Faqih, Mu'adz Abdullah (2021) Analisis Pengaruh Silane Coupling Agent Dan Rasio Porogen Terhadap Morfologi, Sifat Mekanik, Dan Biodegradasi 3d Scaffolds Komposit PCL/Nano-Hidroksiapatit. Undergraduate thesis, Institut Teknologi Sepuluh Nopember.
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Abstract
Kasus fraktur tulang di Indonesia setiap tahun meningkat, yang mana berbanding lurus dengan jumlah kecelakaan yang terjadi. 3D scaffolds adalah komponen yang banyak digunakan untuk membantu penyembuhan fraktur tulang. Polimer poly(caprolactone) (PCL) dan keramik hidroksiapatit (HAp) adalah bahan yang dapat digunakan sebagai 3D scaffolds, karena memiliki sifat biokampatibel, osteokonduktif, terdegradasi dalam tubuh, dan tidak beracun. Penelitian ini bertujuan untuk menganalisis pengaruh penambahan silane coupling agent 3-aminopropyl triethoxy silane (APTES) dan pengaruh rasio porogen (NaCl) pada komposit (PCL/nHAp) terhadap morfologi, sifat mekanik, dan biodegradasi 3D scaffolds. Metode yang digunakan untuk fabrikasi yaitu Solvent Casting Particulate Leaching (SCPL) dengan variasi APTES sebesar 1, 3, dan 5% terhadap nHAp dan rasio porogen NaCl sebesar 4:1, 6:1, dan 8:1 terhadap komposit. Dari penelitian ini ditemukan bahwa penambahan 1% APTES dapat meningkatkan kekuatan tarik dan tekan mencapai 0,31 dan 0,87 MPa serta lifetime 380 hari. Sedangkan kenaikan rasio porogen hingga 8:1 meningkatkan porositas sebesar 78.16%, serta menurunkan kekuatan tarik dan tekan mencapai 0.04 dan 0.14 MPa dan lifetime hingga 134 hari.
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The number cases of bone fractures in Indonesia are increases in each year, which is directly proportional to the number of accidents. 3D scaffolds are a type of component that is commonly utilized to aid in the healing of bone fractures. Because they are biocompatible, osteoconductive, biodegradable, and non-toxic, poly(caprolactone) (PCL) polymer and hydroxyapatite ceramic (HAp) can be employed as 3D scaffolds. The goal of this research is to analysis effect of adding a silane coupling agent, 3-aminopropyl triethoxy silane (APTES), as well as the porogen ratio (NaCl) in composites (PCL/nHAp), affects the shape, mechanical characteristics, and biodegradation of 3D scaffolds. Solvent Casting Particulate Leaching (SCPL) was employed for the fabrication, with APTES variations of 1, 3, and 5% for nHAp and porogen NaCl ratios of 4:1, 6:1, and 8:1 for composites. The results of this study showed that The addition of 1% APTES can increase tensile and compressive strength to 0.31 and 0.87 MPa, respectively, with a 380-day lifetime. In the meantime, increasing the porogen ratio to 8:1 increases porosity by 78.1 percent, lowers tensile and compressive strength to 0.04 and 0.14 MPa, and extends the lifetime to 134 days.
| Item Type: | Thesis (Undergraduate) |
|---|---|
| Uncontrolled Keywords: | 3D Scaffolds, Nano-Hydroxyapatite, PCL, Silane coupling agent, Solvent Casting/Particulate Leaching |
| Subjects: | Q Science > QC Physics > QC173.4.C63 Composite materials T Technology > T Technology (General) > TA404 Materials--Biodegradation |
| Divisions: | Faculty of Industrial Technology and Systems Engineering (INDSYS) > Material & Metallurgical Engineering > 28201-(S1) Undergraduate Thesis |
| Depositing User: | Mu'adz Abdullah Faqih |
| Date Deposited: | 15 Aug 2021 18:28 |
| Last Modified: | 15 Aug 2021 18:28 |
| URI: | http://repository.its.ac.id/id/eprint/86871 |
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