Sintesis Cangkang Kapsul Keras Dari Kitosan Larut Air Dengan Penambahan Karagenan Dan Pati Ubi Jalar Putih

Tiany, Herlina Krise (2021) Sintesis Cangkang Kapsul Keras Dari Kitosan Larut Air Dengan Penambahan Karagenan Dan Pati Ubi Jalar Putih. Masters thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Cangkang kapsul keras telah berhasil disintesis dari kitosan larut air (WSC), karagenan dan pati ubi jalar putih. WSC disintesis dari kitosan kepiting melalui reaksi depolimerisasi. WSC yang digunakan adalah 1,2,3,4,5 gram sedangkan karagenan dan pati yang digunakan adalah 1,5 gram dan 1 gram. Berdasarkan spektrum FTIR, menunjukkan bahwa cangkang kapsul yang diperoleh memiliki vibrasi dari molekul penyusunnya yaitu kitosan, karagenan dan pati. Berdasarkan uji keseragaman, uji degradasi, cangkang kapsul yang dihasilkan memenuhi syarat Farmakope Indoensia. Berdasarkan Uji SEM, cangkang kapsul dengan variasi 3:1,5:1 (WSC: Karagenan:Pati) memiliki pori kecil pada permukaannya. Berdasarkan seluruh data penelitian diperoleh, bahwa kapsul dengan Variasi 3:1,5:1 (WSC:Karagenan) yang paling sesuai dengan kapsul komersial. ===================================================================================================== Hard capsule have been successfully synthesized from water soluble chitosan (WSC), carrageenan and white sweet potato starch. WSC was synthesized from crab chitosan through depolymerization reaction. WSC used was 1,2,3,4,5 gram while carrageenan and starch used were 1,5 gram and 1 gram. Based on the FTIR spectrum, it shows that the hard capsule obtained has vibrations from its constituent molecules, ie chitosan, carrageenan and starch. Based on the uniformity test and degradation test all capsules produced appropriate with Farmakope Indonesia. Based on the SEM test, the capsule with a variation of 3:1,5:1 (WSC:Carrageenan:Starch) has small pores on its surface. Based on all the data studied, capsules with Variation 3:1.5:1 (WSC:Carageenan:Starch) were the most appropriate for commercial capsules.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Kata Kunci:Cangkang kapsul, kitosan larut air (WSC), karagenan, pati ubi jalar putih Key word: Capsule shells, water soluble chitosan (WSC), carageenan, starch white sweet potato.
Subjects: Q Science > QD Chemistry > QD75.2 Chemistry, Analytic
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Science and Data Analytics (SCIENTICS) > Chemistry > 47101-(S2) Master Thesis
Depositing User: Herlina Krise Tiany
Date Deposited: 24 Aug 2021 13:46
Last Modified: 24 Aug 2021 13:46
URI: https://repository.its.ac.id/id/eprint/89521

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