Pengaruh kadar H.O terlalu dalam karbon dioksida superkritis terhadap pembentukan kompleks inklusi ketoprofen-B- cyclodentrin

Goenawan, Joshua (2015) Pengaruh kadar H.O terlalu dalam karbon dioksida superkritis terhadap pembentukan kompleks inklusi ketoprofen-B- cyclodentrin. Undergraduate thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Obat yang dikonsumsi secaral oral banyak digunakan untuk menyembuhkan berbagai jenis penyakit dikarenakan kemudahan dalam mengkonsumsinya, fleksibilitas desain obat sesuai dosis yang digunakan, dan resiko kemandulan yang rendah. Ketoprofen merupakan salah satu jenis obat yang dikonsumsi secara oral. Ketoprofen termasuk dalam golongan Non Steroidal Anti- Inflammatory Drug (NSAID) yang memiliki kelarutan rendah dalam air. Laju disolusi dapat ditingkatkan dengan pembentukan kompleks inklusi ketoprofen dalam β-cyclodextrin menggunakan karbon dioksida superkritis yang mengandung H2O terlarut. Tujuan dari penelitian ini adalah mempelajari pengaruh kadar H2O terlarut dalam karbon dioksida superkritis terhadap persentase kompleks inklusi ketoprofen - β-cyclodextrin yang terbentuk dan karakteristik kinerja obat. Penelitian ini diawali dengan membuat campuran ketoprofen - β-cyclodextrin dengan perbandingan berat 1:5 kemudian campuran disaturasi dengan karbon dioksida superkritis yang mengandung H2O terlarut pada berbagai suhu penjenuhan (30-50 oC) dan tekanan penjenuhan 130 bar serta suhu inklusi 50 oC pada berbagai tekanan inklusi (150-200 bar) . Saturasi dilakukan selama ± 2 jam disertai dengan pengadukan. Beberapa metode analisis seperti Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), Drug Release dan Drug Loading akan digunakan untuk mempelajari karakter dari kompleks inklusi. Persentase kompleks inklusi yang dihasilkan sebesar 90,45% - 100%. Hasil uji drug release menghasilkan persentase ketoprofen terlarut sebesar 79,85%-99,98% pada berbagai kadar air terlarut dalam CO2 superkritis dan berbagai tekanan inklusi. ====================================================================================================== Oral ingestion drugs are widely used to cure various types of disease due to its ease of consuming the drug, flexibility in the design of dosage form, and least sterility constraints. Ketoprofen is one type of drug that is taken orally. Ketoprofen is a Non Steroidal Anti-Inflammatory Drug (NSAID) which has low solubility in water. The dissolution rate can be increased by making inclusion complex of ketoprofen in β-cyclodextrin with supercritical fluid (SCF) technology. The goals of this research are to study the influence of H2O concentration in the supercritical carbondioxide to the percentage of ketoprofen - β- cyclodextrin inclusion complex and the performance characteristic of the drug. This research begins with making a mixture of ketoprofen - β-cyclodextrin by manually mixing them with the weight ratio 1:5 then it is saturated by supercritical carbondioxide at various saturation temperatures (30-50 oC) and the saturation pressure of 130 bar with the temperature of inclusion at 50 oC on various inclusion pressures (150-200 bar) for about 2 hours and mixed continuously. The materials were charactarized by Differential Scanning Calorimetry (DSC), drug loading, and drug release techniques. The percentage of the inclusion complexes are 90,45% - 100%. The percentage recovery of ketoprofen are 71,59%-99,43% and the percentage drug released of ketoprofen are 79,85%-99,98% on various water content in supercritical CO2 and various inclusion pressures.

Item Type: Thesis (Undergraduate)
Additional Information: RSK 660.63 Goe p
Uncontrolled Keywords: ketoprofen, cyclodextrin, kompleks inklusi, karbon dioksida, superkritis, air ================================================================================================ ketoprofen, cyclodextrin, inclusion complex, carbon dioxide, supercritical fluid (SCF), water
Subjects: Q Science > QD Chemistry > QD75.2 Chemistry, Analytic
Divisions: Faculty of Industrial Technology > Chemical Engineering > 24201-(S1) Undergraduate Thesis
Depositing User: - Taufiq Rahmanu
Date Deposited: 02 Apr 2019 03:34
Last Modified: 02 Apr 2019 03:34
URI: https://repository.its.ac.id/id/eprint/62683

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