varying proportions of β-TCP of 10, 20, 30, and 40% wt. The synthesis method uses HDI (Hexamethylene Diisocyanate) as a Polyurethane precursor, PCL (Polycaprolacton diol) as a structural support, DMSO as a solvent, BDO (1,4-butanediol) as a chain extender, and β-TCP with water as a swelling agent. The FTIR test results showed that all variations of the composites showed the presence of NH, C=O strain bands, C-H curved strain bands, and C-O strain vibrations, which confirmed the successful synthesis of PU. In the compression test, the average values of the modulus of elasticity ranged from 80.92 to 506.4 MPa, and the compressive strength was from 9.24 to 45.48 MPa. The injectability test showed the maximum force values were between 8.10 and 75.15 N, and the hardening time of the PU/β-TCP composite varied between 33.33 and 54.67 minutes. The results of the weight loss test showed that the percentage of weight loss was between 0.79 and 7.41%. Although some samples showed slightly toxic levels, the overall results of the MTT assay were positive. Based on the test results, the PU/β-TCP test sample with 40%wt β-TCP concentration without the addition of DMSO was considered the best choice as an injectable bone cement scaffold.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	β-Tricalcium phosphate, Bone Cement, Injectable, Polyurethane , Verteboplasty,β-Tricalcium phosphate, Bone Cement, Injectable, Polyurethane , Verteboplasty
Subjects:	Q Science > QP Physiology > QP801.P64 Polymers--Biodegradation
Divisions:	Faculty of Industrial Technology and Systems Engineering (INDSYS) > Material & Metallurgical Engineering > 28201-(S1) Undergraduate Thesis
Depositing User:	Muhammad Ihlasul Amal
Date Deposited:	27 Jul 2023 04:10
Last Modified:	27 Jul 2023 04:10
URI:	http://repository.its.ac.id/id/eprint/99784

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