Isolasi Senyawa Terpenoid Daun Chromolaena odorata L.

Risnah, Indah Ayu (2021) Isolasi Senyawa Terpenoid Daun Chromolaena odorata L. Masters thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Chromolaena odorata L. termasuk ke dalam salah satu famili Asteraceae yang telah digunakan secara tradisional sebagai obat diabetes di beberapa negara, seperti India, Nigeria, Thailand, serta Indonesia (Maluku dan Aceh). Penelitian ini bertujuan untuk mengisolasi dan menentukan struktur senyawa metabolit sekunder fraksi diklorometana daun C. odorata Selanjutnya, pada fraksi diklorometana daun C. odorata telah berhasil diisolasi senyawa terpenoid yaitu S1, (6E,10E)-2,6,10-trimetilpentadeka-2,6,10-triena (160 mg), dan S2 (75 mg) yang terdiri dari campuran lupeol, α-amyrin dan β-amyrin. Penentuan struktur S1 dan S2 berdasarkan data NMR (1H dan 13C-NMR, HMQC dan HMBC) serta perbandingan dengan literatur. ===================================================================================================== Chromolaena odorata belongs to the Asteraceae family, which has been used traditionally as a diabetes medicine in several countries, such as India, Nigeria, Thailand, and Indonesia (Maluku and Aceh). This study aims to isolate and determine the structure of secondary metabolites of dichloromethane fraction from C. odorata leaves. Furthermore, in the dichloromethane fraction of C. odorata leaves, terpenoid compounds, S1, (6E,10E)-2,6,10-trimetilpentadeka-2,6,10-triena (160 mg), and S2 (75 mg) is a mixture compound of lupeol, α-amyrin and β-amyrin, had been isolated. Structure elucidation based on spectroscopic NMR (1H and 13C-NMR, HMQC and HMBC) and comparison with literatures.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Chromolaena odorata, metabolit sekunder, obat traditional, terpenoid, Chromolaena odorata, secondary metabolites, traditional medicine, terpenoid.
Subjects: Q Science > QD Chemistry
Q Science > QD Chemistry > QD251.2 Chemistry, Organic. Biochemistry
Divisions: Faculty of Science and Data Analytics (SCIENTICS) > Chemistry > 47101-(S2) Master Thesis
Depositing User: Indah Ayu Risnah
Date Deposited: 28 Jun 2021 08:33
Last Modified: 28 Jun 2021 08:33
URI: https://repository.its.ac.id/id/eprint/84254

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